Efeito da laserterapia (GaAlAs) no processo de reparo dos tecidos ósseo e mole em ratos submetidos à terapia com Zolendronato

• Autor(a) principal: Izquierdo, Cristina de Moraes
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional PUCRS
• Texto Completo: http://hdl.handle.net/10923/390
• topic: ODONTOLOGIA; CIRURGIA BUCOMAXILOFACIAL; CICATRIZAÇÃO (ODONTOLOGIA); LASER - ODONTOLOGIA; OSSOS - NECROSE

Bisphosphonates are drugs, administered/given either orally or intravenously, that are used to treat bone disorders. They inhibit osteoclast formation by suppressing osteoclast-mediated bone resorption and accumulate persistently in the mineralized bone matrix. Notwithstanding the benefit obtained from their use, treatment with bisphosphonates has been associated with maxillary bone necrosis. In this study, 54 rats were used. The rats were randomized into three different groups: G1 (control group); G2 (group treated with zoledronic acid) and G3 (group treated with zoledronic acid and laser therapy). Each group was divided in 2 subgroups (A and B). In group A, the incisive were extracted. In group B, a bur was used to remove bone from the first molar region.Zoledronic acid treatment was initiated one month before surgery and given in three doses of 0,6 mg/kg. Low-level laser therapy was applied during the procedure and every 48h, at a dose of 1J/cm2, given punctually, using a power of 90 mW and wavelength of λ=830nm. The rats were killed at 44 days after the surgical procedure. Specimens were evaluated macroscopically, and underwent histological and histomorphometric analysis. Statistical analysis included the Chi-Square test, Fisher´s Exact test and Anova test. The results indicated that laser therapy didn´t prevent the osteonecrosis. And that Zolendronic Acid associated with a local pathology has the potencial to increase the occurrence of osteonecrosis.