Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato

Detalhes bibliográficos
Autor(a) principal: Ferreira, Tereza Cristina dos Reis
Data de Publicação: 2018
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da Uninove
Texto Completo: http://bibliotecatede.uninove.br/handle/tede/2307
Resumo: Physical activity, whether systematized and with professional or non-professional follow-up, is directly related to quality of life and disease prevention. However, accompanied by this growth, the number of muscular injuries was also increased. Muscle injuries can be caused by bruising, stretches or lacerations. More than 90% of all sports-related injuries are bruises or sprains. Foccusing on preventive care to reduce the risk of injury, exposure to photobiomodulation therapy (PBMT), pre- or post-activity, can protect vulnerable tissues to exercise-induced damage and speeding up recovery. It provides unique, non-invasive and non-pharmacological approach to reducing muscle fatigue. Andiroba (Carapa guianensis) is a medicinal plant traditionally used in the Brazilian Amazon region with known anti-inflammatory activity and extensive indication in skin diseases. Andiroba oil is rich in essential fatty acids, including linoleic acid wich has effect on lipid transport and metabolism in vivo, as well as for maintaining the function and integrity of cell membranes. The aim of this study was to analyze the effects of PBMT and andiroba oil on oxidative stress markers, histological analysis and proinflmmatory cytokine levels from rats after injury to the anterior tibialis muscle. Rats treated with PBMT plus andiroba oil (50% concentration) showed a reduction in lipid peroxidation 6 and 24 hours after muscle damage. Increased of glutathione peroxidase was observed in PBMT group, and increased superoxide dismutase in PBMT and PBMT plus andiroba oil 48 hours post-injury. The histological analysis showed discrete edema in the PBMT and PBMT plus andiroba oil groups. Necrosis was observed only in the group with tissue injury. A statistically significant reduction in IL-6 and TNF-α were observed 6, 24 e 48 hours after injury in the PBMT plus andiroba oil group. Our findings suggest a positive association of PBMT and andiroba oil in decrease the production of inflammatory mediators. However, further studies are necessary in order to conclude the positive assotiation between PBMT and andiroba oil. This fact may favor riparian communities that already uses andiroba oil on a daily basis injuries, as well as to provide to the scientific Community with new treatment options, since the anti-inflammatory effects of PBMT are not questionable, but its association with medicinal plants is still a new therapeutic aproach, with low costs and low side effects.
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spelling Leal Junior, Ernesto Cesar Pintokietzer, Kátia SimoneLeal Junior, Ernesto Cesar PintoMiranda, Eduardo FoschiniCaslechi, Heliodora LeãoFrigo , Luciohttp://lattes.cnpq.br/5561099358324105Ferreira, Tereza Cristina dos Reis2020-10-28T18:51:25Z2018-06-11Ferreira, Tereza Cristina dos Reis. Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato. 2018. 72 f. Tese( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, 2018.http://bibliotecatede.uninove.br/handle/tede/2307Physical activity, whether systematized and with professional or non-professional follow-up, is directly related to quality of life and disease prevention. However, accompanied by this growth, the number of muscular injuries was also increased. Muscle injuries can be caused by bruising, stretches or lacerations. More than 90% of all sports-related injuries are bruises or sprains. Foccusing on preventive care to reduce the risk of injury, exposure to photobiomodulation therapy (PBMT), pre- or post-activity, can protect vulnerable tissues to exercise-induced damage and speeding up recovery. It provides unique, non-invasive and non-pharmacological approach to reducing muscle fatigue. Andiroba (Carapa guianensis) is a medicinal plant traditionally used in the Brazilian Amazon region with known anti-inflammatory activity and extensive indication in skin diseases. Andiroba oil is rich in essential fatty acids, including linoleic acid wich has effect on lipid transport and metabolism in vivo, as well as for maintaining the function and integrity of cell membranes. The aim of this study was to analyze the effects of PBMT and andiroba oil on oxidative stress markers, histological analysis and proinflmmatory cytokine levels from rats after injury to the anterior tibialis muscle. Rats treated with PBMT plus andiroba oil (50% concentration) showed a reduction in lipid peroxidation 6 and 24 hours after muscle