Antioxidant supplementation: focusing on burned patients

Detalhes bibliográficos
Autor(a) principal: BARBOSA, Eliana
Data de Publicação: 2023
Outros Autores: Machado MOREIRA, Emília Addison, FAINTUCH, Joel, Lopes PEREIMA, Maurício José
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9723
Resumo: In burn injuries, free radicals are produced during fluid replacement, altering multiple components of the organism such as nucleic acids, lipids and proteins. Thus, if on the one hand restoring blood flow is generally necessary to recover normal cell function, on the other hand oxygen reperfusion into ischemic tissues triggers massive production of oxygen free radicals, therefore further exacerbating ischemic injury. The role of neutrophiles activated in the cell after burns has also received special attention. By means of the NADPH-oxidase system, adherent neutrophiles may release superoxide radicals inflicting major tissue damage. The burn injury not only increases the production of free radicals but it is also capable of impairing the antioxidant defense mechanism, subjecting the burned patient to oxidative stress, which can be a perpetuating factor of the inflammatory response and lead to progressive metabolic deterioration. Therefore, the purpose of this work is to provide updated information on antioxidant supplementation in burned patients and describe the benefits of this intervention.
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spelling Antioxidant supplementation: focusing on burned patientsSuplementação de antioxidantes: enfoque em queimadosantioxidantsoxidative stressburnsfree radicalsantioxidantesestresse oxidativoqueimadurasradicais livresIn burn injuries, free radicals are produced during fluid replacement, altering multiple components of the organism such as nucleic acids, lipids and proteins. Thus, if on the one hand restoring blood flow is generally necessary to recover normal cell function, on the other hand oxygen reperfusion into ischemic tissues triggers massive production of oxygen free radicals, therefore further exacerbating ischemic injury. The role of neutrophiles activated in the cell after burns has also received special attention. By means of the NADPH-oxidase system, adherent neutrophiles may release superoxide radicals inflicting major tissue damage. The burn injury not only increases the production of free radicals but it is also capable of impairing the antioxidant defense mechanism, subjecting the burned patient to oxidative stress, which can be a perpetuating factor of the inflammatory response and lead to progressive metabolic deterioration. Therefore, the purpose of this work is to provide updated information on antioxidant supplementation in burned patients and describe the benefits of this intervention.Na queimadura, os radicais livres são produzidos durante a reposição de fluídos, alterando numerosos componentes, como os ácidos nucléicos, os lipídios e as proteínas. Sendo assim, se, por um lado, essa restauração do fluxo sanguíneo é, em geral, necessária para recuperar a função celular normal, por outro lado a reintrodução do sangue oxigenado nos tecidos isquêmicos contribui para uma produção excessiva de radicais livres derivados do oxigênio, exacerbando a lesão mediada pela isquemia. O papel dos neutrófilos ativados na célula após a queimadura também tem recebido atenção especial. A partir do sistema NADPH oxidase os neutrófilos aderidos podem produzir uma explosão de radical superóxido, produzindo um dano tecidual importante. A queimadura, além de aumentar a produção de radicais livres, também é capaz de impedir os mecanismos de defesa antioxidante, submetendo o paciente queimado ao estresse oxidativo, o qual se constitui em fator perpetuante da resposta inflamatória sistêmica, levando à piora progressiva do estado metabólico. Com esses dados, objetiva-se revisar os principais estudos com a suplementação de antioxidantes em pacientes críticos, com ênfase em pacientes queimados, e descrever os possíveis benefícios dessa intervenção.Núcleo de Editoração – PUC-Campinas2023-09-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9723Brazilian Journal of Nutrition; Vol. 20 No. 6 (2007): Revista de NutriçãoRevista de Nutrição; Vol. 20 Núm. 6 (2007): Revista de NutriçãoRevista de Nutrição; v. 20 n. 6 (2007): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9723/7069Copyright (c) 2023 Eliana BARBOSA, Emília Addison Machado MOREIRA, Joel FAINTUCH, Maurício José Lopes PEREIMAhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess BARBOSA, ElianaMachado MOREIRA, Emília Addison FAINTUCH, Joel Lopes PEREIMA, Maurício José2023-10-05T18:43:45Zoai:ojs.periodicos.puc-campinas.edu.br:article/9723Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-10-05T18:43:45Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Antioxidant supplementation: focusing on burned patients
Suplementação de antioxidantes: enfoque em queimados
title Antioxidant supplementation: focusing on burned patients
spellingShingle Antioxidant supplementation: focusing on burned patients
BARBOSA, Eliana
antioxidants
oxidative stress
burns
free radicals
antioxidantes
estresse oxidativo
queimaduras
radicais livres
title_short Antioxidant supplementation: focusing on burned patients
title_full Antioxidant supplementation: focusing on burned patients
title_fullStr Antioxidant supplementation: focusing on burned patients
title_full_unstemmed Antioxidant supplementation: focusing on burned patients
title_sort Antioxidant supplementation: focusing on burned patients
author BARBOSA, Eliana
author_facet BARBOSA, Eliana
Machado MOREIRA, Emília Addison
FAINTUCH, Joel
Lopes PEREIMA, Maurício José
author_role author
author2 Machado MOREIRA, Emília Addison
FAINTUCH, Joel
Lopes PEREIMA, Maurício José
author2_role author
author
author
dc.contributor.author.fl_str_mv BARBOSA, Eliana
Machado MOREIRA, Emília Addison
FAINTUCH, Joel
Lopes PEREIMA, Maurício José
dc.subject.por.fl_str_mv antioxidants
oxidative stress
burns
free radicals
antioxidantes
estresse oxidativo
queimaduras
radicais livres
topic antioxidants
oxidative stress
burns
free radicals
antioxidantes
estresse oxidativo
queimaduras
radicais livres
description In burn injuries, free radicals are produced during fluid replacement, altering multiple components of the organism such as nucleic acids, lipids and proteins. Thus, if on the one hand restoring blood flow is generally necessary to recover normal cell function, on the other hand oxygen reperfusion into ischemic tissues triggers massive production of oxygen free radicals, therefore further exacerbating ischemic injury. The role of neutrophiles activated in the cell after burns has also received special attention. By means of the NADPH-oxidase system, adherent neutrophiles may release superoxide radicals inflicting major tissue damage. The burn injury not only increases the production of free radicals but it is also capable of impairing the antioxidant defense mechanism, subjecting the burned patient to oxidative stress, which can be a perpetuating factor of the inflammatory response and lead to progressive metabolic deterioration. Therefore, the purpose of this work is to provide updated information on antioxidant supplementation in burned patients and describe the benefits of this intervention.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9723
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9723
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9723/7069
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 20 No. 6 (2007): Revista de Nutrição
Revista de Nutrição; Vol. 20 Núm. 6 (2007): Revista de Nutrição
Revista de Nutrição; v. 20 n. 6 (2007): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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