Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/2991 |
Resumo: | Introduction: In view of the increase in life expectancy and the prevalence of diabetes and arterial hypertension, an increase in the elderly population with chronic kidney disease (CKD) has been observed. Vascular calcification is frequent in elderly and in patients with CKD. Some experimental studies have been observed a relationship between Klotho and vascular calcification. Thus, it is possible that Klotho is a risk factor for vascular calcification in patients with CKD. This study proposes the assessment of the association between intracranial vessel calcification and serum Klotho. Methods: This is a subanalysis of CTs performed in a study evaluating the association between cognition with markers of mineral and bone metabolism. We evaluated 60 CTs of patients with stages 4 and 5 CKD not on dialysis. Clinical, biochemical, and demographic data were collected. The CT was reported in a structured way, following the same sequence in all patients. Only vascular but not parenchymal calcification was evaluated. Results: Patients aged 81 7 years (65% men, 93% with hypertension, and 48% with diabetes). The median Klotho concentration was 783 (610, 994) pg/ml. Vascular calcification was observed in 18 patients (30%). Patients with intracranial vascular calcification were not distinguished from those without calcification regarding sex, age, body mass index, blood pressure, albumin, creatinine, cholesterol, calcium, phosphorus, and fibroblast growth factor 23. They had a slightly lower percentage of hypertension (83.3 vs. 96.6%, p = 0.042), and a lower concentration of Klotho [613 (509 - 805) vs. 824 (704, 1042), p = 0.009]. This difference remained significant even after adjusting for age, renal function, and classical cardiovascular risk factors such as diabetes, blood pressure, and cholesterol. Conclusion: Patients with moderate to severe CKD present intracranial vascular calcification in association with lower Klotho concentration. |
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Elias, Rosilene Mottahttp://lattes.cnpq.br/9742090948110017Elias, Rosilene Mottahttp://lattes.cnpq.br/9742090948110017Dalboni, Maria Aparecidahttp://lattes.cnpq.br/9818040147487320Custódio, Melani Ribeirohttp://lattes.cnpq.br/3390801574622152http://lattes.cnpq.br/6735100952659941Carvalho, Luci Carla Dias Batista2022-07-21T15:20:43Z2020-12-17Carvalho, Luci Carla Dias Batista. Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho. 2020. 56 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo.http://bibliotecatede.uninove.br/handle/tede/2991Introduction: In view of the increase in life expectancy and the prevalence of diabetes and arterial hypertension, an increase in the elderly population with chronic kidney disease (CKD) has been observed. Vascular calcification is frequent in elderly and in patients with CKD. Some experimental studies have been observed a relationship between Klotho and vascular calcification. Thus, it is possible that Klotho is a risk factor for vascular calcification in patients with CKD. This study proposes the assessment of the association between intracranial vessel calcification and serum Klotho. Methods: This is a subanalysis of CTs performed in a study evaluating the association between cognition with markers of mineral and bone metabolism. We evaluated 60 CTs of patients with stages 4 and 5 CKD not on dialysis. Clinical, biochemical, and demographic data were collected. The CT was reported in a structured way, following the same sequence in all patients. Only vascular but not parenchymal calcification was evaluated. Results: Patients aged 81 7 years (65% men, 93% with hypertension, and 48% with diabetes). The median Klotho concentration was 783 (610, 994) pg/ml. Vascular calcification was observed in 18 patients (30%). Patients with intracranial vascular calcification were not distinguished from those without calcification regarding sex, age, body mass index, blood pressure, albumin, creatinine, cholesterol, calcium, phosphorus, and fibroblast growth factor 23. They had a slightly lower percentage of hypertension (83.3 vs. 96.6%, p = 0.042), and a lower concentration of Klotho [613 (509 - 805) vs. 824 (704, 1042), p = 0.009]. This difference remained significant even after adjusting for age, renal function, and classical cardiovascular risk factors such as diabetes, blood pressure, and cholesterol. Conclusion: Patients with moderate to severe CKD present intracranial vascular calcification in association with lower Klotho concentration.Introdução: Diante do aumento da expectativa de vida e da prevalência de diabetes e hipertensão arterial, tem-se observado um aumento da população idosa com doença renal crônica (DRC). Calcificações vasculares são frequentes em idosos e em pacientes com DRC. Estudos experimentais apontam a relação entre concentração da proteína Klotho e calcificação vascular. Este estudo propõe a avaliação de calcificação de vasos intracranianos e sua relação com Klotho. Métodos: Esta é uma subanálise de TCs realizadas em um estudo cujo objetivo é avaliar a relação de cognição com marcadores do metabolismo mineral. Foram avaliadas 60 TCs de pacientes portadores de DRC não dialítica (Estágios 4 e 5). Dados clínicos, bioquímicos e demográficos foram coletados. Resultados: A idade média foi de 817 anos (65% homens, 93% com hipertensão arterial e 48% com diabetes). A mediana da concentração de Klotho foi 783 (610, 994) pg/ml. Calcificação vascular foi observada em 18 pacientes (30%). Estes pacientes não se distinguiram dos demais quanto ao sexo, idade, índice de massa corporal, pressão arterial, albumina, creatinina, colesterol, cálcio, fósforo e fator de crescimento de fibroblastos-23. Eles tinham um percentual um menor de hipertensão (83,3 vs. 96,6%, p=0,042) e uma menor concentração de Klotho [613 (509 - 805) vs. 824 (704, 1042), p=0,009]. Esta diferença permaneceu significante após ajuste para idade, função renal e fatores clássicos de risco cardiovascular tais como diabetes, pressão arterial e colesterol. Conclusão: Pacientes idosos com DRC moderada a grave apresentam calcificação vascular intracraniana em associação com menor concentração de Klotho.