Plasma lipoproteins, triglycerides and glucose profile of cancer patients during bone marrow transplantation

• Autor(a) principal: GARÓFOLO, Adriana
• Data de Publicação: 2023
• Outros Autores: MODESTO, Patrícia Cláudia, Navarro GORDAN, Letícia, PETRILLI, Antonio Sérgio, SEBER, Adriana
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9789
• topic: child; adolescent; lipoproteins; triglycerides; bone marrow transplantation; criança; adolescente; lipoproteínas; triglicérides; transplante de medula óssea

The objective was to evaluate the nutritional metabolic profiles in children and adolescents with cancerundergoing bone marrow transplants. Eighteen bone marrow transplantation patients were prospectivelyevaluated from October 2003 to August 2004. The assessment was based on the biochemical blood analysesof albumin, lipids and glucose at 3 different moments: before the bone marrow transplant, 7 days after thebone marrow transplant and 14 days after the bone marrow transplant. The Friedman test was performed tocompare the distributions between the periods and the Mann’ Whitney test to compare differences in theevolution between the bone marrow transplant groups: autologous versus allogeneic. Fifteen of the 18patients were eligible: seven had leukemia, four lymphoma and four germ cell tumors. The mean age of the 15patients was 10.7±7.1 years. Nine received autologous and six allogeneic-related bone marrow transplants;two used cyclosporin A as an immunosuppressor and three total body irradiation as part of the conditioningregimen. Thirteen of the 15 received parenteral nutrition. The length of stay was 33±14 days. The prevalenceof albumin and HDL-C deficits increased progressively during follow up: 15%, 31% and 46% and 54%, 69%and 85%, respectively. The same result was observed with the glucose and triglyceride levels, showing aprogressive increase in the prevalence of abnormalities during bone marrow transplantation, with values of7%, 43% and 50% and 31%, 69% and 77%, respectively. Total cholesterol and LDL-C levels above the normalwere only observed in one patient at the first moment (before the bone marrow transplant). The analysis of theevolution of the variables during the three periods demonstrated that the HDL-C, glucose and triglyceridelevels changed significantly. No statistically significant differences were observed when comparing patientssubmitted to allogeneic and autologous bone marrow transplants. However, changes in the HDL-C andtriglyceride levels were more accentuated in patients submitted to allogeneic bone marrow transplants. Theresults suggested that metabolic and biochemical changes occur during the period of bone marrowtransplantation. These changes are probably multi-factorial, being associated with nutritional deficits, proteincatabolism and disturbances in the energy metabolism. It is probable that malnutrition, the use of parenteralnutrition, as well as the inflammatory response to and toxicity of the drugs applied are implicated as causalfactors of these abnormalities.