Appetite-related hormone levels in obese women with and without binge eating behavior

• Autor(a) principal: BRANDÃO, Paula Paraguassú
• Data de Publicação: 2023
• Outros Autores: GARCIA-SOUZA, Érica Patrícia, NEVES, Fabiana Alves, PEREIRA, Mário José dos Santos, SICHIER, Rosely, MOURA, Aníbal Sanchez
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9843
• topic: Ghrelin; Insulin; Obesity; PYY 3-36; Binge-eating disorder; Grelina; Insulina; Obesidade; PYY 3-36; Transtorno de compulsão alimentar

ObjectiveThe aim of this study was to evaluate serum levels of appetite-related hormones (peptide YY3-36, total ghrelin, leptin and insulin) before and after consumption of a meal in obese women with and without binge eating episodes and normal weight women.MethodsTwenty-five women aged 32-50 years were invited to participate in this study, including 9 normal weight women without binge eating episodes (20-25kg/m2, group 1), 9 obese women with binge eating episodes (u30kg/m2, group 2), and 7 obese women without binge eating episodes (group 3). Four blood samples were collected from each participant, one being 60 minutes before and three being 15, 45 and 90 minutes after a meal. The composition of the meal was 55% carbohydrates, 15% protein and 30% lipids.ResultsGroup 3 presented increased HOMA-IR (M=2.5, SD=1.04) when compared with group 1 (M=1.5, SD=0.53) and group 2 (M=1.8, SD=0.58), p=0.04. Body mass index (p<0.0001), leptin (p<0.0001) and insulin (p=0.01) were higher in group 3 than in the other groups before and after the meal. Additionally, total ghrelin (p=0.003) and PYY3-36 (p=0.02) levels were lower in group 2 than in the other groups before and after the meal. After adjustment for body mass index, only the lower PYY3-36 level of group 2 remained statistically different from the other groups (p=0.01).ConclusionOur study suggests that lower levels of PYY 3-36 are associated with binge eating in obese women.