Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9281 |
Resumo: | ObjectiveA -30G>A single nucleotide polymorphism in the promoter region of the glucokinase gene has been previously associated with obesity, insulin resistance and diabetes. The present study aimed to evaluate the association of this polymorphism with obesity and its comorbidities in a population from Northeast Iran. MethodsFive hundred and forty-two subjects aged 18 to 65 years were included in the study and divided into normal (BMI<25, n=220), overweight (25<BMI<30, n=135) and obese (BMI>30, n=187) groups. All subjects were genotyped for the -30G>A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism technique. ResultsThe genotypes and allele frequencies of the three groups did not differ significantly (p>0.05). When the study population was categorized according to diabetes mellitus, hyperlipidemia, hypertension and metabolic syndrome status, no significant difference in -30G>A genotypes and alleles was found between the subgroups with and without these disorders (p>0.05), apart from a significantly higher frequency of the G allele in the hyperlipidemic vs. non-hyperlipidemic subgroup (p<0.05). ConclusionThe findings of the present study do not support an association between the -30G>A polymorphism and high body mass index in the Iranian population. |
id |
PUC_CAMP-2_3c92228eb89313dcac03455c7cc88b6c |
---|---|
oai_identifier_str |
oai:ojs.periodicos.puc-campinas.edu.br:article/9281 |
network_acronym_str |
PUC_CAMP-2 |
network_name_str |
Revista de Nutrição |
repository_id_str |
|
spelling |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospitalPolimorfismo -30GBody mass indexGlucokinaseMetabolic syndromeObesitySingle nucleotide polymorphismÍndice de massa corporalGlucoquinaseSíndrome metabólicaObesidadePolimorfismo de nucleotídeo únicoObjectiveA -30G>A single nucleotide polymorphism in the promoter region of the glucokinase gene has been previously associated with obesity, insulin resistance and diabetes. The present study aimed to evaluate the association of this polymorphism with obesity and its comorbidities in a population from Northeast Iran. MethodsFive hundred and forty-two subjects aged 18 to 65 years were included in the study and divided into normal (BMI<25, n=220), overweight (25<BMI<30, n=135) and obese (BMI>30, n=187) groups. All subjects were genotyped for the -30G>A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism technique. ResultsThe genotypes and allele frequencies of the three groups did not differ significantly (p>0.05). When the study population was categorized according to diabetes mellitus, hyperlipidemia, hypertension and metabolic syndrome status, no significant difference in -30G>A genotypes and alleles was found between the subgroups with and without these disorders (p>0.05), apart from a significantly higher frequency of the G allele in the hyperlipidemic vs. non-hyperlipidemic subgroup (p<0.05). ConclusionThe findings of the present study do not support an association between the -30G>A polymorphism and high body mass index in the Iranian population.ObjetivoO polimorfismo de nucleotídeo único -30G>A, na região promotora do gene da glucoquinase, já foi associado à obesidade, resistência insulínica e diabete. O objetivo deste estudo foi avaliar a associação deste polimorfismo com a obesidade e suas comorbidades em uma população do nordeste iraniano. MétodosQuinhentos e quarenta e dois indivíduos com idades entre 18 e 65 anos foram divididos em três grupos: normal (BMI<25, n=220), sobrepeso (25<BMI<30, n=135) e obeso (BMI>30, n=187). Todos os indivíduos foram genotipados para o polimorfismo -30G>A através da técnica da reação em cadeia da polimerase - polimorfismo do comprimento do fragmento de restrição. ResultadosAs frequências dos genótipos e alelos dos 3 grupos não diferiram entre si (p>0,05). Quando a população de estudo foi categorizada de acordo com a presença de diabete, hiperlipidemia, hipertensão arterial e síndrome metabólica, os genótipos e alelos -30G>A dos subgrupos com e sem essas doenças não diferiram entre si (p>0,05), exceto por uma frequência maior do alelo G no grupo de hiperlipidêmicos quando comparados aos não hiperlipidêmicos (p<0,05). ConclusãoOs achados do presente estudo não confirmam uma associação entre o polimorfismo -30G>A e excesso de peso na população iraniana. Núcleo de Editoração – PUC-Campinas2023-08-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9281Brazilian Journal of Nutrition; Vol. 25 No. 4 (2012): Revista de NutriçãoRevista de Nutrição; Vol. 25 Núm. 4 (2012): Revista de NutriçãoRevista de Nutrição; v. 25 n. 4 (2012): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPenghttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9281/6661Copyright (c) 2023 Mohammad Reza OLADI, Javad BEHRAVAN, Mitra HASSANI, Jamal KASSAEIAN, Amirhossein SAHEBKAR, Shima TAVALLAIE, Roghayeh PAYDAR, Hamidreza SABER, Habib Allah ESMAEILI, Mohsen AZIMI-NEZHAD, Gordon FERNS, Majid GHAYOUR-MOBARHANhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessReza OLADI, Mohammad BEHRAVAN, JavadHASSANI, Mitra KASSAEIAN, Jamal SAHEBKAR, Amirhossein TAVALLAIE, Shima PAYDAR, Roghayeh SABER, HamidrezaAllah ESMAEILI, Habib AZIMI-NEZHAD, MohsenFERNS, Gordon GHAYOUR-MOBARHAN, Majid2023-10-05T19:05:40Zoai:ojs.periodicos.puc-campinas.edu.br:article/9281Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-10-05T19:05:40Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital Polimorfismo -30G |
title |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital |
spellingShingle |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital Reza OLADI, Mohammad Body mass index Glucokinase Metabolic syndrome Obesity Single nucleotide polymorphism Índice de massa corporal Glucoquinase Síndrome metabólica Obesidade Polimorfismo de nucleotídeo único |
title_short |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital |
title_full |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital |
title_fullStr |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital |
title_full_unstemmed |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital |
title_sort |
Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital |
author |
Reza OLADI, Mohammad |
author_facet |
Reza OLADI, Mohammad BEHRAVAN, Javad HASSANI, Mitra KASSAEIAN, Jamal SAHEBKAR, Amirhossein TAVALLAIE, Shima PAYDAR, Roghayeh SABER, Hamidreza Allah ESMAEILI, Habib AZIMI-NEZHAD, Mohsen FERNS, Gordon GHAYOUR-MOBARHAN, Majid |
author_role |
author |
author2 |
BEHRAVAN, Javad HASSANI, Mitra KASSAEIAN, Jamal SAHEBKAR, Amirhossein TAVALLAIE, Shima PAYDAR, Roghayeh SABER, Hamidreza Allah ESMAEILI, Habib AZIMI-NEZHAD, Mohsen FERNS, Gordon GHAYOUR-MOBARHAN, Majid |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Reza OLADI, Mohammad BEHRAVAN, Javad HASSANI, Mitra KASSAEIAN, Jamal SAHEBKAR, Amirhossein TAVALLAIE, Shima PAYDAR, Roghayeh SABER, Hamidreza Allah ESMAEILI, Habib AZIMI-NEZHAD, Mohsen FERNS, Gordon GHAYOUR-MOBARHAN, Majid |
dc.subject.por.fl_str_mv |
Body mass index Glucokinase Metabolic syndrome Obesity Single nucleotide polymorphism Índice de massa corporal Glucoquinase Síndrome metabólica Obesidade Polimorfismo de nucleotídeo único |
topic |
Body mass index Glucokinase Metabolic syndrome Obesity Single nucleotide polymorphism Índice de massa corporal Glucoquinase Síndrome metabólica Obesidade Polimorfismo de nucleotídeo único |
description |
ObjectiveA -30G>A single nucleotide polymorphism in the promoter region of the glucokinase gene has been previously associated with obesity, insulin resistance and diabetes. The present study aimed to evaluate the association of this polymorphism with obesity and its comorbidities in a population from Northeast Iran. MethodsFive hundred and forty-two subjects aged 18 to 65 years were included in the study and divided into normal (BMI<25, n=220), overweight (25<BMI<30, n=135) and obese (BMI>30, n=187) groups. All subjects were genotyped for the -30G>A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism technique. ResultsThe genotypes and allele frequencies of the three groups did not differ significantly (p>0.05). When the study population was categorized according to diabetes mellitus, hyperlipidemia, hypertension and metabolic syndrome status, no significant difference in -30G>A genotypes and alleles was found between the subgroups with and without these disorders (p>0.05), apart from a significantly higher frequency of the G allele in the hyperlipidemic vs. non-hyperlipidemic subgroup (p<0.05). ConclusionThe findings of the present study do not support an association between the -30G>A polymorphism and high body mass index in the Iranian population. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9281 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9281 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9281/6661 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 25 No. 4 (2012): Revista de Nutrição Revista de Nutrição; Vol. 25 Núm. 4 (2012): Revista de Nutrição Revista de Nutrição; v. 25 n. 4 (2012): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
_version_ |
1799126072511430656 |