Análise da factibilidade e segurança do transplante autólogo de células tronco de medula óssea em pacientes com epilepsia

• Autor(a) principal: Carrion, Maria Julia Machline
• Data de Publicação: 2010
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional PUCRS
• Texto Completo: http://hdl.handle.net/10923/4515
• topic: MEDICINA; TRANSPLANTE; CÉLULAS-TRONCO; EPILEPSIA

Temporal Lobe Epilepsy (TLE) is the most common convulsive presentation in adults and commonly presents as refractory to pharmacological treatment. Anatomical and physiological changes are often present in patients with TLE such as Hippocampal Atrophy seen in MRI studies. Stem cells are proven to have the ability of regenerating hipocampal structures in experimental models. The aim of this study is to evaluate safety and feasibility of bone marrow mononuclear stem cells (BMMSC) transplant for the treatment of patients with refractory TLE with unilateral hipocampal sclerosis. Nine TLE adult patients were studied, with diagnose confirmed by clinical history, MRI study and hippcocampal volumetry, prolonged video EEG for seizure recording and laboratory tests. After informed consent and fulfilling all criteria for side congruence patients underwent BMMSC transplant. The transplant was performed by selective posterior cerebral artery catheterism, transplanting from 1. 51 x 108 to 5. 51 x 108 mononuclear cells. No significative adverse effect was registered neither during procedure nor during follow up period. Three patients (44. 5%) remained at Engel Class IA, ) 04 patients at IB and 02 patients IIA. Given the results obtained, we conclude that BMMSC transplant seems to be feasible and safe so far in patients with refractory TLE. Seizure control achieved in this first population gives us a promising therapeutic potential in treatment of this population.