Creatine: ergogenic aid with antioxidant potential?
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9590 |
Resumo: | Creatine is largely used as an ergogenic aid with some evidence regarding its positive effect on lean body mass, strength/power and muscle endurance. However, most studies were not capable of identifying biochemical mechanisms that could explain its effect on fatigue or muscle protein turnover. There is also the possibility that some individuals are non-responsive to this supplement. Another possible effect of creatine that has been recently investigated is its antioxidant action, but few studies explored this subject. Nonetheless, it can be emphasized that the antioxidant effect of creatine works in the organism in the following way: 1) Indirectaction as an energy buffer, due to the increase in muscle phosphocreatine concentrations which would favor a reduced production of metabolites of the purine nucleotide cycle (cycle of Lowenstein) and, as a consequence, a drop in the production of hypoxanthine, xanthine, uric acid, and reactive oxygen species; 2) Direct action (a less powerful action when compared with known antioxidants, such as reduced glutathione). Yet, it could still work in association with them. The objective of this work is to review the available data on the two abovementioned mechanisms. |
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Creatine: ergogenic aid with antioxidant potential?Creatina: auxílio ergogênico com potencial antioxidante?ExerciseOxidative stressSupplementationMetabolismCreatineExercícioEstresse oxidativoMetabolismoCreatinaCreatine is largely used as an ergogenic aid with some evidence regarding its positive effect on lean body mass, strength/power and muscle endurance. However, most studies were not capable of identifying biochemical mechanisms that could explain its effect on fatigue or muscle protein turnover. There is also the possibility that some individuals are non-responsive to this supplement. Another possible effect of creatine that has been recently investigated is its antioxidant action, but few studies explored this subject. Nonetheless, it can be emphasized that the antioxidant effect of creatine works in the organism in the following way: 1) Indirectaction as an energy buffer, due to the increase in muscle phosphocreatine concentrations which would favor a reduced production of metabolites of the purine nucleotide cycle (cycle of Lowenstein) and, as a consequence, a drop in the production of hypoxanthine, xanthine, uric acid, and reactive oxygen species; 2) Direct action (a less powerful action when compared with known antioxidants, such as reduced glutathione). Yet, it could still work in association with them. The objective of this work is to review the available data on the two abovementioned mechanisms.A creatina é largamente utilizada como auxilio ergogênico, com algumas evidências quanto ao seu efeito positivo na massa magra, força/potência e resistência muscular. Entretanto, esses estudos não conseguiram identificar potenciais mecanismos bioquímicos que pudessem explicar seu efeito na fadiga ou turnover de proteína muscular, existindo a possibilidade de que alguns indivíduos não sejam responsivos a esse suplemento. Outro possível efeito da creatina, que vem sendo recentemente investigado, é a sua ação antioxidante. Mesmo com poucos trabalhos disponíveis, duas possibilidades existem para explicar esse efeito: 1) Ação indireta como tampão energético, devido ao aumento na concentração tecidual de fosfocreatina, que favoreceria a menor produção de metabólitos do ciclo de degradação de purinas (ciclo de Lowenstein), resultando em queda na formação de hipoxantina, xantina e ácido úrico, assim como em espécies reativas de oxigênio (superóxido, peróxido de hidrogênio e radical hidroxil); 2) Por ação direta, apesar de essa propriedade ser inferior à dos antioxidantes já bem conhecidos, como a glutationa reduzida. Mesmo assim, poderia atuar conjuntamente com estes. O objetivo desta comunicação é relatar dados disponíveis sobre esses dois itens.Núcleo de Editoração – PUC-Campinas2023-09-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9590Brazilian Journal of Nutrition; Vol. 21 No. 3 (2008): Revista de NutriçãoRevista de Nutrição; Vol. 21 Núm. 3 (2008): Revista de NutriçãoRevista de Nutrição; v. 21 n. 3 (2008): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9590/6946Copyright (c) 2023 Tácito Pessoa de SOUZA JUNIOR, Benedito PEREIRAhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPessoa de SOUZA JUNIOR, Tácito PEREIRA, Benedito 2023-09-04T14:39:37Zoai:ojs.periodicos.puc-campinas.edu.br:article/9590Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-09-04T14:39:37Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Creatine: ergogenic aid with antioxidant potential? Creatina: auxílio ergogênico com potencial antioxidante? |
title |
Creatine: ergogenic aid with antioxidant potential? |
spellingShingle |
Creatine: ergogenic aid with antioxidant potential? Pessoa de SOUZA JUNIOR, Tácito Exercise Oxidative stress Supplementation Metabolism Creatine Exercício Estresse oxidativo Metabolismo Creatina |
title_short |
Creatine: ergogenic aid with antioxidant potential? |
title_full |
Creatine: ergogenic aid with antioxidant potential? |
title_fullStr |
Creatine: ergogenic aid with antioxidant potential? |
title_full_unstemmed |
Creatine: ergogenic aid with antioxidant potential? |
title_sort |
Creatine: ergogenic aid with antioxidant potential? |
author |
Pessoa de SOUZA JUNIOR, Tácito |
author_facet |
Pessoa de SOUZA JUNIOR, Tácito PEREIRA, Benedito |
author_role |
author |
author2 |
PEREIRA, Benedito |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Pessoa de SOUZA JUNIOR, Tácito PEREIRA, Benedito |
dc.subject.por.fl_str_mv |
Exercise Oxidative stress Supplementation Metabolism Creatine Exercício Estresse oxidativo Metabolismo Creatina |
topic |
Exercise Oxidative stress Supplementation Metabolism Creatine Exercício Estresse oxidativo Metabolismo Creatina |
description |
Creatine is largely used as an ergogenic aid with some evidence regarding its positive effect on lean body mass, strength/power and muscle endurance. However, most studies were not capable of identifying biochemical mechanisms that could explain its effect on fatigue or muscle protein turnover. There is also the possibility that some individuals are non-responsive to this supplement. Another possible effect of creatine that has been recently investigated is its antioxidant action, but few studies explored this subject. Nonetheless, it can be emphasized that the antioxidant effect of creatine works in the organism in the following way: 1) Indirectaction as an energy buffer, due to the increase in muscle phosphocreatine concentrations which would favor a reduced production of metabolites of the purine nucleotide cycle (cycle of Lowenstein) and, as a consequence, a drop in the production of hypoxanthine, xanthine, uric acid, and reactive oxygen species; 2) Direct action (a less powerful action when compared with known antioxidants, such as reduced glutathione). Yet, it could still work in association with them. The objective of this work is to review the available data on the two abovementioned mechanisms. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9590 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9590 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9590/6946 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Tácito Pessoa de SOUZA JUNIOR, Benedito PEREIRA https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Tácito Pessoa de SOUZA JUNIOR, Benedito PEREIRA https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 21 No. 3 (2008): Revista de Nutrição Revista de Nutrição; Vol. 21 Núm. 3 (2008): Revista de Nutrição Revista de Nutrição; v. 21 n. 3 (2008): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
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1799126074260455424 |