Relationship between circulating testosterone and emotional behavior in rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Psychology & Neuroscience (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882012000100015 |
Resumo: | The experiment was aimed at investigating the relationship between reduced circulating/endogenous testosterone occasioned by orchiectomy and emotional behavior using the open field test. Eighteen male Wistar rats were randomly selected and classified into two groups: orchiectomized and nonorchiectomized. Orchiectomy was carried out by simple sham surgery. After recovery from orchiectomy, plasma testosterone was determined in both groups after which each animal was observed in the open-field for neurobehavioral activities. The result showed a significant (p <0.05) reduction in plasma testosterone concentration as well as the frequencies of novelty-induced neurobehaviors scored in the open field arena in the orchiectomized group when compared with the nonorchiectomized group. Results indicated that a reduction in circulating testosterone exerts behavioral deficits in orchiectomized animals in the form of fear imposed by exposure to a novel environment resulting in fewer activities. This observation was confirmed by the presence of testosterone receptors in specific brain areas associated with behavioral modulation. We therefore conclude that circulating testosterone could be one of the endogenous mechanisms responsible for coping with fear induced by exposure to a novel environment. |
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Psychology & Neuroscience (Online) |
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Relationship between circulating testosterone and emotional behavior in ratsorchiectomytestosteroneopen fieldfearneurobehavioramygdalaThe experiment was aimed at investigating the relationship between reduced circulating/endogenous testosterone occasioned by orchiectomy and emotional behavior using the open field test. Eighteen male Wistar rats were randomly selected and classified into two groups: orchiectomized and nonorchiectomized. Orchiectomy was carried out by simple sham surgery. After recovery from orchiectomy, plasma testosterone was determined in both groups after which each animal was observed in the open-field for neurobehavioral activities. The result showed a significant (p <0.05) reduction in plasma testosterone concentration as well as the frequencies of novelty-induced neurobehaviors scored in the open field arena in the orchiectomized group when compared with the nonorchiectomized group. Results indicated that a reduction in circulating testosterone exerts behavioral deficits in orchiectomized animals in the form of fear imposed by exposure to a novel environment resulting in fewer activities. This observation was confirmed by the presence of testosterone receptors in specific brain areas associated with behavioral modulation. We therefore conclude that circulating testosterone could be one of the endogenous mechanisms responsible for coping with fear induced by exposure to a novel environment.Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882012000100015Psychology & Neuroscience v.5 n.1 2012reponame:Psychology & Neuroscience (Online)instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)instacron:PUCRJ10.3922/j.psns.2012.1.15info:eu-repo/semantics/openAccessOyekunle,Olanrewaju AkinloyeIbironke,Goke FrancisOpabunmi,Oluwole Adebayoeng2012-10-26T00:00:00Zoai:scielo:S1983-32882012000100015Revistahttps://www.apa.org/pubs/journals/pnePRIhttps://old.scielo.br/oai/scielo-oai.phppsycneuro@psycneuro.org1983-32881984-3054opendoar:2012-10-26T00:00Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)false |
dc.title.none.fl_str_mv |
Relationship between circulating testosterone and emotional behavior in rats |
title |
Relationship between circulating testosterone and emotional behavior in rats |
spellingShingle |
Relationship between circulating testosterone and emotional behavior in rats Oyekunle,Olanrewaju Akinloye orchiectomy testosterone open field fear neurobehavior amygdala |
title_short |
Relationship between circulating testosterone and emotional behavior in rats |
title_full |
Relationship between circulating testosterone and emotional behavior in rats |
title_fullStr |
Relationship between circulating testosterone and emotional behavior in rats |
title_full_unstemmed |
Relationship between circulating testosterone and emotional behavior in rats |
title_sort |
Relationship between circulating testosterone and emotional behavior in rats |
author |
Oyekunle,Olanrewaju Akinloye |
author_facet |
Oyekunle,Olanrewaju Akinloye Ibironke,Goke Francis Opabunmi,Oluwole Adebayo |
author_role |
author |
author2 |
Ibironke,Goke Francis Opabunmi,Oluwole Adebayo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Oyekunle,Olanrewaju Akinloye Ibironke,Goke Francis Opabunmi,Oluwole Adebayo |
dc.subject.por.fl_str_mv |
orchiectomy testosterone open field fear neurobehavior amygdala |
topic |
orchiectomy testosterone open field fear neurobehavior amygdala |
description |
The experiment was aimed at investigating the relationship between reduced circulating/endogenous testosterone occasioned by orchiectomy and emotional behavior using the open field test. Eighteen male Wistar rats were randomly selected and classified into two groups: orchiectomized and nonorchiectomized. Orchiectomy was carried out by simple sham surgery. After recovery from orchiectomy, plasma testosterone was determined in both groups after which each animal was observed in the open-field for neurobehavioral activities. The result showed a significant (p <0.05) reduction in plasma testosterone concentration as well as the frequencies of novelty-induced neurobehaviors scored in the open field arena in the orchiectomized group when compared with the nonorchiectomized group. Results indicated that a reduction in circulating testosterone exerts behavioral deficits in orchiectomized animals in the form of fear imposed by exposure to a novel environment resulting in fewer activities. This observation was confirmed by the presence of testosterone receptors in specific brain areas associated with behavioral modulation. We therefore conclude that circulating testosterone could be one of the endogenous mechanisms responsible for coping with fear induced by exposure to a novel environment. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882012000100015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882012000100015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3922/j.psns.2012.1.15 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
dc.source.none.fl_str_mv |
Psychology & Neuroscience v.5 n.1 2012 reponame:Psychology & Neuroscience (Online) instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) instacron:PUCRJ |
instname_str |
Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
instacron_str |
PUCRJ |
institution |
PUCRJ |
reponame_str |
Psychology & Neuroscience (Online) |
collection |
Psychology & Neuroscience (Online) |
repository.name.fl_str_mv |
Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
repository.mail.fl_str_mv |
psycneuro@psycneuro.org |
_version_ |
1754821072837935104 |