Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9602 |
Resumo: | ObjectiveThe objective of this study was to evaluate response to daily supplementation with iron bis-glycinate chelate and its impact on linear growth. MethodsA prospective study was done with 790 children aging from 6 to 36 months who attended daycare in São Paulo from 1999 to 2003. Hemoglobin levels, body weight and height/length were determined at the beginning and end of the study. Liquid iron bis-glycinate chelate was administered in a dosage of 5mg of elemental iron/kg of body weight/day given by the health provider of the daycare facility for a period of 12 weeks. ResultsSupplementation resulted in a significant, positive effect on the hemoglobin levels of 85.3% of the children with a mean increase of 1.6g/dL (p<0.001). In children aging from 25 to 36 months and in those with lower hemoglobin levels at the beginning of supplementation, there was a significantly higher increase. No gastrointestinal problem or intolerance to the supplement was observed during the intervention period. Supplementation also had an impact on growth and on the height-for-age indicator (z-score) in children older than 12 months but there was no impact on weight and on the weight-for-height and weight-for-age indicators. ConclusionThe results show that iron bis-glycinate chelate is an adequate supplement to treat iron deficiency anemia in young children since it is very well tolerated and promotes growth in children older than 12 months. |
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Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young childrenTratamento da anemia ferropriva com ferro quelato glicinato e crescimento de crianças na primeira infânciaIron chelating agentsAnemia iron deficiencyGrowthChild preschoolAgentes quelantes de ferroAnemia ferroprivaCrescimentoPré-escolarObjectiveThe objective of this study was to evaluate response to daily supplementation with iron bis-glycinate chelate and its impact on linear growth. MethodsA prospective study was done with 790 children aging from 6 to 36 months who attended daycare in São Paulo from 1999 to 2003. Hemoglobin levels, body weight and height/length were determined at the beginning and end of the study. Liquid iron bis-glycinate chelate was administered in a dosage of 5mg of elemental iron/kg of body weight/day given by the health provider of the daycare facility for a period of 12 weeks. ResultsSupplementation resulted in a significant, positive effect on the hemoglobin levels of 85.3% of the children with a mean increase of 1.6g/dL (p<0.001). In children aging from 25 to 36 months and in those with lower hemoglobin levels at the beginning of supplementation, there was a significantly higher increase. No gastrointestinal problem or intolerance to the supplement was observed during the intervention period. Supplementation also had an impact on growth and on the height-for-age indicator (z-score) in children older than 12 months but there was no impact on weight and on the weight-for-height and weight-for-age indicators. ConclusionThe results show that iron bis-glycinate chelate is an adequate supplement to treat iron deficiency anemia in young children since it is very well tolerated and promotes growth in children older than 12 months. ObjetivoAvaliar a resposta à suplementação diária com ferro quelato glicinato e seu impacto sobre o crescimento linear. MétodosRealizou-se um estudo prospectivo com 790 crianças, de 6 a 36 meses, que freqüentavam creches municipais de São Paulo no período de 1999 a 2003. Ao início e ao final do estudo a hemoglobina, o peso corporal e a estatura/comprimento foram coletados. Utilizou-se suplemento contendo ferro quelato glicinato em gotas na dose de 5mg Fe elementar/kg peso/dia, administrado na própria instituição pelo profissional de saúde da creche, por um período de 12 semanas. ResultadosA suplementação resultou em um significante e positivo efeito sobre os níveis de hemoglobina. A resposta ao tratamento foi positiva em 85,3% das crianças, com um aumento médio de 1,6g/dL nos valores de hemoglobina (p<0,001). Nas crianças de 25-36 meses e naquelas com valores de hemoglobina mais baixas ao início da suplementação, observou-se ganho significantemente maior. Durante o período de intervenção não foi observada nenhuma intercorrência gastrintestinal ou intolerância ao suplemento. Verificou-se também impacto sobre o ganho de estatura e o indicador nutricional estatura/idade (escore-Z) nas crianças com idade acima de 12 meses, porém o mesmo não foi observado em relação ao