Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2994 |
Resumo: | Introduction: Until recently, surgical correction of gingival recession (GR) was the elective treatment; but it requires tissue donation, and it is limited to small areas. There was a growing interest in blood elements with regenerative potential after the development of non-absorbable membranes for blood clot stabilization and cell dif-ferentiation around exposed roots. This study aimed to carry out an integrative re-view on the treatment of GR. Methods: We used descriptive and qualitative analysis methodologies of the available bibliography on the subject. Results: We found that several studies examined the application of plasma concentrates, obtained by dif-ferent protocols or angles of centrifugation, such as platelet rich fibrin (PRF) and its advanced (A-PRF) and injectable forms (I-PRF) associated with periodontal surger-ies to increase the keratinized tissue and the root covering. The isolated I-PRF was also applied to individuals with thin gingiva, not associated with complex surgeries of root covering by coronal flap, but these protocols included microneedling, to stim-ulate collagen production. After 6 months, individuals submitted to microneedling and injection of I-PRF and those treated only with I-PRF have similar gingival thick-ness, showing that the two procedures were equally effective. These results led to the search for a better understanding of the composition of the I-PRF, as a cell ma-trix with cytokines and platelet aggregates effector of tissue repair and regenerate gingiva. Additionally, these results highlighted the need to change the centrifuga-tion procedure to obtain different cell strains, and to conduct new studies to compare gingival growth, using these different centrifuge pattern with changes in the speed and time. Conclusion: Current results show the potential use of I-PRF to repair peri-odontium and gingival tissue. Advancements in the techniques of cell selection and cytokines, and better identification of pathological processes linked to PRF, will be aimed at prevention and early approach of RG, limiting its evolution and need for surgical and complex corrective procedures. |
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Queiroz, Márcia Silvahttp://lattes.cnpq.br/1927869803694015Queiroz, Márcia Silvahttp://lattes.cnpq.br/1927869803694015Horliana, Anna Carolina Ratto Tempestinihttp://lattes.cnpq.br/0442315483134442Monteiro, Douglas Robertohttp://lattes.cnpq.br/2795875575479712http://lattes.cnpq.br/0455711830847296Santos, Roberto Felipe dos2022-07-21T18:17:58Z2020-12-17Santos, Roberto Felipe dos. Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura. 2020. 41 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2994Introduction: Until recently, surgical correction of gingival recession (GR) was the elective treatment; but it requires tissue donation, and it is limited to small areas. There was a growing interest in blood elements with regenerative potential after the development of non-absorbable membranes for blood clot stabilization and cell dif-ferentiation around exposed roots. This study aimed to carry out an integrative re-view on the treatment of GR. Methods: We used descriptive and qualitative analysis methodologies of the available bibliography on the subject. Results: We found that several studies examined the application of plasma concentrates, obtained by dif-ferent protocols or angles of centrifugation, such as platelet rich fibrin (PRF) and its advanced (A-PRF) and injectable forms (I-PRF) associated with periodontal surger-ies to increase the keratinized tissue and the root covering. The isolated I-PRF was also applied to individuals with thin gingiva, not associated with complex surgeries of root covering by coronal flap, but these protocols included microneedling, to stim-ulate collagen production. After 6 months, individuals submitted to microneedling and injection of I-PRF and those treated only with I-PRF have similar gingival thick-ness, showing that the two procedures were equally effective. These results led to the search for a better understanding of the composition of the I-PRF, as a cell ma-trix with cytokines and platelet aggregates effector of tissue repair and regenerate gingiva. Additionally, these results highlighted the need to change the centrifuga-tion procedure to obtain different cell strains, and to conduct new studies to compare gingival growth, using these different centrifuge pattern with changes in the speed and time. Conclusion: Current results show the potential use of I-PRF to repair peri-odontium and gingival tissue. Advancements in the techniques of cell selection and cytokines, and better identification of pathological processes linked to PRF, will be aimed at prevention and early approach of RG, limiting its evolution and need for surgical and complex corrective procedures.Introdução: A correção cirúrgica tem sido o tratamento preconizado para recessão gengival (RG), apesar das diversas limitações como necessidade de local de doação de tecido, recobrimento de áreas pequenas, execução demorada e custo elevado. Com o desenvolvimento de membranas não-absorvíveis para estabilização do coágulo sanguíneo e diferenciação celular ao redor das raízes expostas, houve um crescente interesse por elementos sanguíneos com potencial regenerativo.O objetivo deste trabalho foi realizar uma revisão integrativa sobre o tratamento de RG. Métodos: Realizados uma revisão descritiva, qualitativa da bibliografia disponível sobre o assunto. Resultados: Diversos estudos examinaram a aplicação de concentrados plasmáticos, obtidos por diferentes protocolos ou ângulos de centrifugação, como o Fibrina Rica em Plaquetas (PRF) e suas formas avançada (A-PRF) e injetável (I-PRF), em complementação às cirurgias periodontais no aumento do tecido queratinizado e o recobrimento radicular. Posteriormente, o I-PRF isolado foi aplicado associado à técnica de microagulhamento, para estimular a produção de colágeno. Após 6 meses, o ganho de espessura gengival foi semelhante entre os indivíduos submetidos ao microagulhamento e injeção de I-PRF e naqueles tratados apenas com I-PRF, mostrando efetividade dos dois procedimentos. Estes resultados levaram à busca de melhor entendimento sobre a composição do I-PRF, como matriz de células, citocinas e agregados plaquetários efetores de reparo e regeneração tecidual. Também evidenciaram a necessidade de modificações na forma de centrifugar o sangue, no sentido de obter diferentes componentes e linhagens celulares, tornando indispensáveis novos estudos comparativos de crescimento gengival com a adoção de novos protocolos de centrifugação. Conclusão: Os resultados atuais apontam para o potencial uso do I-PRF na reparação do periodonto e tecido gengival. Com o avanço nas técnicas de seleção celular e de citocinas, indispensáveis para a estimulação e reparo, e a identificação de processos patológicos ligados à RG, o tratamento será voltado para prevenção e abordagem precoce, impedindo sua evolução e necessidade de procedimentos corretivos cirúrgicos e complexos.