BETA - CAROTENE AND CANCER

Detalhes bibliográficos
Autor(a) principal: Veloso NAVES, Maria Margareth
Data de Publicação: 1998
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/8571
Resumo: The subject β-carotene and cancer has been studied for more than twenty years, through epidemiologic and experimental researches.Observational epidemiologic studies, both prospective and retrospective, have suggested strongly that high intake of vegetables and fruits which are sources of β-carotene is associated with reduced risk of cancer, specially of lung cancer. However, the results of intervention trials do not demonstrate a preventive potential of β-carotene. Nevertheless, in many studies in experimental animals and in cell cultures, this carotenoid had been shown to act as a potent cancer chemopreventive agentand mechanisms have been proposed to explain this protective effect on biological systems. Researchers suggest that β-carotene protects against cancer, in the amounts easily attained by the consumption of a wide variety of diets, and the chronic pharmacological supplementation is not recommended for healthy populations and for heavy smokers.
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spelling BETA - CAROTENE AND CANCERBETA - CAROTENO E CÂNCERnutritional epidemiologychemopreventionneoplasmsexperimental carcinogenscarotenoidsbeta-caroteneepidemiologia nutricionalquimioprevençãoneoplasiascarcinógenoscarotenóidesbeta-carotenoThe subject β-carotene and cancer has been studied for more than twenty years, through epidemiologic and experimental researches.Observational epidemiologic studies, both prospective and retrospective, have suggested strongly that high intake of vegetables and fruits which are sources of β-carotene is associated with reduced risk of cancer, specially of lung cancer. However, the results of intervention trials do not demonstrate a preventive potential of β-carotene. Nevertheless, in many studies in experimental animals and in cell cultures, this carotenoid had been shown to act as a potent cancer chemopreventive agentand mechanisms have been proposed to explain this protective effect on biological systems. Researchers suggest that β-carotene protects against cancer, in the amounts easily attained by the consumption of a wide variety of diets, and the chronic pharmacological supplementation is not recommended for healthy populations and for heavy smokers.Há mais de vinte anos tem-se pesquisado sobre a relação entre β-caroteno e câncer. Inúmeros trabalhos têm tentado esclarecer a hipótese, formulada a partir de achados epidemiológicos e experimentais, de que o carotenóide poderia agir como anticarcinogênico de origem alimentar. Estudos epidemiológicos observacionais, tipo caso-controle e coorte, sugerem que o consumo elevado de frutas e vegetais ricos em β-caroteno reduz o risco de câncer, especialmente de pulmão. Estudos de intervenção em humanos, administrando doses farmacológicas crônicas a milhares de indivíduos, têm demonstrado resultados contraditórios. Pesquisas em animais experimentais e em cultura de células apontam o carotenóide como quimiopreventivo, agindo sobretudo como retinóides, através de conversão metabólica extra-intestinal e como antioxidante de membrana. Conclui-se que o β-caroteno pode proteger contra o câncer, quando suplementado em doses fisiológicas, isto é, cerca de 4 a 6mg/dia. Doses farmacológicas crônicas não estão recomendadas para indivíduos saudáveis e particularmente para tabagistas.Núcleo de Editoração – PUC-Campinas1998-12-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8571Brazilian Journal of Nutrition; Vol. 11 No. 2 (1998): Revista de NutriçãoRevista de Nutrição; Vol. 11 Núm. 2 (1998): Revista de NutriçãoRevista de Nutrição; v. 11 n. 2 (1998): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8571/6030Copyright (c) 2023 Maria Margareth Veloso NAVEShttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Veloso NAVES, Maria Margareth2024-04-08T12:04:21Zoai:ojs.periodicos.puc-campinas.edu.br:article/8571Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2024-04-08T12:04:21Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv BETA - CAROTENE AND CANCER
BETA - CAROTENO E CÂNCER
title BETA - CAROTENE AND CANCER
spellingShingle BETA - CAROTENE AND CANCER
Veloso NAVES, Maria Margareth
nutritional epidemiology
chemoprevention
neoplasms
experimental carcinogens
carotenoids
beta-carotene
epidemiologia nutricional
quimioprevenção
neoplasias
carcinógenos
carotenóides
beta-caroteno
title_short BETA - CAROTENE AND CANCER
title_full BETA - CAROTENE AND CANCER
title_fullStr BETA - CAROTENE AND CANCER
title_full_unstemmed BETA - CAROTENE AND CANCER
title_sort BETA - CAROTENE AND CANCER
author Veloso NAVES, Maria Margareth
author_facet Veloso NAVES, Maria Margareth
author_role author
dc.contributor.author.fl_str_mv Veloso NAVES, Maria Margareth
dc.subject.por.fl_str_mv nutritional epidemiology
chemoprevention
neoplasms
experimental carcinogens
carotenoids
beta-carotene
epidemiologia nutricional
quimioprevenção
neoplasias
carcinógenos
carotenóides
beta-caroteno
topic nutritional epidemiology
chemoprevention
neoplasms
experimental carcinogens
carotenoids
beta-carotene
epidemiologia nutricional
quimioprevenção
neoplasias
carcinógenos
carotenóides
beta-caroteno
description The subject β-carotene and cancer has been studied for more than twenty years, through epidemiologic and experimental researches.Observational epidemiologic studies, both prospective and retrospective, have suggested strongly that high intake of vegetables and fruits which are sources of β-carotene is associated with reduced risk of cancer, specially of lung cancer. However, the results of intervention trials do not demonstrate a preventive potential of β-carotene. Nevertheless, in many studies in experimental animals and in cell cultures, this carotenoid had been shown to act as a potent cancer chemopreventive agentand mechanisms have been proposed to explain this protective effect on biological systems. Researchers suggest that β-carotene protects against cancer, in the amounts easily attained by the consumption of a wide variety of diets, and the chronic pharmacological supplementation is not recommended for healthy populations and for heavy smokers.
publishDate 1998
dc.date.none.fl_str_mv 1998-12-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8571
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/8571
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8571/6030
dc.rights.driver.fl_str_mv Copyright (c) 2023 Maria Margareth Veloso NAVES
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Maria Margareth Veloso NAVES
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 11 No. 2 (1998): Revista de Nutrição
Revista de Nutrição; Vol. 11 Núm. 2 (1998): Revista de Nutrição
Revista de Nutrição; v. 11 n. 2 (1998): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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