Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze

Detalhes bibliográficos
Autor(a) principal: Gomes,Flavia
Data de Publicação: 2010
Outros Autores: Greidinger,Marília, Salviano,Marcelo, Couto,Kalliu Carvalho, Scaperlli,Graziela Ferreira, Alves,Sérgio Henrique de Sousa, Cruz,Antonio Pedro de Mello
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Psychology & Neuroscience (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882010000200014
Resumo: This study investigated the behavioral effects in the forced swim test (FST) and the elevated plus-maze (EPM) of acute administration of WAY 161503 ([4aR]-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5[6 H]-one), a selective 5-HT2C receptor agonist with putative antidepressant-like properties. Fifteen minutes after intraperitoneal (i.p.) injections of either WAY 161503 (1, 3 and 10 mg/kg) or saline, naive male Wistar rats were exposed to the EPM for 5 min to assess classical and ethological anxiety-like measures. Immediately after EPM exposure, each animal was exposed to the FST, and the latency to the first episode of immobility was recorded (trial session). Twenty-four hours later, the rats were reexposed to a second EPM-FST exposure sequence (test session for FST) under the effect of the same pharmacological treatment. The two lowest WAY 161503 doses selectively reduced open-arm exploration and increased risk-assessment without affecting locomotor activity. This selective anxiogenic-like effect was observed in both the first and second EPM exposures. The highest WAY 161503 dose produced robust locomotor impairment. In the FST, the same WAY 161503 doses significantly increased the latency to the first immobility in the test session, a behavioral profile that suggests an antidepressant-like action. These results further support the involvement of 5-HT2C receptors in the mediation of anxiety and suggest an intricate relationship between anxiogenic- and antidepressant-like actions.
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spelling Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus mazeanxietydepressionserotonin5-HT2C receptor agonistWAY 161503animal modelsThis study investigated the behavioral effects in the forced swim test (FST) and the elevated plus-maze (EPM) of acute administration of WAY 161503 ([4aR]-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5[6 H]-one), a selective 5-HT2C receptor agonist with putative antidepressant-like properties. Fifteen minutes after intraperitoneal (i.p.) injections of either WAY 161503 (1, 3 and 10 mg/kg) or saline, naive male Wistar rats were exposed to the EPM for 5 min to assess classical and ethological anxiety-like measures. Immediately after EPM exposure, each animal was exposed to the FST, and the latency to the first episode of immobility was recorded (trial session). Twenty-four hours later, the rats were reexposed to a second EPM-FST exposure sequence (test session for FST) under the effect of the same pharmacological treatment. The two lowest WAY 161503 doses selectively reduced open-arm exploration and increased risk-assessment without affecting locomotor activity. This selective anxiogenic-like effect was observed in both the first and second EPM exposures. The highest WAY 161503 dose produced robust locomotor impairment. In the FST, the same WAY 161503 doses significantly increased the latency to the first immobility in the test session, a behavioral profile that suggests an antidepressant-like action. These results further support the involvement of 5-HT2C receptors in the mediation of anxiety and suggest an intricate relationship between anxiogenic- and antidepressant-like actions.Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882010000200014Psychology & Neuroscience v.3 n.2 2010reponame:Psychology & Neuroscience (Online)instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)instacron:PUCRJ10.3922/j.psns.2010.2.014info:eu-repo/semantics/openAccessGomes,FlaviaGreidinger,MaríliaSalviano,MarceloCouto,Kalliu CarvalhoScaperlli,Graziela FerreiraAlves,Sérgio Henrique de SousaCruz,Antonio Pedro de Melloeng2011-03-21T00:00:00Zoai:scielo:S1983-32882010000200014Revistahttps://www.apa.org/pubs/journals/pnePRIhttps://old.scielo.br/oai/scielo-oai.phppsycneuro@psycneuro.org1983-32881984-3054opendoar:2011-03-21T00:00Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)false
dc.title.none.fl_str_mv Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
title Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
spellingShingle Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
Gomes,Flavia
anxiety
depression
serotonin
5-HT2C receptor agonist
WAY 161503
animal models
title_short Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
title_full Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
title_fullStr Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
title_full_unstemmed Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
title_sort Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
author Gomes,Flavia
author_facet Gomes,Flavia
Greidinger,Marília
Salviano,Marcelo
Couto,Kalliu Carvalho
Scaperlli,Graziela Ferreira
Alves,Sérgio Henrique de Sousa
Cruz,Antonio Pedro de Mello
author_role author
author2 Greidinger,Marília
Salviano,Marcelo
Couto,Kalliu Carvalho
Scaperlli,Graziela Ferreira
Alves,Sérgio Henrique de Sousa
Cruz,Antonio Pedro de Mello
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes,Flavia
Greidinger,Marília
Salviano,Marcelo
Couto,Kalliu Carvalho
Scaperlli,Graziela Ferreira
Alves,Sérgio Henrique de Sousa
Cruz,Antonio Pedro de Mello
dc.subject.por.fl_str_mv anxiety
depression
serotonin
5-HT2C receptor agonist
WAY 161503
animal models
topic anxiety
depression
serotonin
5-HT2C receptor agonist
WAY 161503
animal models
description This study investigated the behavioral effects in the forced swim test (FST) and the elevated plus-maze (EPM) of acute administration of WAY 161503 ([4aR]-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5[6 H]-one), a selective 5-HT2C receptor agonist with putative antidepressant-like properties. Fifteen minutes after intraperitoneal (i.p.) injections of either WAY 161503 (1, 3 and 10 mg/kg) or saline, naive male Wistar rats were exposed to the EPM for 5 min to assess classical and ethological anxiety-like measures. Immediately after EPM exposure, each animal was exposed to the FST, and the latency to the first episode of immobility was recorded (trial session). Twenty-four hours later, the rats were reexposed to a second EPM-FST exposure sequence (test session for FST) under the effect of the same pharmacological treatment. The two lowest WAY 161503 doses selectively reduced open-arm exploration and increased risk-assessment without affecting locomotor activity. This selective anxiogenic-like effect was observed in both the first and second EPM exposures. The highest WAY 161503 dose produced robust locomotor impairment. In the FST, the same WAY 161503 doses significantly increased the latency to the first immobility in the test session, a behavioral profile that suggests an antidepressant-like action. These results further support the involvement of 5-HT2C receptors in the mediation of anxiety and suggest an intricate relationship between anxiogenic- and antidepressant-like actions.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882010000200014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882010000200014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3922/j.psns.2010.2.014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Pontificia Universidade Católica do Rio de Janeiro
Universidade de Brasília
Universidade de São Paulo
publisher.none.fl_str_mv Pontificia Universidade Católica do Rio de Janeiro
Universidade de Brasília
Universidade de São Paulo
dc.source.none.fl_str_mv Psychology & Neuroscience v.3 n.2 2010
reponame:Psychology & Neuroscience (Online)
instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)
instacron:PUCRJ
instname_str Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)
instacron_str PUCRJ
institution PUCRJ
reponame_str Psychology & Neuroscience (Online)
collection Psychology & Neuroscience (Online)
repository.name.fl_str_mv Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)
repository.mail.fl_str_mv psycneuro@psycneuro.org
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