Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1317 |
Resumo: | The tendinopathy are changes in the health of the tendon, usually frequent and difficult to treat (Langberg and Kongs-GAARD, 2008), requiring considerable financial resources for its treatment.The main objective of the tendon healing process is the restoration of mechanical strength, since the injury induces changes in these mechanical properties. For the assessment of these changes, some models are used, including the monotonic traction tests to failure of the tissue that provide important information about the stiffness and elongation, assisting in the understanding of functional aspects in the progression of the lesion, determining the biomechanical aspects of therapies used for tissue repair. OBJECTIVES: Evaluate the low-level laser action (830nm) and its association with pharmacotherapy using diclofenac sodium in tissue repair tendon, analyzing their mechanical behavior and histological aspects.The animals were anesthetized by intraperitoneal injection of ketamine hydrochloride (90mg / kg) and xylazine (10mg / kg). Then the control animals received as vehicle a transcutaneous injection with 100 mL of sterile saline 0.9% NaCl in the posterior region of the right foot, the Achilles tendon. The animals of the other groups received 100 of transcutaneous injection of collagenase (1 mg / ml;. Sigma Chemical Co, Cat C-6885) in the same region of the Achilles tendon. Next, the animals returned to the containment boxes separated into 5 experimental groups with 7 animals per group: - Control group (CTL): 100 ??L was injected of sterile saline (0.9%) in Peritendinous region of the Achilles tendon. - Tendonitis Group untreated (NT): 100 ??l was injected Collagenase (1 mg / ml) in Peritendinous region of the Achilles tendon. Diclofenac group (DIC): 100 ??l was injected of Collagenase (1 mg / ml) in Peritendinous region of the Achilles tendon. Immediately after injury, the anti-inflammatory diclofenac sodium was injected (1 mg / kg IM).From our results we can conclude that tendinitis promotes histological changes leading to biomechanical changes translating into weakening of the tendon tissue. Pharmacologic therapy with diclofenac sodium improves some mechanical properties, reducing the loss of the maximum traction strength, but the histological aspects are far from healthy tendon. Low power laser therapy also improved both the histological appearance as a functional feature translated by the improvement in maximum traction strength. The association between laser and pharmacological therapies changed histological and biomechanical aspects of the tendon, increasing the deformability due to the increase in displacement at the time of breakage. |
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Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Frigo, L??ciohttp://lattes.cnpq.br/8191788652250529Leal Junior, Ernesto Cesar Pintohttp://lattes.cnpq.br/8166626486201116http://lattes.cnpq.br/6958646930396501Faria, Raquel Santos de2016-05-19T18:01:17Z2014-12-16Faria, Raquel Santos de. Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos. 2014. 57 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1317The tendinopathy are changes in the health of the tendon, usually frequent and difficult to treat (Langberg and Kongs-GAARD, 2008), requiring considerable financial resources for its treatment.The main objective of the tendon healing process is the restoration of mechanical strength, since the injury induces changes in these mechanical properties. For the assessment of these changes, some models are used, including the monotonic traction tests to failure of the tissue that provide important information about the stiffness and elongation, assisting in the understanding of functional aspects in the progression of the lesion, determining the biomechanical aspects of therapies used for tissue repair. OBJECTIVES: Evaluate the low-level laser action (830nm) and its association with pharmacotherapy using diclofenac sodium in tissue repair tendon, analyzing their mechanical behavior and histological aspects.The animals were anesthetized by intraperitoneal injection of ketamine hydrochloride (90mg / kg) and xylazine (10mg / kg). Then the control animals received as vehicle a transcutaneous injection with 100 mL of sterile saline 0.9% NaCl in the posterior region of the right foot, the Achilles tendon. The animals of the other groups received 100 of transcutaneous injection of collagenase (1 mg / ml;. Sigma Chemical Co, Cat C-6885) in the same region of the Achilles tendon. Next, the animals returned to the containment boxes separated into 5 experimental groups with 7 animals per group: - Control group (CTL): 100 ??L was injected of sterile saline (0.9%) in Peritendinous region of the Achilles tendon. - Tendonitis Group