Early protein malnutrition impairs social memory in adult rats

Detalhes bibliográficos
Autor(a) principal: Consiglio da SILVA, Viviane
Data de Publicação: 2023
Outros Autores: de Sousa ALMEIDA, Sebastião
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9781
Resumo: ObjectiveThe objective of the present study was to investigate the effects of early protein malnutrition on the socialmemory of adult rats (Rattus norvegicus) using an experimental procedure. MethodsThe animals received isocaloric diets containing 6% or 16% of protein during the lactation phase (0-21 daysof age) and a commercial lab chow as from 22 days of age. The social memory test consisted of, after 2 dailyhabituation sessions (7minutes/session), to introduce an adult rat (100-114 days of age) and a young rat(30-44 days of age) into an acrylic cage (90cm.x.90cm.x.45cm), for two sessions separated by intervals of 30(Experiment 1) or 15 (Experiment 2) minutes. Social contact was defined as exploration/sniffing the anogenitalregion of the rat. The difference in the time spent in social contact between the first and second sessions wasdefined as the memory index. ResultsNo differences were observed in Experiment 1 due to the diet conditions. In Experiment 2, social contactdecreased from the first to the second session in the controls (p<0.05) in contrast to the malnourishedanimals, who showed no differences. ConclusionThese results suggest that early protein malnutrition impairs the social memory in adult rats.
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spelling Early protein malnutrition impairs social memory in adult ratsDesnutrição protéica no início da vida prejudica memória social em ratos adultosprotein malnutritionsocial behaviorratsdesnutrição protéicacomportamento socialratosObjectiveThe objective of the present study was to investigate the effects of early protein malnutrition on the socialmemory of adult rats (Rattus norvegicus) using an experimental procedure. MethodsThe animals received isocaloric diets containing 6% or 16% of protein during the lactation phase (0-21 daysof age) and a commercial lab chow as from 22 days of age. The social memory test consisted of, after 2 dailyhabituation sessions (7minutes/session), to introduce an adult rat (100-114 days of age) and a young rat(30-44 days of age) into an acrylic cage (90cm.x.90cm.x.45cm), for two sessions separated by intervals of 30(Experiment 1) or 15 (Experiment 2) minutes. Social contact was defined as exploration/sniffing the anogenitalregion of the rat. The difference in the time spent in social contact between the first and second sessions wasdefined as the memory index. ResultsNo differences were observed in Experiment 1 due to the diet conditions. In Experiment 2, social contactdecreased from the first to the second session in the controls (p<0.05) in contrast to the malnourishedanimals, who showed no differences. ConclusionThese results suggest that early protein malnutrition impairs the social memory in adult rats.ObjetivoAvaliar se a desnutrição protéica imposta no início da vida produz prejuízos em um procedimento experimental de memória social em ratos (Rattus norvegicus). MétodosOs animais receberam dietas isocalóricas contendo 6% ou 16% de proteína do nascimento aos 21 dias, e dieta comercial a partir de 22 dias de idade. O teste de memória social consistiu em, após duas sessões de habituação (7 minutos/sessão), introduzir um animal adulto (100-114 dias de idade) e um outro jovem (30-44 dias de idade) em uma arena de acrílico (90cm x 90cm x 45cm) em duas sessões separadas por intervalos de 30 (experimento 1) ou 15 minutos (experimento 2). O contato social foi definido como investigação (ato de cheirar/inspecionar a região anogenital). A diferença no tempo de contato entre a primeira e a segunda exposição é considerada um índice de memória social. ResultadosNenhuma diferença devida à dieta foi observada no experimento 1. No experimento 2 houve redução no tempo de contato social dos animais-controle da primeira para a segunda exposição (p<0,05) e não houve alteração nos animais desnutridos. ConclusãoEsses resultados sugerem que a desnutrição protéica precoce prejudica a memória social de ratos adultos.Núcleo de Editoração – PUC-Campinas2023-09-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9781Brazilian Journal of Nutrition; Vol. 19 No. 2 (2006): Revista de NutriçãoRevista de Nutrição; Vol. 19 Núm. 2 (2006): Revista de NutriçãoRevista de Nutrição; v. 19 n. 2 (2006): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9781/7121Copyright (c) 2023 Viviane Consiglio da SILVA, Sebastião de Sousa ALMEIDAhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessConsiglio da SILVA, Viviane de Sousa ALMEIDA, Sebastião 2023-09-19T19:20:47Zoai:ojs.periodicos.puc-campinas.edu.br:article/9781Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-09-19T19:20:47Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Early protein malnutrition impairs social memory in adult rats
Desnutrição protéica no início da vida prejudica memória social em ratos adultos
title Early protein malnutrition impairs social memory in adult rats
spellingShingle Early protein malnutrition impairs social memory in adult rats
Consiglio da SILVA, Viviane
protein malnutrition
social behavior
rats
desnutrição protéica
comportamento social
ratos
title_short Early protein malnutrition impairs social memory in adult rats
title_full Early protein malnutrition impairs social memory in adult rats
title_fullStr Early protein malnutrition impairs social memory in adult rats
title_full_unstemmed Early protein malnutrition impairs social memory in adult rats
title_sort Early protein malnutrition impairs social memory in adult rats
author Consiglio da SILVA, Viviane
author_facet Consiglio da SILVA, Viviane
de Sousa ALMEIDA, Sebastião
author_role author
author2 de Sousa ALMEIDA, Sebastião
author2_role author
dc.contributor.author.fl_str_mv Consiglio da SILVA, Viviane
de Sousa ALMEIDA, Sebastião
dc.subject.por.fl_str_mv protein malnutrition
social behavior
rats
desnutrição protéica
comportamento social
ratos
topic protein malnutrition
social behavior
rats
desnutrição protéica
comportamento social
ratos
description ObjectiveThe objective of the present study was to investigate the effects of early protein malnutrition on the socialmemory of adult rats (Rattus norvegicus) using an experimental procedure. MethodsThe animals received isocaloric diets containing 6% or 16% of protein during the lactation phase (0-21 daysof age) and a commercial lab chow as from 22 days of age. The social memory test consisted of, after 2 dailyhabituation sessions (7minutes/session), to introduce an adult rat (100-114 days of age) and a young rat(30-44 days of age) into an acrylic cage (90cm.x.90cm.x.45cm), for two sessions separated by intervals of 30(Experiment 1) or 15 (Experiment 2) minutes. Social contact was defined as exploration/sniffing the anogenitalregion of the rat. The difference in the time spent in social contact between the first and second sessions wasdefined as the memory index. ResultsNo differences were observed in Experiment 1 due to the diet conditions. In Experiment 2, social contactdecreased from the first to the second session in the controls (p<0.05) in contrast to the malnourishedanimals, who showed no differences. ConclusionThese results suggest that early protein malnutrition impairs the social memory in adult rats.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9781
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9781
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9781/7121
dc.rights.driver.fl_str_mv Copyright (c) 2023 Viviane Consiglio da SILVA, Sebastião de Sousa ALMEIDA
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Viviane Consiglio da SILVA, Sebastião de Sousa ALMEIDA
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 19 No. 2 (2006): Revista de Nutrição
Revista de Nutrição; Vol. 19 Núm. 2 (2006): Revista de Nutrição
Revista de Nutrição; v. 19 n. 2 (2006): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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