Transgenic and conventional Brazilian soybeans don’t cause or prevent preneoplastic colon lesions or oxidative stress in a 90-day in vivo study

• Autor(a) principal: SBRUZZI, Felipe Augusto
• Data de Publicação: 2023
• Outros Autores: VENÂNCIO, Vinícius de Paula, Costa RESCK, Maria Cristina, Ribeiro Pereira Lima BRIGAGÃO, Maísa, AZEVEDO, Luciana
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/8509
• topic: Aberrant crypt foci; Colon carcinogenesis; Dimethlyhydrazine; Free radicals; Genetically Modified Organisms; Transgenic soybean; Focos de criptas aberrantes; Carcinogênese de cólon; Dimetilhidrazina; Radicais livres; Organismo genéticamente modificados; Soja transgênica

ObjectiveThe study presents the results of a 90-day safety assessment of rats fed with four varieties of soybeans, BRS 245 RR and BRS Valiosa RR (transgenic), BRS 133 and MG BR46 Conquista (non-transgenic). MethodsDiets were prepared by incorporating toasted soybean flour to a commercial diet at 1%, 10% or 20% weight In the in vivo experimental the rats’ body weight, body weight gain, food consumption, number of aberrant crypt foci, oxidative stress biomarkers, urea and creatinine levels were analyzed and compared between experimental groups, as well as histopathological observations (digestive tract, liver, kidneys). ResultsThe results indicate that glyphosate-tolerant soy varieties neither induce nor prevent aberrant crypt foci induction, nor do their conventional counterparts. Similarly, none of the four soybean varieties tested induced changes in the digestive tract, liver or kidney. Serum biochemical parameters were also unchanged. ConclusionThe consumption of both, conventional and transgenic soybeans, were insufficient to ameliorate dimethylhydrazine-induced oxidative stress.