damage. Increased of glutathione peroxidase was observed in PBMT group, and increased superoxide dismutase in PBMT and PBMT plus andiroba oil 48 hours post-injury. The histological analysis showed discrete edema in the PBMT and PBMT plus andiroba oil groups. Necrosis was observed only in the group with tissue injury. A statistically significant reduction in IL-6 and TNF-α were observed 6, 24 e 48 hours after injury in the PBMT plus andiroba oil group. Our findings suggest a positive association of PBMT and andiroba oil in decrease the production of inflammatory mediators. However, further studies are necessary in order to conclude the positive assotiation between PBMT and andiroba oil. This fact may favor riparian communities that already uses andiroba oil on a daily basis injuries, as well as to provide to the scientific Community with new treatment options, since the anti-inflammatory effects of PBMT are not questionable, but its association with medicinal plants is still a new therapeutic aproach, with low costs and low side effects.A atividade física, sistematizada e com acompanhamento profissional ou não profissional, está diretamente relacionada à qualidade de vida e à prevenção de doenças. No entanto, acompanhado desse crescimento, o número de lesões musculares também foi aumentado. Lesões musculares podem ser causadas por contusões, estiramentos ou lacerações. Mais de 90% de todas as lesões relacionadas a esportes são contusões ou estiramento. Concentrar-se em cuidados preventivos para reduzir o risco de lesão, a exposição à terapia de fotobiomodulação (TFBM), antes ou depois da atividade, pode proteger os tecidos vulneráveis dos danos induzidos pelo exercício e acelerar a recuperação. Fornece uma abordagem única, não invasiva e não farmacológica para reduzir a fadiga muscular. A andiroba (Carapa guianensis) é uma planta medicinal tradicionalmente utilizada na Amazônia brasileira com conhecida atividade anti-inflamatória e ampla indicação em doenças de pele. O óleo de andiroba é rico em ácidos graxos essenciais, incluindo o ácido linoléico, que tem efeito sobre o transporte lipídico e o metabolismo in vivo, bem como para manter a função e a integridade das membranas celulares. O objetivo deste estudo foi analisar os efeitos da TFBM e óleo de andiroba sobre marcadores de estresse oxidativo, análise histológica e níveis de citocinas pró-inflamatórias de ratos após lesão do músculo tibial anterior. Ratos tratados com TFBM e óleo de andiroba (concentração de 50%) apresentaram redução na peroxidação lipídica 6 e 24 horas após o dano muscular. O aumento da glutationa peroxidase foi observado no grupo TFBM, e aumentou a superóxido dismutase em TFBM e TFBM mais óleo de andiroba 48 horas após a lesão. A análise histológica mostrou discreto edema nos grupos TFBM e TFBM e óleo de andiroba. A necrose foi observada apenas no grupo com lesão tecidual. Uma redução estatisticamente significante de IL-6 e TNF-α foi observada 6, 24 e 48 horas após a lesão no grupo TFBM e óleo de andiroba. Nossos achados sugerem uma associação positiva de TFBM e óleo de andiroba na diminuição da produção de mediadores inflamatórios. No entanto, mais estudos são necessários para concluir a associação positiva entre TFBM e óleo de andiroba. Este fato pode favorecer as comunidades ribeirinhas que já utilizam o óleo de andiroba diariamente, além de proporcionar à comunidade científica novas opções de tratamento, uma vez que os efeitos antiinflamatórios da TFBM não são questionáveis, mas sua associação com plantas medicinais é questionável. ainda uma nova abordagem terapêutica, com baixos custos e baixos efeitos colaterais.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2020-10-28T18:51:25Z No. of bitstreams: 1 TEREZA CRISTINA DOS REIS FERREIRA.DOCX.pdf: 1120251 bytes, checksum: 9bb64247600c09edea023dec2fe56885 (MD5)Made available in DSpace on 2020-10-28T18:51:25Z (GMT). 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dc.title.por.fl_str_mv Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
dc.title.alternative.eng.fl_str_mv The effects of photobiomodulation therapy and andiroba (Carapa guianensis) on muscle injury by contusion in the tibial anterior rat
title Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
spellingShingle Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
Ferreira, Tereza Cristina dos Reis
terapia por fotobiomodulação
fototerapia
lesão muscular
contusão
andiroba
andiroba
photobiomodulation therapy
phototherapy
skeletal muscle injury
contusion
CIENCIAS DA SAUDE
title_short Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
title_full Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
title_fullStr Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