untreated (NT): 100 ??l was injected Collagenase (1 mg / ml) in Peritendinous region of the Achilles tendon. Diclofenac group (DIC): 100 ??l was injected of Collagenase (1 mg / ml) in Peritendinous region of the Achilles tendon. Immediately after injury, the anti-inflammatory diclofenac sodium was injected (1 mg / kg IM).From our results we can conclude that tendinitis promotes histological changes leading to biomechanical changes translating into weakening of the tendon tissue. Pharmacologic therapy with diclofenac sodium improves some mechanical properties, reducing the loss of the maximum traction strength, but the histological aspects are far from healthy tendon. Low power laser therapy also improved both the histological appearance as a functional feature translated by the improvement in maximum traction strength. The association between laser and pharmacological therapies changed histological and biomechanical aspects of the tendon, increasing the deformability due to the increase in displacement at the time of breakage.As tendinopatias s??o altera????es na sa??de do tend??o, geralmente frequentes e dif??ceis de serem tratadas, com uma variedade de terapias e tratamentos e o mais utilizado ?? o farmacol??gico para o al??vio da dor com resultados pouco satisfat??rios devido aos seus efeitos indesej??veis no uso prolongado. A busca de novas terapias n??o farmacol??gicas no tratamento destas doen??as bem como o entendimento das associa????es entre terapia farmacol??gica e n??o farmacol??gica assume papel de destaque na ??rea m??dica. A terapia com laser de baixa pot??ncia aparece como terapia promissora na modula????o do processo inflamat??rio agudo e cr??nico com aus??ncia de efeitos adversos. No entanto, o estabelecimento de par??metros cl??nicos para a utiliza????o desta t??cnica ?? extremamente importante para sua valida????o. Objetivo: O objetivo do trabalho foi estudar o efeito do laser de baixa pot??ncia e sua associa????o com anti-inflamat??rio Diclofenaco de s??dio, no reparo do tend??o ap??s a indu????o da tendinite pela inje????o de colagenase, investigando aspectos histol??gicos e biomec??nicos. Material e m??todos: Foram utilizados ratos Wistar machos pesando entre 150 e 200g, provenientes do Biot??rio da UNINOVE Comit?? de ??tica AN0037/2013. Os animais foram separados em 5 grupos: Controle, com tend??o saud??vel (CTL), Tendinite n??o tratado (NT), Tendinite e tratado com Diclofenaco de s??dio (DIC), Tendinite e tratado com Laser de baixa pot??ncia (L3J) e Tendinite e tratado com associa????o de Diclofenaco e Laser (D+L). Para indu????o da tendinite os animais dos grupos NT, DIC, L3J e D+L foram anestesiados e receberam inje????o transcut??nea de colagenase (100??g/animal) na regi??o posterior da pata direita, no tend??o calc??neo. Os tratamentos iniciaram imediatamente ?? indu????o da tendinite e continuaram diariamente at?? o 7?? dia. Ap??s 28 dias os animais foram eutanasiados e o tend??o foi removido para an??lises histol??gicas e de propriedades mec??nicas. Resultados e Discuss??o: Os animais do grupo NT apresentaram altera????es na organiza????o do col??geno e redu????o da for??a m??xima de tra????o. Tanto o grupo DIC quanto o L3J apresentaram melhora da for??a m??xima de tra????o. O grupo DIC apresentou discreto aumento da rigidez enquanto que o grupo L3J apresentou organiza????o de col??geno mais pr??ximo ao grupo CTL. O grupo D+L apresentou aumento da capacidade de deforma????o e altera????es histol??gicas. Conclus??o: A terapia com laser de baixa pot??ncia melhorou o reparo do tend??o ap??s a indu????o da tendinite. O tratamento com diclofenaco aumentou discretamente a rigidez do tecido. O tratamento farmacol??gico pelo Diclofenaco de s??dio associado a laserterapia aumentou a capacidade de deforma????o do tend??o, por??m, com menor for??a de tra????o.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-19T18:01:17Z No. of bitstreams: 1 Raquel Santos de Faria.doc: 12783104 bytes, checksum: 4980beadad8794c67cfd474377a224ff (MD5)Made available in DSpace on 2016-05-19T18:01:17Z (GMT). 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dc.title.por.fl_str_mv |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos |
dc.title.alternative.por.fl_str_mv |
Effect of the association of laser therapy and pharmacotherapy in tendon with acute inflammation model induced by collagenase in rats |
title |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos |
spellingShingle |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos Faria, Raquel Santos de tendinite laserterapia colagenase propriedades mec??nicas tendinitis cllagenase LLLT mechanical properties CIENCIAS DA SAUDE |
title_short |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos |
title_full |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos |
