Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1344 |
Resumo: | The acute respiratory distress syndrome (ARDS) is a disease characterized by respiratory failure due to an inflammatory response, which has high morbidity and mortality. Several cytokines seem to orchestrate the acute and chronic processes, mainly mediated by toll like receptors (TLRs). The literature demonstrates that aerobic exercise (AE) is capable of decreasing the secretion of pro-inflammatory cytokines in the lungs mediated increased release of interleukin 10 (IL-10), and AE modulate expression of TLRs and antioxidant enzymes. The objective of this study was to evaluate whether the anti-inflammatory effects of AE in an experimental model of intra and extrapulmonary ARDS are mediated by IL-10. For this, the animals were subjected to physical training on a treadmill, moderate for 4 weeks. 24 hours after the last physical test, animals received LPS by intratracheally (it) (10ug / animal) or intraperitoneally (ip) (100ug / animal). After 24 hours, the animals were assessed for the number of cells and pro- and anti-inflammatory cytokines in bronchoalveolar lavage fluid (BAL) and serum were the number of neutrophils in the lung parenchyma and expression of TLR4, TLR7, SOD, ??nion and QL in lung homogenates. AE reduced accumulation of neutrophils in the lung parenchyma, so it LPS and LPS ip (p <0.01) and BAL (p <0.01). AE attenuate the levels of proinflammatory cytokines in BAL and serum (p <0.05), as measured by ELISA. AE had levels of anti-inflammatory cytokine IL-10 increased in the serum and BAL (p <0.05). AE also reduced the expression of TLR4 in lung homogenates (p <0.05) and increased the expression of TLR7 in group LPS + AE evaluated by western blotting (p <0.05). The results for the antioxidant enzyme SOD showed a significant increase in the groups submitted to AE. It follows that the impact of reduced LPS-induced ARDS, regardless of etiology, and these effects appear to be mediated by modulation of the AE secretion of anti-inflammatory cytokines, especially IL-10, modulating TLR4 and TLR7 and increased expression of SOD (p <0.05). |
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Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/9213556008468472Carvalho, Regiane Albertini dehttp://lattes.cnpq.br/2515657728339113Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/9213556008468472Romanholo, Beatriz Mangueira Saraivahttp://lattes.cnpq.br/6037246361594215Oliveira, Lu??s Vicente Franco dehttp://lattes.cnpq.br/3644494034569111http://lattes.cnpq.br/6492329271471517Oliveira, Nicole Cristine Rigonato de2016-05-25T16:04:47Z2014-12-19Oliveira, Nicole Cristine Rigonato de. Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental. 2014. 81 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho,S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1344The acute respiratory distress syndrome (ARDS) is a disease characterized by respiratory failure due to an inflammatory response, which has high morbidity and mortality. Several cytokines seem to orchestrate the acute and chronic processes, mainly mediated by toll like receptors (TLRs). The literature demonstrates that aerobic exercise (AE) is capable of decreasing the secretion of pro-inflammatory cytokines in the lungs mediated increased release of interleukin 10 (IL-10), and AE modulate expression of TLRs and antioxidant enzymes. The objective of this study was to evaluate whether the anti-inflammatory effects of AE in an experimental model of intra and extrapulmonary ARDS are mediated by IL-10. For this, the animals were subjected to physical training on a treadmill, moderate for 4 weeks. 24 hours after the last physical test, animals received LPS by intratracheally (it) (10ug / animal) or intraperitoneally (ip) (100ug / animal). After 24 hours, the animals were assessed for the number of cells and pro- and anti-inflammatory cytokines in bronchoalveolar lavage fluid (BAL) and serum were the number of neutrophils in the lung parenchyma and expression of TLR4, TLR7, SOD, ??nion and QL in lung homogenates. AE reduced accumulation of neutrophils in the lung parenchyma, so it LPS and LPS ip (p <0.01) and BAL (p <0.01). AE attenuate the levels of proinflammatory cytokines in BAL and serum (p <0.05), as measured by ELISA. AE had levels of anti-inflammatory cytokine IL-10 increased in the serum and BAL (p <0.05). AE also reduced the expression of TLR4 in lung homogenates (p <0.05) and increased the expression of TLR7 in group LPS + AE evaluated by western blotting (p <0.05). The results for the antioxidant enzyme SOD showed a significant increase in the groups submitted to AE. It follows that the impact of reduced LPS-induced ARDS, regardless of etiology, and these effects appear to be mediated by modulation of the AE secretion of anti-inflammatory cytokines, especially IL-10, modulating TLR4 and TLR7 and increased expression of SOD (p <0.05).A s??ndrome do desconforto respirat??rio agudo (SDRA) ?? uma doen??a caracterizada pela insufici??ncia respirat??ria decorrente a uma resposta inflamat??ria, que apresenta alta morbi-mortalidade. Diversas citocinas parecem orquestrar os processos agudo e cr??nico, mediados principalmente por receptores toll like (TLRs). A literatura demonstra que o exerc??cio aer??bio (EA) ?? capaz de diminuir a secre????o de citocinas pr??