Adipokines: a new view of adipose tissue

Detalhes bibliográficos
Autor(a) principal: Duque GUIMARÃES, Daniella Esteves
Data de Publicação: 2023
Outros Autores: de Carvalho SARDINHA, Fátima Lúcia, de Moraes MIZURINI, Daniella, TAVARES DO CARMO, Maria das Graças
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9711
Resumo: Leptin is a hormone secreted by adipocytes whose effect on the sympathetic nervous system and endocrine function confers active participation in the control of energy expenditure and appetite. Its identification added to the fat tissues in the human body the role of a multifunctional organ that produces and secretes a number of bioactive peptides and proteins, called adipocytokines. Changes in the amount of fat tissue, such as the ones that occur in obesity, affect the production of most of these factors secreted by adipocytes. Even if these changes are frequently associated with many metabolic disorders and increased risk for cardiovasculardiseases, the role of fat tissue in the development of these complications, considered its endocrine function, continue to be investigated. The concentration of various adipocytokines increase in obesity and have been associated with hypertension (angiotensinogen), fibrinolysis impairment (plasminogen activator inhibitor-1) and insulin resistance (protein that stimulates acylation, tumor necrosis factor-alpha, interleukine-6 and resistin). On the other hand, leptin and adiponectin affect insulin sensitivity. In obesity, insulin resistance is also associated with leptin resistance and reduced plasma levels of adiponectin. Leptin and adiponectin still have complementary and distinct organic functions: adiponectin has potent antiatherogenic activity whileleptin participates in the control of food intake. Some medications used to control diabetes increase adiponectin production in rodents and humans, suggesting that the development of new medications that target the adipocytokines can represent a new therapeutic alternative to prevent insulin resistance and atherosclerosis in obese individuals.
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spelling Adipokines: a new view of adipose tissueAdipocitocinas: uma nova visão do tecido adiposoadipokinesatherosclerosisobesityinsulin resistanceadipose tissueadipocitocinasateroscleroseobesidaderesistência à insulinatecido adiposoLeptin is a hormone secreted by adipocytes whose effect on the sympathetic nervous system and endocrine function confers active participation in the control of energy expenditure and appetite. Its identification added to the fat tissues in the human body the role of a multifunctional organ that produces and secretes a number of bioactive peptides and proteins, called adipocytokines. Changes in the amount of fat tissue, such as the ones that occur in obesity, affect the production of most of these factors secreted by adipocytes. Even if these changes are frequently associated with many metabolic disorders and increased risk for cardiovasculardiseases, the role of fat tissue in the development of these complications, considered its endocrine function, continue to be investigated. The concentration of various adipocytokines increase in obesity and have been associated with hypertension (angiotensinogen), fibrinolysis impairment (plasminogen activator inhibitor-1) and insulin resistance (protein that stimulates acylation, tumor necrosis factor-alpha, interleukine-6 and resistin). On the other hand, leptin and adiponectin affect insulin sensitivity. In obesity, insulin resistance is also associated with leptin resistance and reduced plasma levels of adiponectin. Leptin and adiponectin still have complementary and distinct organic functions: adiponectin has potent antiatherogenic activity whileleptin participates in the control of food intake. Some medications used to control diabetes increase adiponectin production in rodents and humans, suggesting that the development of new medications that target the adipocytokines can represent a new therapeutic alternative to prevent insulin resistance and atherosclerosis in obese individuals.A identificação da leptina, hormônio secretado pelos adipócitos, cujo efeito sobre o sistema nervoso simpático e a função endócrina confere participação ativa no controle do dispêndio energético, bem como do apetite, acrescentou às funções do tecido adiposo no organismo humano o papel de órgão multifuncional, produtor e secretor de inúmeros peptídeos e proteínas bioativas, denominadas adipocitocinas. Alterações na quantidade de tecido adiposo, como ocorrem na