Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2612 |
Resumo: | Oral Lichen planus (OLP) is a relatively common chronic mucocutaneous inflammatory disease, characterized by three clinical aspects, called reticular, Atrophic and erosive. In LPO treatment Default Is the use of topical and systemic corticosteroids, which are associated with clinical improvement of the lesion and decreased pain. As an alternative to the treatment of OLP. Some studies have evaluated the efficacy of the FBM in reducing the size of the lesion and pain intensity. Thus, this study aims to compare the efficacy of Laser treatment at low intensity LBI (660nm) in relation to corticosteroid therapy in oral lichen planus. Patients with diagnosis of OLP were distributed in two group: in control grup( corticosteroid treatment) and experimental group( treatment with FBM).Pacients to be evaluated in the D0, D7, D14, D21, D30 and D60. Clinical evaluation included clinical characteristic and size of the lesion, quality of life questionnaire, the scores of the resolution of the injury and recurrence. In clinical scores, no statistically significant no statistically difference was observed between the corticoid and FBM groups. A descriptive analysis of the data was performed, both in the Corticoid group and in the FBM group were able to decrease the functional aspects (Chewing, swallowing, fluid intake and taste). Most lesions of both the Corticoid group and the FBM group presented complete resolution in the D30. The efficacy of the treatment observed That there was a slight improvement in the OLP lesions after treatment in the Corticoid group in 1/8 patients, moderate and significant improvement in 3 patients and still, 1 patient did not respond to treatment. In the FBM group, mild and moderate improvement was observed in 1 and 6 patients, respectively, and one patient had total resolution of the disease and 2 patients did not respond to treatment. At the beginning And at the end of treatment, as well as 30 days after the end of treatment No statistically significant difference was observed in relation To the total score of the OHIP-14 questionnaire between the corticoid and FBM groups. No recurrence of OLP lesions was observed in patients in the Corticoid group And in the Group FBM. |
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Rodrigues, Maria Fernanda Setúbal Destrohttp://lattes.cnpq.br/7153553682954852Rodrigues, Maria Fernanda Setúbal Destrohttp://lattes.cnpq.br/7153553682954852Silva, Daniela de Fatima Teixeira dahttp://lattes.cnpq.br/5912729434641689Gallo, Camila de Barroshttp://lattes.cnpq.br/6883084382927121http://lattes.cnpq.br/5268899710126257Ferri, Elza Padilha2021-10-22T22:48:11Z2019-01-29Ferri, Elza Padilha. Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego. 2019.96 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2612Oral Lichen planus (OLP) is a relatively common chronic mucocutaneous inflammatory disease, characterized by three clinical aspects, called reticular, Atrophic and erosive. In LPO treatment Default Is the use of topical and systemic corticosteroids, which are associated with clinical improvement of the lesion and decreased pain. As an alternative to the treatment of OLP. Some studies have evaluated the efficacy of the FBM in reducing the size of the lesion and pain intensity. Thus, this study aims to compare the efficacy of Laser treatment at low intensity LBI (660nm) in relation to corticosteroid therapy in oral lichen planus. Patients with diagnosis of OLP were distributed in two group: in control grup( corticosteroid treatment) and experimental group( treatment with FBM).Pacients to be evaluated in the D0, D7, D14, D21, D30 and D60. Clinical evaluation included clinical characteristic and size of the lesion, quality of life questionnaire, the scores of the resolution of the injury and recurrence. In clinical scores, no statistically significant no statistically difference was observed between the corticoid and FBM groups. A descriptive analysis of the data was performed, both in the Corticoid group and in the FBM group were able to decrease the functional aspects (Chewing, swallowing, fluid intake and taste). Most lesions of both the Corticoid group and the FBM group presented complete resolution in the D30. The efficacy of the treatment observed That there was a slight improvement in the OLP lesions after treatment in the Corticoid group in 1/8 patients, moderate and significant improvement in 3 patients and still, 1 patient did not respond to treatment. In the FBM group, mild and moderate improvement was observed in 1 and 6 patients, respectively, and one patient had total resolution of the disease and 2 patients did not respond to treatment. At the beginning And at the end of treatment, as well