-inflamat??rias nos pulm??es, mediado pelo aumento da libera????o de interleucina 10 (IL-10), al??m de o EA modular a express??o de TLRs e enzimas antioxidantes. Assim, o objetivo desse estudo foi avaliar se os efeitos anti-inflamat??rios do EA em modelo experimental da SDRA intra e extrapulmonar s??o mediados por IL-10. Para isso, os animais foram submetidos ao treinamento f??sico em esteira, de intensidade moderada, durante 4 semanas. Ap??s 24 horas ao ??ltimo teste f??sico, os animais receberam LPS por via intra-traqueal (it) (10ug/animal) ou por via intra-peritoneal (ip) (100ug/animal). Ap??s 24 horas, os animais foram avaliados para o n??mero de c??lulas e de citocinas pr?? e anti-inflamat??rias no flu??do do lavado broncoalveolar (LBA) e no soro, n??mero de neutr??filos no par??nquima pulmonar e express??o do TLR4, TLR7, SOD, ??nion e QL nos homogenatos de pulm??o. EA reduziu a acumula????o de neutr??filos no par??nquima pulmonar, tanto LPS it e LPS ip (p <0,01) e no LBA (p <0,01). EA atenuou os n??veis de citocinas pr??-inflamat??rias no LBA e soro (p <0,05), avaliada por ELISA. EA teve os n??veis da citocina anti-inflamat??ria IL-10 aumentados no soro e LBA (p <0,05). EA tamb??m reduziu a express??o de TLR4 nos homogenatos de pulm??o (p <0,05) e aumentou a express??o de TLR7 no grupo de LPS + EA avaliada por western blotting (p <0,05). Os resultados para a enzima antioxidante SOD apresentou aumento significante nos grupos submetidos ao EA. Conclui-se que EA reduziu o impacto de SDRA induzida por LPS, independente da etiologia e tais efeitos parecem estar mediados pela modula????o do EA na secre????o de citocinas anti-inflamat??rias, principalmente da IL-10, na modula????o de TLR4 e TLR7 e no aumento da express??o de SOD (p<0,05).Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-25T16:04:47Z No. of bitstreams: 1 Nicole Cristine Rigonato de Oliveira.pdf: 1240943 bytes, checksum: 14fa67b6692555f3bc76fb1f34186220 (MD5)Made available in DSpace on 2016-05-25T16:04:47Z (GMT). No. of bitstreams: 1 Nicole Cristine Rigonato de Oliveira.pdf: 1240943 bytes, checksum: 14fa67b6692555f3bc76fb1f34186220 (MD5) Previous issue date: 2014-12-19application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??deexerc??cio aer??bios??ndrome do desconforto respirat??rio agudointerleucina-10receptor toll like 4receptor toll like 7SODaerobic exerciseacute respiratory distress syndromeinterleukin-10toll like receptor 4toll like receptor 7SODCIENCIAS DA SAUDEAvalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimentalEvaluation of the role of interleukin-10 in anti inflammatory effects of aerobic exercise on experimental acute respiratory distress syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALNicole Cristine Rigonato de Oliveira.pdfNicole Cristine Rigonato de Oliveira.pdfapplication/pdf1240943http://localhost:8080/tede/bitstream/tede/1344/2/Nicole+Cristine+Rigonato+de+Oliveira.pdf14fa67b6692555f3bc76fb1f34186220MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1344/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/13442016-05-25 13:04:47.062oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2016-05-25T16:04:47Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental |
dc.title.alternative.eng.fl_str_mv |
Evaluation of the role of interleukin-10 in anti inflammatory effects of aerobic exercise on experimental acute respiratory distress syndrome |
title |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental |
spellingShingle |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental Oliveira, Nicole Cristine Rigonato de exerc??cio aer??bio s??ndrome do desconforto respirat??rio agudo interleucina-10 receptor toll like 4 receptor toll like 7 SOD aerobic exercise acute respiratory distress syndrome interleukin-10 toll like receptor 4 toll like receptor 7 SOD CIENCIAS DA SAUDE |
title_short |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental |
title_full |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental |
title_fullStr |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental |
title_full_unstemmed |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental |
title_sort |
Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental |
author |
Oliveira, Nicole Cristine Rigonato de |
author_facet |
Oliveira, Nicole Cristine Rigonato de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9213556008468472 |