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2022-07-21T18:17:58Z No. of bitstreams: 1 Roberto Felipe dos Santos.pdf: 1004070 bytes, checksum: fb75b81ba32ba52899481f4cb682103e (MD5)Made available in DSpace on 2022-07-21T18:17:58Z (GMT). No. of bitstreams: 1 Roberto Felipe dos Santos.pdf: 1004070 bytes, checksum: fb75b81ba32ba52899481f4cb682103e (MD5) Previous issue date: 2020-12-17application/pdfporUniversidade Nove de JulhoPrograma de Mestrado em MedicinaUNINOVEBrasilSaúdefibrina rica em plaquetasrecessão gengival/terapia.platelet-rich fibringingival recession/therapyCIENCIAS DA SAUDEFibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literaturainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALRoberto Felipe dos Santos.pdfRoberto Felipe dos Santos.pdfapplication/pdf1004070http://localhost:8080/tede/bitstream/tede/2994/2/Roberto+Felipe+dos+Santos.pdffb75b81ba32ba52899481f4cb682103eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2994/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/29942022-07-21 15:17:58.795oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2022-07-21T18:17:58Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura |
title |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura |
spellingShingle |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura Santos, Roberto Felipe dos fibrina rica em plaquetas recessão gengival/terapia. platelet-rich fibrin gingival recession/therapy CIENCIAS DA SAUDE |
title_short |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura |
title_full |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura |
title_fullStr |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura |
title_full_unstemmed |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura |
title_sort |
Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura |
author |
Santos, Roberto Felipe dos |
author_facet |
Santos, Roberto Felipe dos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Queiroz, Márcia Silva |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1927869803694015 |
dc.contributor.referee1.fl_str_mv |
Queiroz, Márcia Silva |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/1927869803694015 |
dc.contributor.referee2.fl_str_mv |
Horliana, Anna Carolina Ratto Tempestini |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/0442315483134442 |
dc.contributor.referee3.fl_str_mv |
Monteiro, Douglas Roberto |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/2795875575479712 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0455711830847296 |
dc.contributor.author.fl_str_mv |
Santos, Roberto Felipe dos |
contributor_str_mv |
Queiroz, Márcia Silva Queiroz, Márcia Silva Horliana, Anna Carolina Ratto Tempestini Monteiro, Douglas Roberto |
dc.subject.por.fl_str_mv |
fibrina rica em plaquetas recessão gengival/terapia. |
topic |
fibrina rica em plaquetas recessão gengival/terapia. platelet-rich fibrin gingival recession/therapy CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
platelet-rich fibrin gingival recession/therapy |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: Until recently, surgical correction of gingival recession (GR) was the elective treatment; but it requires tissue donation, and it is limited to small areas. There was a growing interest in blood elements with regenerative potential after the development of non-absorbable membranes for blood clot stabilization and cell dif-ferentiation around exposed roots. This study aimed to carry out an integrative re-view on the treatment of GR. Methods: We used descriptive and qualitative analysis methodologies of the available bibliography on the subject. Results: We found that several studies examined the application of plasma concentrates, obtained by dif-ferent protocols or angles of centrifugation, such as platelet rich fibrin (PRF) and its advanced (A-PRF) and injectable forms (I-PRF) associated with periodontal surger-ies to increase the keratinized tissue and the root covering. The isolated I-PRF was also applied to individuals with thin gingiva, not associated with complex surgeries of root covering by coronal flap, but these protocols included microneedling, to stim-ulate collagen production. After 6 months, individuals submitted to microneedling and injection of I-PRF and those treated only with I-PRF have similar gingival thick-ness, showing that the two procedures were equally effective. These results led to the search for a better understanding of the composition of the I-PRF, as a cell ma-trix with cytokines and platelet aggregates effector of tissue repair and regenerate gingiva. Additionally, these results highlighted the need to change the centrifuga-tion procedure to obtain different cell strains, and to conduct new studies to compare gingival growth, using these different centrifuge pattern with changes in the speed and time. Conclusion: Current results show the potential use of I-PRF to repair peri-odontium and gingival tissue. Advancements in the techniques of cell selection and cytokines, and better identification of pathological processes linked to PRF, will be aimed at prevention and early approach of RG, limiting its evolution and need for surgical and complex corrective procedures. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-12-17 |
dc.date.accessioned.fl_str_mv |
2022-07-21T18:17:58Z |
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dc.identifier.citation.fl_str_mv |
Santos, Roberto Felipe dos. Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura. 2020. 41 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2994 |
identifier_str_mv |
Santos, Roberto Felipe dos. Fibrina rica em plaquetas e a aplicabilidade de sua forma injetável no reparo tecidual de recessão gengival de biotipo delgado: revisão integrativa da literatura. 2020. 41 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
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