as 30 days after the end of treatment No statistically significant difference was observed in relation To the total score of the OHIP-14 questionnaire between the corticoid and FBM groups. No recurrence of OLP lesions was observed in patients in the Corticoid group And in the Group FBM.Líquen Plano Oral (LPO) é uma doença inflamatória mucocutânea crônica relativamente comum, caracterizada por três aspectos clínicos, denominados reticular, atrófico e erosivo. No LPO o tratamento padrão é o uso de corticoides tópicos e sistêmicos, os quais estão associados com melhora clínica da lesão e diminuição da dor. Como alternativa para o tratamento do LPO alguns estudos têm avaliado a eficácia da FBM na redução do tamanho da lesão, na intensidade da dor. Assim, este estudo tem como objetivo comparar a eficácia do tratamento com Laser em baixa intensidade (LBI) (660nm) em relação à corticoterapia no líquen plano oral. Pacientes com diagnóstico de LPO foram distribuídos em dois grupos: grupo controle (tratamento com corticóide) e grupo experimental (tratamento com FBM). Os pacientes serão avaliados no D0, D7, D14, D21, D30 e D60. A avaliação clínica incluiu característica clínica e tamanho da lesão, escores funcionais, dor e desconforto, questionário de qualidade de vida, escores da resolução da lesão e recorrência. Nos escores clínicos não foi observada diferença estatística significante entre os grupos Corticóide e FBM. Foi realizada uma análise descritiva dos dados, tanto no grupo corticoide como no grupo FBM foram capazes de diminuir os aspectos funcionais (mastigação, deglutição, ingestão de líquidos e paladar). A maioria das lesões tanto do grupo Corticóide quanto do grupo FBM apresentaram resolução completa no D30. Na eficácia do tratamento observou que houve melhora discreta das lesões de LPO após o tratamento no grupo Corticóide em 1/8 pacientes, melhora moderada e significativa em 3 pacientes e ainda, 1 paciente não respondeu ao tratamento. Já no grupo FBM, melhora discreta e moderada foi observada em 1 e 6 pacientes respectivamente, sendo que 1 paciente obteve resolução total da doença e 2 pacientes não responderam ao tratamento. No início e no término do tratamento, bem como após 30 dias do término do tratamento não foi observada diferença estatística significante em relação ao escore total do questionário OHIP-14 entre os grupos Corticóide e FBM. Não foi observada recorrência das lesões de LPO nos pacientes do grupo Corticóide e no grupo FBM.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-10-22T22:48:11Z No. of bitstreams: 1 Elza Padilha Ferri.pdf: 4653975 bytes, checksum: db26dae01c5a4200dff765579d80b7ba (MD5)Made available in DSpace on 2021-10-22T22:48:11Z (GMT). No. of bitstreams: 1 Elza Padilha Ferri.pdf: 4653975 bytes, checksum: db26dae01c5a4200dff765579d80b7ba (MD5) Previous issue date: 2019-01-29application/pdfporUniversidade Nove de JulhoPrograma de Pós-Graduação em Biofotônica Aplicada às Ciências da SaúdeUNINOVEBrasilSaúdelíquen-plano oralfotobiomodulaçãocorticóidedorcaracterísticas clínicasqualidade de vidaclinical characteristicsquality of lifeoral lichen-planusphotobiomodulationcorticoidpainCIENCIAS DA SAUDEEficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cegoEfficacy of photobiomodulation in the treatment of oral lichen planus: a clinical, randomized, controlled, double blindinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALElza Padilha Ferri.pdfElza Padilha Ferri.pdfapplication/pdf4653975http://localhost:8080/tede/bitstream/tede/2612/2/Elza+Padilha+Ferri.pdfdb26dae01c5a4200dff765579d80b7baMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2612/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/26122021-10-22 20:48:11.609oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2021-10-22T22:48:11Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego |
dc.title.alternative.eng.fl_str_mv |
Efficacy of photobiomodulation in the treatment of oral lichen planus: a clinical, randomized, controlled, double blind |
title |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego |
spellingShingle |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego Ferri, Elza Padilha líquen-plano oral fotobiomodulação corticóide dor características clínicas qualidade de vida clinical characteristics quality of life oral lichen-planus photobiomodulation corticoid pain CIENCIAS DA SAUDE |
title_short |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego |
title_full |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego |
title_fullStr |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego |
title_full_unstemmed |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego |
title_sort |
Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego |
author |
Ferri, Elza Padilha |
author_facet |