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2022-07-21T15:20:43Z No. of bitstreams: 1 Luci Carla Dias Carvalho.pdf: 1927365 bytes, checksum: bde7c8bdbbb093bc2bdd7715e29e050b (MD5)Made available in DSpace on 2022-07-21T15:20:43Z (GMT). No. of bitstreams: 1 Luci Carla Dias Carvalho.pdf: 1927365 bytes, checksum: bde7c8bdbbb093bc2bdd7715e29e050b (MD5) Previous issue date: 2020-12-17application/pdfporUniversidade Nove de JulhoPrograma de Mestrado em MedicinaUNINOVEBrasilSaúdedoença renal crônicatomografia de crâniohipertensão arterialklothochronic kidney diseaseskull tomographyarterial hypertensionklothoCIENCIAS DA SAUDECalcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klothoIntracranial vascular calcification in elderly patients with chronic kidney disease: relationship with klothoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALLuci Carla Dias Carvalho.pdfLuci Carla Dias Carvalho.pdfapplication/pdf1927365http://localhost:8080/tede/bitstream/tede/2991/2/Luci+Carla+Dias+Carvalho.pdfbde7c8bdbbb093bc2bdd7715e29e050bMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/2991/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/29912022-07-21 12:20:43.799oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2022-07-21T15:20:43Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho |
dc.title.alternative.eng.fl_str_mv |
Intracranial vascular calcification in elderly patients with chronic kidney disease: relationship with klotho |
title |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho |
spellingShingle |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho Carvalho, Luci Carla Dias Batista doença renal crônica tomografia de crânio hipertensão arterial klotho chronic kidney disease skull tomography arterial hypertension klotho CIENCIAS DA SAUDE |
title_short |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho |
title_full |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho |
title_fullStr |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho |
title_full_unstemmed |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho |
title_sort |
Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho |
author |
Carvalho, Luci Carla Dias Batista |
author_facet |
Carvalho, Luci Carla Dias Batista |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Elias, Rosilene Motta |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9742090948110017 |
dc.contributor.referee1.fl_str_mv |
Elias, Rosilene Motta |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9742090948110017 |
dc.contributor.referee2.fl_str_mv |
Dalboni, Maria Aparecida |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/9818040147487320 |
dc.contributor.referee3.fl_str_mv |
Custódio, Melani Ribeiro |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/3390801574622152 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6735100952659941 |
dc.contributor.author.fl_str_mv |
Carvalho, Luci Carla Dias Batista |
contributor_str_mv |
Elias, Rosilene Motta Elias, Rosilene Motta Dalboni, Maria Aparecida Custódio, Melani Ribeiro |
dc.subject.por.fl_str_mv |
doença renal crônica tomografia de crânio hipertensão arterial klotho |
topic |
doença renal crônica tomografia de crânio hipertensão arterial klotho chronic kidney disease skull tomography arterial hypertension klotho CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
chronic kidney disease skull tomography arterial hypertension klotho |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: In view of the increase in life expectancy and the prevalence of diabetes and arterial hypertension, an increase in the elderly population with chronic kidney disease (CKD) has been observed. Vascular calcification is frequent in elderly and in patients with CKD. Some experimental studies have been observed a relationship between Klotho and vascular calcification. Thus, it is possible that Klotho is a risk factor for vascular calcification in patients with CKD. This study proposes the assessment of the association between intracranial vessel calcification and serum Klotho. Methods: This is a subanalysis of CTs performed in a study evaluating the association between cognition with markers of mineral and bone metabolism. We evaluated 60 CTs of patients with stages 4 and 5 CKD not on dialysis. Clinical, biochemical, and demographic data were collected. The CT was reported in a structured way, following the same sequence in all patients. Only vascular but not parenchymal calcification was evaluated. Results: Patients aged 81 7 years (65% men, 93% with hypertension, and 48% with diabetes). The median Klotho concentration was 783 (610, 994) pg/ml. Vascular calcification was observed in 18 patients (30%). Patients with intracranial vascular calcification were not distinguished from those without calcification regarding sex, age, body mass index, blood pressure, albumin, creatinine, cholesterol, calcium, phosphorus, and fibroblast growth factor 23. They had a slightly lower percentage of hypertension (83.3 vs. 96.6%, p = 0.042), and a lower concentration of Klotho [613 (509 - 805) vs. 824 (704, 1042), p = 0.009]. This difference remained significant even after adjusting for age, renal function, and classical cardiovascular risk factors such as diabetes, blood pressure, and cholesterol. Conclusion: Patients with moderate to severe CKD present intracranial vascular calcification in association with lower Klotho concentration. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-12-17 |
dc.date.accessioned.fl_str_mv |
2022-07-21T15:20:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Carvalho, Luci Carla Dias Batista. Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho. 2020. 56 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/2991 |
identifier_str_mv |
Carvalho, Luci Carla Dias Batista. Calcificação vascular intracraniana em pacientes idosos com doença renal crônica: relação com klotho. 2020. 56 f. Dissertação( Programa de Mestrado em Medicina) - Universidade Nove de Julho, São Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/2991 |
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por |
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por |
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8765449414823306929 |
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Universidade Nove de Julho |
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Programa de Mestrado em Medicina |
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UNINOVE |
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Brasil |
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Saúde |
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Universidade Nove de Julho |
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