Hypolipidemic effect of camu-camu juice in rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9130 |
Resumo: | Objective This study evaluated the potential hypolipidemic effect of camu-camu juice (Myrciaria dubia (Kunth) McVaugh) in dyslipidemic rats. Methods Seventy-two adult male Wistar rats (Rattus norvegicus var. albinus Berkenhout) with an average weight of 200g were used. The experiment was divided into two phases: induction of dyslipidemia and treatment. Dyslipidemia was induced by a high-fat diet (commercial feed plus 10.0% lard, 1.0% cholesterol and 0.1% cholic acid) given to the animals for 21 days. In the treatment phase, 40 dyslipidemic rats were randomly divided into five groups (n=8). Of these, three were subjected to different treatments with camu-camu juice: 0.4mL.kg-1, 4.0mL.kg-1 and 10mL.kg-1 for 14 days. The other two groups were kept as parameters: a basal group (normolipidemic) and a hyperlipidemic group receiving 10mL.kg-1 of quercetin (standard treatment). The potential hypolipidemic effect of camu-camu juice was assessed by the following measurements: plasma lipoproteins (triacylglycerol, total cholesterol, high density lipoprotein-cholesterol and low density lipoproteincholesterol), fecal and liver cholesterol, and measurements of feed intake and body weight. Results All dosages of camu-camu juice were hypolipidemic, reducing triacylglycerol, total cholesterol, fecal cholesterol excretion and hepatic cholesterol. The best results were obtained by the 10 mL.kg-1 dosage of camu-camu juice. Rat body weight and food intake did not vary significantly during the treatment. Conclusion Camu-camu juice has a hypolipidemic effect in dyslipidemic rats. These results can be used as reference for future studies on this Amazonian fruit. |
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Hypolipidemic effect of camu-camu juice in ratsEfeito hipolipidêmico do suco de camu-camu em ratosDyslipidemiaQuercetinRatsDislipidemiasQuercetinaRatosObjective This study evaluated the potential hypolipidemic effect of camu-camu juice (Myrciaria dubia (Kunth) McVaugh) in dyslipidemic rats. Methods Seventy-two adult male Wistar rats (Rattus norvegicus var. albinus Berkenhout) with an average weight of 200g were used. The experiment was divided into two phases: induction of dyslipidemia and treatment. Dyslipidemia was induced by a high-fat diet (commercial feed plus 10.0% lard, 1.0% cholesterol and 0.1% cholic acid) given to the animals for 21 days. In the treatment phase, 40 dyslipidemic rats were randomly divided into five groups (n=8). Of these, three were subjected to different treatments with camu-camu juice: 0.4mL.kg-1, 4.0mL.kg-1 and 10mL.kg-1 for 14 days. The other two groups were kept as parameters: a basal group (normolipidemic) and a hyperlipidemic group receiving 10mL.kg-1 of quercetin (standard treatment). The potential hypolipidemic effect of camu-camu juice was assessed by the following measurements: plasma lipoproteins (triacylglycerol, total cholesterol, high density lipoprotein-cholesterol and low density lipoproteincholesterol), fecal and liver cholesterol, and measurements of feed intake and body weight. Results All dosages of camu-camu juice were hypolipidemic, reducing triacylglycerol, total cholesterol, fecal cholesterol excretion and hepatic cholesterol. The best results were obtained by the 10 mL.kg-1 dosage of camu-camu juice. Rat body weight and food intake did not vary significantly during the treatment. Conclusion Camu-camu juice has a hypolipidemic effect in dyslipidemic rats. These results can be used as reference for future studies on this Amazonian fruit.Objetivo Este estudo teve como objetivo avaliar o potencial hipolipidêmico do suco de camu-camu (Myrciaria dúbia (Kunth) McVaugh) em ratos dislipidêmicos. Métodos Foram utilizados 72 ratos (Rattus norvegicus var. albinus) machos adultos da linhagem Wistar, com peso médio de 200g. O experimento foi dividido em duas fases: indução da dislipidemia e tratamento. Para indução da dislipidemia, todos os ratos receberam ração hiperlipídica (ração comercial adicionada a 10,0% de banha suína, 1,0% colesterol e 0,1% de ácido cólico) durante 21 dias. Na fase de tratamento, 40 ratos dislipidêmicos foram divididos aleatoriamente em 5 grupos (n=8), sendo 3 deles submetidos a tratamento com diferentes concentrações de suco de camu-camu (0,4mL.kg-1, 4,0mL.kg-1 e 10mL.kg-1) por 14 dias, 1 grupo submetido a tratamento com quercetina (10mL.kg-1) e 1 grupo hiperlidêmico. Estes dois últimos foram mantidos como parâmetro, ao lado do grupo basal. Para avaliar o efeito modulador do suco de camu-camu no perfil lipídico dos ratos, foram verificadas as concentrações de triacilgliceróis, colesterol total, lipoproteína de alta intensidade e lipoproteína de baixa intensidade, no plasma, assim como os níveis de colesterol fecal e hepático. Também foram observados o controle da ingestão de ração e a avaliação da massa corporal. Resultados As diferentes doses de suco de camu-camu e de quercetina apresentaram efeitos moduladores do perfil lipídico, nou