Ferri, Elza Padilha |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Rodrigues, Maria Fernanda Setúbal Destro |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7153553682954852 |
dc.contributor.referee1.fl_str_mv |
Rodrigues, Maria Fernanda Setúbal Destro |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/7153553682954852 |
dc.contributor.referee2.fl_str_mv |
Silva, Daniela de Fatima Teixeira da |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5912729434641689 |
dc.contributor.referee3.fl_str_mv |
Gallo, Camila de Barros |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/6883084382927121 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5268899710126257 |
dc.contributor.author.fl_str_mv |
Ferri, Elza Padilha |
contributor_str_mv |
Rodrigues, Maria Fernanda Setúbal Destro Rodrigues, Maria Fernanda Setúbal Destro Silva, Daniela de Fatima Teixeira da Gallo, Camila de Barros |
dc.subject.por.fl_str_mv |
líquen-plano oral fotobiomodulação corticóide dor características clínicas qualidade de vida clinical characteristics quality of life |
topic |
líquen-plano oral fotobiomodulação corticóide dor características clínicas qualidade de vida clinical characteristics quality of life oral lichen-planus photobiomodulation corticoid pain CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
oral lichen-planus photobiomodulation corticoid pain |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Oral Lichen planus (OLP) is a relatively common chronic mucocutaneous inflammatory disease, characterized by three clinical aspects, called reticular, Atrophic and erosive. In LPO treatment Default Is the use of topical and systemic corticosteroids, which are associated with clinical improvement of the lesion and decreased pain. As an alternative to the treatment of OLP. Some studies have evaluated the efficacy of the FBM in reducing the size of the lesion and pain intensity. Thus, this study aims to compare the efficacy of Laser treatment at low intensity LBI (660nm) in relation to corticosteroid therapy in oral lichen planus. Patients with diagnosis of OLP were distributed in two group: in control grup( corticosteroid treatment) and experimental group( treatment with FBM).Pacients to be evaluated in the D0, D7, D14, D21, D30 and D60. Clinical evaluation included clinical characteristic and size of the lesion, quality of life questionnaire, the scores of the resolution of the injury and recurrence. In clinical scores, no statistically significant no statistically difference was observed between the corticoid and FBM groups. A descriptive analysis of the data was performed, both in the Corticoid group and in the FBM group were able to decrease the functional aspects (Chewing, swallowing, fluid intake and taste). Most lesions of both the Corticoid group and the FBM group presented complete resolution in the D30. The efficacy of the treatment observed That there was a slight improvement in the OLP lesions after treatment in the Corticoid group in 1/8 patients, moderate and significant improvement in 3 patients and still, 1 patient did not respond to treatment. In the FBM group, mild and moderate improvement was observed in 1 and 6 patients, respectively, and one patient had total resolution of the disease and 2 patients did not respond to treatment. At the beginning And at the end of treatment, as well as 30 days after the end of treatment No statistically significant difference was observed in relation To the total score of the OHIP-14 questionnaire between the corticoid and FBM groups. No recurrence of OLP lesions was observed in patients in the Corticoid group And in the Group FBM. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-01-29 |
dc.date.accessioned.fl_str_mv |
2021-10-22T22:48:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Ferri, Elza Padilha. Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego. 2019.96 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2612 |
identifier_str_mv |
Ferri, Elza Padilha. Eficácia da fotobiomodulação no tratamento do líquen plano oral: estudo clínico, randomizado, controlado e duplo cego. 2019.96 f. Tese( Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde) - Universidade Nove de Julho, São Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/2612 |
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por |
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Programa de Pós-Graduação em Biofotônica Aplicada às Ciências da Saúde |
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UNINOVE |
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Brasil |
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Saúde |
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Universidade Nove de Julho |
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