Acute citrulline oral supplementation induces greater post-exercise hypotension response in hypertensive than normotensive individuals

• Autor(a) principal: GRANDOLFI, Kamila
• Data de Publicação: 2023
• Outros Autores: CAVALARI, João Vagner, GÓES, Renata Cristina, Doederlein POLITO, Marcos, CASONATTO, Juliano
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/7697
• topic: Blood pressure; Citrulline; Dietary supplements; Exercise; Hypertension

ObjectiveTo investigate whether acute citrulline supplementation might infl uence post-exercise hypotension in normotensive and hypertensive individuals. MethodsFollowing a randomized double-blind design, twenty normotensive (28±7 years, 74±17kg, 1.7±0.09m) and  20 hypertensive individuals (55±12 years, 76±15kg, 1.59±0.09m) were randomly assigned to one of the four experimental groups (Normotensive-Placebo; Normotensive-Citrulline; Hypertensive-Placebo; HypertensiveCitrulline). The placebo groups ingested 6g of corn starch and the citrulline groups ingested 6g of citrulline dissolved in water. The participants performed 40 minutes of walking/running on a treadmill at 60-70% heart rate reserve. Blood pressure was measured immediately after a 60-min exercise session using an oscillometric device and 24-h ambulatory monitoring. ResultsThe post-exercise hypotension was more pronounced in hypertensives and the Hypertensive-Citrulline group showed a consistent systolic blood pressure reduction during the laboratorial phase, which can be seen by looking at the mean of 60 minutes (-15.01mmHg vs -3.14mmHg [P=0.005]; -4.16mmHg [P=0.009]; -6.30mmHg [P=0.033] in comparison with the Normotensive-Placebo, Normotensive-Citrulline, and Hypertensive-Placebo groups, respectively). During ambulatory blood pressure monitoring, the Hypertensive-Citrulline group showed a significant reduction in systolic blood pressure (-21.05mmHg) in the awake period compared with the Normotensive-Citrulline group (-3.17mmHg [P=0.010]). ConclusionAcute citrulline oral supplementation can induce greater post-exercise hypotension response in hypertensive than normotensive individuals.