dc.contributor.advisor-co1.fl_str_mv |
Carvalho, Regiane Albertini de |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/2515657728339113 |
dc.contributor.referee1.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9213556008468472 |
dc.contributor.referee2.fl_str_mv |
Romanholo, Beatriz Mangueira Saraiva |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/6037246361594215 |
dc.contributor.referee3.fl_str_mv |
Oliveira, Lu??s Vicente Franco de |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/3644494034569111 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6492329271471517 |
dc.contributor.author.fl_str_mv |
Oliveira, Nicole Cristine Rigonato de |
contributor_str_mv |
Vieira, Rodolfo de Paula Carvalho, Regiane Albertini de Vieira, Rodolfo de Paula Romanholo, Beatriz Mangueira Saraiva Oliveira, Lu??s Vicente Franco de |
dc.subject.por.fl_str_mv |
exerc??cio aer??bio s??ndrome do desconforto respirat??rio agudo interleucina-10 receptor toll like 4 receptor toll like 7 SOD |
topic |
exerc??cio aer??bio s??ndrome do desconforto respirat??rio agudo interleucina-10 receptor toll like 4 receptor toll like 7 SOD aerobic exercise acute respiratory distress syndrome interleukin-10 toll like receptor 4 toll like receptor 7 SOD CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
aerobic exercise acute respiratory distress syndrome interleukin-10 toll like receptor 4 toll like receptor 7 SOD |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
The acute respiratory distress syndrome (ARDS) is a disease characterized by respiratory failure due to an inflammatory response, which has high morbidity and mortality. Several cytokines seem to orchestrate the acute and chronic processes, mainly mediated by toll like receptors (TLRs). The literature demonstrates that aerobic exercise (AE) is capable of decreasing the secretion of pro-inflammatory cytokines in the lungs mediated increased release of interleukin 10 (IL-10), and AE modulate expression of TLRs and antioxidant enzymes. The objective of this study was to evaluate whether the anti-inflammatory effects of AE in an experimental model of intra and extrapulmonary ARDS are mediated by IL-10. For this, the animals were subjected to physical training on a treadmill, moderate for 4 weeks. 24 hours after the last physical test, animals received LPS by intratracheally (it) (10ug / animal) or intraperitoneally (ip) (100ug / animal). After 24 hours, the animals were assessed for the number of cells and pro- and anti-inflammatory cytokines in bronchoalveolar lavage fluid (BAL) and serum were the number of neutrophils in the lung parenchyma and expression of TLR4, TLR7, SOD, ??nion and QL in lung homogenates. AE reduced accumulation of neutrophils in the lung parenchyma, so it LPS and LPS ip (p <0.01) and BAL (p <0.01). AE attenuate the levels of proinflammatory cytokines in BAL and serum (p <0.05), as measured by ELISA. AE had levels of anti-inflammatory cytokine IL-10 increased in the serum and BAL (p <0.05). AE also reduced the expression of TLR4 in lung homogenates (p <0.05) and increased the expression of TLR7 in group LPS + AE evaluated by western blotting (p <0.05). The results for the antioxidant enzyme SOD showed a significant increase in the groups submitted to AE. It follows that the impact of reduced LPS-induced ARDS, regardless of etiology, and these effects appear to be mediated by modulation of the AE secretion of anti-inflammatory cytokines, especially IL-10, modulating TLR4 and TLR7 and increased expression of SOD (p <0.05). |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-12-19 |
dc.date.accessioned.fl_str_mv |
2016-05-25T16:04:47Z |
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info:eu-repo/semantics/publishedVersion |
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dc.identifier.citation.fl_str_mv |
Oliveira, Nicole Cristine Rigonato de. Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental. 2014. 81 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho,S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1344 |
identifier_str_mv |
Oliveira, Nicole Cristine Rigonato de. Avalia????o do papel da IL-10 nos efeitos anti-inflamat??rios do exerc??cio aer??bio na s??ndrome do desconforto respirat??rio agudo experimental. 2014. 81 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho,S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1344 |
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por |
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Universidade Nove de Julho |
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Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o |
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UNINOVE |
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Universidade Nove de Julho |
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