Funções executivas na epilepsia de lobo temporal associada à esclerose hipocampal: impacto da ressecção seletiva das estruturas mesiais temporais

• Autor(a) principal: Tisser, Luciana Alves
• Data de Publicação: 2007
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional PUCRS
• Texto Completo: http://hdl.handle.net/10923/4380
• topic: NEUROCIÊNCIA; EPILEPSIA DO LOBO TEMPORAL; ESCLEROSE; NEUROPSICOLOGIA

Purpose: To study the performance of patients with unilateral temporal lobe epilepsy due to hippocampal sclerosis (TLE/HS) in a neuropsychological test battery of executive functions before and after surgical resection of mesial temporal lobe structures to control seizures. Methods: Two studies were carried out. The first compared performance in a neuropsychological test battery of executive and memory functions, as well as in the scores of scales measuring anxiety and depression, of patients with TLE/HS and of a control group of people without neurological or psychiatric disorders matched for age, gender and level of education. In the second study, the performance and scores in the same batteies and scales were compared within the cohort of TLE/HS patients both before and six months after unilateral selective amygdalo-hippocampectomy. Results: Sixty-four % of the 25 patients with TLE/HS completed lass than four categories in the Wisconsin Card Sorting Test (WCST) and 40% had potentially significant abnormalities in the Stroop test. In all tests of executive function, patients had a significantly poorer performance than the controls, except for digit span in the reverse order. A significant improvement after surgery was observed in many subscores of the WCST, including total number of correct matchings, total number of errors, number of perseverative errors and of perseverative responses. Conclusions: Patients with unilateral TLE/HS have significant deficits in tests probing executive function when compared to a control group. Performance in this group significantly improves in many subscores of the WCST following selective resection of the epileptogenic mesial temporal structures.