title_full_unstemmed Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
title_sort Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato
author Ferreira, Tereza Cristina dos Reis
author_facet Ferreira, Tereza Cristina dos Reis
author_role author
dc.contributor.advisor1.fl_str_mv Leal Junior, Ernesto Cesar Pinto
dc.contributor.advisor-co1.fl_str_mv kietzer, Kátia Simone
dc.contributor.referee1.fl_str_mv Leal Junior, Ernesto Cesar Pinto
dc.contributor.referee2.fl_str_mv Miranda, Eduardo Foschini
dc.contributor.referee3.fl_str_mv Caslechi, Heliodora Leão
dc.contributor.referee4.fl_str_mv Frigo , Lucio
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5561099358324105
dc.contributor.author.fl_str_mv Ferreira, Tereza Cristina dos Reis
contributor_str_mv Leal Junior, Ernesto Cesar Pinto
kietzer, Kátia Simone
Leal Junior, Ernesto Cesar Pinto
Miranda, Eduardo Foschini
Caslechi, Heliodora Leão
Frigo , Lucio
dc.subject.por.fl_str_mv terapia por fotobiomodulação
fototerapia
lesão muscular
contusão
andiroba
andiroba
topic terapia por fotobiomodulação
fototerapia
lesão muscular
contusão
andiroba
andiroba
photobiomodulation therapy
phototherapy
skeletal muscle injury
contusion
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv photobiomodulation therapy
phototherapy
skeletal muscle injury
contusion
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description Physical activity, whether systematized and with professional or non-professional follow-up, is directly related to quality of life and disease prevention. However, accompanied by this growth, the number of muscular injuries was also increased. Muscle injuries can be caused by bruising, stretches or lacerations. More than 90% of all sports-related injuries are bruises or sprains. Foccusing on preventive care to reduce the risk of injury, exposure to photobiomodulation therapy (PBMT), pre- or post-activity, can protect vulnerable tissues to exercise-induced damage and speeding up recovery. It provides unique, non-invasive and non-pharmacological approach to reducing muscle fatigue. Andiroba (Carapa guianensis) is a medicinal plant traditionally used in the Brazilian Amazon region with known anti-inflammatory activity and extensive indication in skin diseases. Andiroba oil is rich in essential fatty acids, including linoleic acid wich has effect on lipid transport and metabolism in vivo, as well as for maintaining the function and integrity of cell membranes. The aim of this study was to analyze the effects of PBMT and andiroba oil on oxidative stress markers, histological analysis and proinflmmatory cytokine levels from rats after injury to the anterior tibialis muscle. Rats treated with PBMT plus andiroba oil (50% concentration) showed a reduction in lipid peroxidation 6 and 24 hours after muscle damage. Increased of glutathione peroxidase was observed in PBMT group, and increased superoxide dismutase in PBMT and PBMT plus andiroba oil 48 hours post-injury. The histological analysis showed discrete edema in the PBMT and PBMT plus andiroba oil groups. Necrosis was observed only in the group with tissue injury. A statistically significant reduction in IL-6 and TNF-α were observed 6, 24 e 48 hours after injury in the PBMT plus andiroba oil group. Our findings suggest a positive association of PBMT and andiroba oil in decrease the production of inflammatory mediators. However, further studies are necessary in order to conclude the positive assotiation between PBMT and andiroba oil. This fact may favor riparian communities that already uses andiroba oil on a daily basis injuries, as well as to provide to the scientific Community with new treatment options, since the anti-inflammatory effects of PBMT are not questionable, but its association with medicinal plants is still a new therapeutic aproach, with low costs and low side effects.
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dc.date.issued.fl_str_mv 2018-06-11
dc.date.accessioned.fl_str_mv 2020-10-28T18:51:25Z
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dc.identifier.citation.fl_str_mv Ferreira, Tereza Cristina dos Reis. Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato. 2018. 72 f. Tese( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, 2018.
dc.identifier.uri.fl_str_mv http://bibliotecatede.uninove.br/handle/tede/2307
identifier_str_mv Ferreira, Tereza Cristina dos Reis. Os efeitos da terapia por fotobiomodulaçao e da andiroba (Carapa guianensis) na lesão muscular induzida por contusão no músculo tibial anteror de rato. 2018. 72 f. Tese( Programa de Pós-Graduação em Ciências da Reabilitação) - Universidade Nove de Julho, 2018.
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