seja, redução de triacilgliceróis, colesterol total, excreção fecal de colesterol, bem como redução do colesterol hepático. Salienta-se que os melhores resultados foram obtidos com a concentração de 10mL.kg-1. Em relação à massa corporal, os ratos que receberam essa concentração de suco de camu e quercetina mantiveram peso significativamente inferior ao obervado nos demais tratamentos, tanto no início quanto ao final da intervenção. Resultado similar foi observado quanto ao consumo de ração. Conclusão O suco de camu-camu apresentou efeito modulador do perfil lipídico em ratos dislipidêmicos. Os resultados poderão ser utilizados como referência em futuros trabalhos acerca desse fruto amazônico.Núcleo de Editoração – PUC-Campinas2023-08-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9130Brazilian Journal of Nutrition; Vol. 25 No. 1 (2012): Revista de NutriçãoRevista de Nutrição; Vol. 25 Núm. 1 (2012): Revista de NutriçãoRevista de Nutrição; v. 25 n. 1 (2012): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9130/6516Copyright (c) 2023 Maíra Cássia SCHWERTZ, Jeniffer Resende Patrocínio MAIA, Risonilce Fernandes Silva de SOUSA, Jaime Paiva Lopes AGUIAR, Lucia Kiyoko Ozaki YUYAMAhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSCHWERTZ, Maíra CássiaMAIA, Jeniffer Resende PatrocínioSOUSA, Risonilce Fernandes Silva deAGUIAR, Jaime Paiva Lopes YUYAMA, Lucia Kiyoko Ozaki2023-11-30T12:43:14Zoai:ojs.periodicos.puc-campinas.edu.br:article/9130Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-11-30T12:43:14Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Hypolipidemic effect of camu-camu juice in rats Efeito hipolipidêmico do suco de camu-camu em ratos |
title |
Hypolipidemic effect of camu-camu juice in rats |
spellingShingle |
Hypolipidemic effect of camu-camu juice in rats SCHWERTZ, Maíra Cássia Dyslipidemia Quercetin Rats Dislipidemias Quercetina Ratos |
title_short |
Hypolipidemic effect of camu-camu juice in rats |
title_full |
Hypolipidemic effect of camu-camu juice in rats |
title_fullStr |
Hypolipidemic effect of camu-camu juice in rats |
title_full_unstemmed |
Hypolipidemic effect of camu-camu juice in rats |
title_sort |
Hypolipidemic effect of camu-camu juice in rats |
author |
SCHWERTZ, Maíra Cássia |
author_facet |
SCHWERTZ, Maíra Cássia MAIA, Jeniffer Resende Patrocínio SOUSA, Risonilce Fernandes Silva de AGUIAR, Jaime Paiva Lopes YUYAMA, Lucia Kiyoko Ozaki |
author_role |
author |
author2 |
MAIA, Jeniffer Resende Patrocínio SOUSA, Risonilce Fernandes Silva de AGUIAR, Jaime Paiva Lopes YUYAMA, Lucia Kiyoko Ozaki |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
SCHWERTZ, Maíra Cássia MAIA, Jeniffer Resende Patrocínio SOUSA, Risonilce Fernandes Silva de AGUIAR, Jaime Paiva Lopes YUYAMA, Lucia Kiyoko Ozaki |
dc.subject.por.fl_str_mv |
Dyslipidemia Quercetin Rats Dislipidemias Quercetina Ratos |
topic |
Dyslipidemia Quercetin Rats Dislipidemias Quercetina Ratos |
description |
Objective This study evaluated the potential hypolipidemic effect of camu-camu juice (Myrciaria dubia (Kunth) McVaugh) in dyslipidemic rats. Methods Seventy-two adult male Wistar rats (Rattus norvegicus var. albinus Berkenhout) with an average weight of 200g were used. The experiment was divided into two phases: induction of dyslipidemia and treatment. Dyslipidemia was induced by a high-fat diet (commercial feed plus 10.0% lard, 1.0% cholesterol and 0.1% cholic acid) given to the animals for 21 days. In the treatment phase, 40 dyslipidemic rats were randomly divided into five groups (n=8). Of these, three were subjected to different treatments with camu-camu juice: 0.4mL.kg-1, 4.0mL.kg-1 and 10mL.kg-1 for 14 days. The other two groups were kept as parameters: a basal group (normolipidemic) and a hyperlipidemic group receiving 10mL.kg-1 of quercetin (standard treatment). The potential hypolipidemic effect of camu-camu juice was assessed by the following measurements: plasma lipoproteins (triacylglycerol, total cholesterol, high density lipoprotein-cholesterol and low density lipoproteincholesterol), fecal and liver cholesterol, and measurements of feed intake and body weight. Results All dosages of camu-camu juice were hypolipidemic, reducing triacylglycerol, total cholesterol, fecal cholesterol excretion and hepatic cholesterol. The best results were obtained by the 10 mL.kg-1 dosage of camu-camu juice. Rat body weight and food intake did not vary significantly during the treatment. Conclusion Camu-camu juice has a hypolipidemic effect in dyslipidemic rats. These results can be used as reference for future studies on this Amazonian fruit. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9130 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9130 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9130/6516 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 25 No. 1 (2012): Revista de Nutrição Revista de Nutrição; Vol. 25 Núm. 1 (2012): Revista de Nutrição Revista de Nutrição; v. 25 n. 1 (2012): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
_version_ |
1799126071856070656 |