peso e aos indicadores peso/estatura e peso/idade. ConclusãoOs resultados indicam que o ferro quelato glicinato é um suplemento adequado para tratamento da anemia ferropriva em crianças na primeira infância, pela sua excelente tolerabilidade contribuindo também para o ganho de estatura entre crianças acima de 12 meses. Núcleo de Editoração – PUC-Campinas2023-09-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9602Brazilian Journal of Nutrition; Vol. 21 No. 5 (2008): Revista de NutriçãoRevista de Nutrição; Vol. 21 Núm. 5 (2008): Revista de NutriçãoRevista de Nutrição; v. 21 n. 5 (2008): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9602/6957Copyright (c) 2023 Luciana Cisoto RIBEIRO, Dirce Maria SIGULEMhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Cisoto RIBEIRO, Luciana SIGULEM, Dirce Maria2023-09-04T19:20:45Zoai:ojs.periodicos.puc-campinas.edu.br:article/9602Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-09-04T19:20:45Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children Tratamento da anemia ferropriva com ferro quelato glicinato e crescimento de crianças na primeira infância |
title |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children |
spellingShingle |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children Cisoto RIBEIRO, Luciana Iron chelating agents Anemia iron deficiency Growth Child preschool Agentes quelantes de ferro Anemia ferropriva Crescimento Pré-escolar |
title_short |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children |
title_full |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children |
title_fullStr |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children |
title_full_unstemmed |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children |
title_sort |
Treatment of iron deficiency anemia with iron bis-glycinate chelate and growth of young children |
author |
Cisoto RIBEIRO, Luciana |
author_facet |
Cisoto RIBEIRO, Luciana SIGULEM, Dirce Maria |
author_role |
author |
author2 |
SIGULEM, Dirce Maria |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Cisoto RIBEIRO, Luciana SIGULEM, Dirce Maria |
dc.subject.por.fl_str_mv |
Iron chelating agents Anemia iron deficiency Growth Child preschool Agentes quelantes de ferro Anemia ferropriva Crescimento Pré-escolar |
topic |
Iron chelating agents Anemia iron deficiency Growth Child preschool Agentes quelantes de ferro Anemia ferropriva Crescimento Pré-escolar |
description |
ObjectiveThe objective of this study was to evaluate response to daily supplementation with iron bis-glycinate chelate and its impact on linear growth. MethodsA prospective study was done with 790 children aging from 6 to 36 months who attended daycare in São Paulo from 1999 to 2003. Hemoglobin levels, body weight and height/length were determined at the beginning and end of the study. Liquid iron bis-glycinate chelate was administered in a dosage of 5mg of elemental iron/kg of body weight/day given by the health provider of the daycare facility for a period of 12 weeks. ResultsSupplementation resulted in a significant, positive effect on the hemoglobin levels of 85.3% of the children with a mean increase of 1.6g/dL (p<0.001). In children aging from 25 to 36 months and in those with lower hemoglobin levels at the beginning of supplementation, there was a significantly higher increase. No gastrointestinal problem or intolerance to the supplement was observed during the intervention period. Supplementation also had an impact on growth and on the height-for-age indicator (z-score) in children older than 12 months but there was no impact on weight and on the weight-for-height and weight-for-age indicators. ConclusionThe results show that iron bis-glycinate chelate is an adequate supplement to treat iron deficiency anemia in young children since it is very well tolerated and promotes growth in children older than 12 months. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9602 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9602 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9602/6957 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Luciana Cisoto RIBEIRO, Dirce Maria SIGULEM https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Luciana Cisoto RIBEIRO, Dirce Maria SIGULEM https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 21 No. 5 (2008): Revista de Nutrição Revista de Nutrição; Vol. 21 Núm. 5 (2008): Revista de Nutrição Revista de Nutrição; v. 21 n. 5 (2008): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
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1799126074292961280 |