title_fullStr |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos |
title_full_unstemmed |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos |
title_sort |
Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos |
author |
Faria, Raquel Santos de |
author_facet |
Faria, Raquel Santos de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee1.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee2.fl_str_mv |
Frigo, L??cio |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/8191788652250529 |
dc.contributor.referee3.fl_str_mv |
Leal Junior, Ernesto Cesar Pinto |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/8166626486201116 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6958646930396501 |
dc.contributor.author.fl_str_mv |
Faria, Raquel Santos de |
contributor_str_mv |
Marcos, Rodrigo Labat Marcos, Rodrigo Labat Frigo, L??cio Leal Junior, Ernesto Cesar Pinto |
dc.subject.por.fl_str_mv |
tendinite laserterapia colagenase propriedades mec??nicas |
topic |
tendinite laserterapia colagenase propriedades mec??nicas tendinitis cllagenase LLLT mechanical properties CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
tendinitis cllagenase LLLT mechanical properties |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
The tendinopathy are changes in the health of the tendon, usually frequent and difficult to treat (Langberg and Kongs-GAARD, 2008), requiring considerable financial resources for its treatment.The main objective of the tendon healing process is the restoration of mechanical strength, since the injury induces changes in these mechanical properties. For the assessment of these changes, some models are used, including the monotonic traction tests to failure of the tissue that provide important information about the stiffness and elongation, assisting in the understanding of functional aspects in the progression of the lesion, determining the biomechanical aspects of therapies used for tissue repair. OBJECTIVES: Evaluate the low-level laser action (830nm) and its association with pharmacotherapy using diclofenac sodium in tissue repair tendon, analyzing their mechanical behavior and histological aspects.The animals were anesthetized by intraperitoneal injection of ketamine hydrochloride (90mg / kg) and xylazine (10mg / kg). Then the control animals received as vehicle a transcutaneous injection with 100 mL of sterile saline 0.9% NaCl in the posterior region of the right foot, the Achilles tendon. The animals of the other groups received 100 of transcutaneous injection of collagenase (1 mg / ml;. Sigma Chemical Co, Cat C-6885) in the same region of the Achilles tendon. Next, the animals returned to the containment boxes separated into 5 experimental groups with 7 animals per group: - Control group (CTL): 100 ??L was injected of sterile saline (0.9%) in Peritendinous region of the Achilles tendon. - Tendonitis Group untreated (NT): 100 ??l was injected Collagenase (1 mg / ml) in Peritendinous region of the Achilles tendon. Diclofenac group (DIC): 100 ??l was injected of Collagenase (1 mg / ml) in Peritendinous region of the Achilles tendon. Immediately after injury, the anti-inflammatory diclofenac sodium was injected (1 mg / kg IM).From our results we can conclude that tendinitis promotes histological changes leading to biomechanical changes translating into weakening of the tendon tissue. Pharmacologic therapy with diclofenac sodium improves some mechanical properties, reducing the loss of the maximum traction strength, but the histological aspects are far from healthy tendon. Low power laser therapy also improved both the histological appearance as a functional feature translated by the improvement in maximum traction strength. The association between laser and pharmacological therapies changed histological and biomechanical aspects of the tendon, increasing the deformability due to the increase in displacement at the time of breakage. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-12-16 |
dc.date.accessioned.fl_str_mv |
2016-05-19T18:01:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Faria, Raquel Santos de. Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos. 2014. 57 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1317 |
identifier_str_mv |
Faria, Raquel Santos de. Efeito da associa????o entre laserterapia e farmacoterapia no modelo de inflama????o aguda do tend??o induzida por colagenase em ratos. 2014. 57 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/1317 |
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Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de |
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UNINOVE |
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Universidade Nove de Julho |
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MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1811016868415143936 |