obesidade, afetam a produção da maioria desses fatores secretados pelos adipócitos. Ainda que essas alterações estejam freqüentemente associadas às inúmeras disfunções metabólicas e ao aumento do risco de doenças cardiovasculares, permanece sob investigação o envolvimento do tecido adiposo no desenvolvimento dessas complicações, considerada a sua função endócrina. As concentrações de várias adipocitocinas elevam-se na obesidade e têm sido relacionadas à hipertensão (angiotensinogênio), ao prejuízo da fibrinólise (inibidor do ativador de plasminogênio-1) e à resistência à insulina (proteína estimuladora de acilação, fator de necrose tumoral-α, interleucina-6 e resistina). De outro modo, leptina e adiponectina têm efeitos sobre a sensibilidade à insulina. Na obesidade, a resistência insulínica também está relacionada à resistência à leptina e aos teores plasmáticos reduzidos de adiponectina. Leptina e adiponectina ainda exercem efeitos orgânicos adicionais distintos: frente à participação da leptina no controle da ingestão alimentar, a adiponectina apresenta potente ação anti-aterogênica. Algumas drogas utilizadas no controle do diabetes elevam a produção endógena de adiponectina, em roedores e humanos, indicando que o desenvolvimento de novos medicamentos com alvo nas adipocitocinas pode representar uma alternativa terapêutica de prevenção da resistência insulínica e da aterosclerose em indivíduos obesos. Núcleo de Editoração – PUC-Campinas2023-09-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9711Brazilian Journal of Nutrition; Vol. 20 No. 5 (2007): Revista de NutriçãoRevista de Nutrição; Vol. 20 Núm. 5 (2007): Revista de NutriçãoRevista de Nutrição; v. 20 n. 5 (2007): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9711/7058Copyright (c) 2023 Daniella Esteves Duque GUIMARÃES, Fátima Lúcia de Carvalho SARDINHA, Daniella de Moraes MIZURINI, Maria das Graças TAVARES DO CARMOhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDuque GUIMARÃES, Daniella Esteves de Carvalho SARDINHA, Fátima Lúcia de Moraes MIZURINI, Daniella TAVARES DO CARMO, Maria das Graças2023-10-05T18:45:00Zoai:ojs.periodicos.puc-campinas.edu.br:article/9711Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-10-05T18:45Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Adipokines: a new view of adipose tissue
Adipocitocinas: uma nova visão do tecido adiposo
title Adipokines: a new view of adipose tissue
spellingShingle Adipokines: a new view of adipose tissue
Duque GUIMARÃES, Daniella Esteves
adipokines
atherosclerosis
obesity
insulin resistance
adipose tissue
adipocitocinas
aterosclerose
obesidade
resistência à insulina
tecido adiposo
title_short Adipokines: a new view of adipose tissue
title_full Adipokines: a new view of adipose tissue
title_fullStr Adipokines: a new view of adipose tissue
title_full_unstemmed Adipokines: a new view of adipose tissue
title_sort Adipokines: a new view of adipose tissue
author Duque GUIMARÃES, Daniella Esteves
author_facet Duque GUIMARÃES, Daniella Esteves
de Carvalho SARDINHA, Fátima Lúcia
de Moraes MIZURINI, Daniella
TAVARES DO CARMO, Maria das Graças
author_role author
author2 de Carvalho SARDINHA, Fátima Lúcia
de Moraes MIZURINI, Daniella
TAVARES DO CARMO, Maria das Graças
author2_role author
author
author
dc.contributor.author.fl_str_mv Duque GUIMARÃES, Daniella Esteves
de Carvalho SARDINHA, Fátima Lúcia
de Moraes MIZURINI, Daniella
TAVARES DO CARMO, Maria das Graças
dc.subject.por.fl_str_mv adipokines
atherosclerosis
obesity
insulin resistance
adipose tissue
adipocitocinas
aterosclerose
obesidade
resistência à insulina
tecido adiposo
topic adipokines
atherosclerosis
obesity
insulin resistance
adipose tissue
adipocitocinas
aterosclerose
obesidade
resistência à insulina
tecido adiposo
description Leptin is a hormone secreted by adipocytes whose effect on the sympathetic nervous system and endocrine function confers active participation in the control of energy expenditure and appetite. Its identification added to the fat tissues in the human body the role of a multifunctional organ that produces and secretes a number of bioactive peptides and proteins, called adipocytokines. Changes in the amount of fat tissue, such as the ones that occur in obesity, affect the production of most of these factors secreted by adipocytes. Even if these changes are frequently associated with many metabolic disorders and increased risk for cardiovasculardiseases, the role of fat tissue in the development of these complications, considered its endocrine function, continue to be investigated. The concentration of various adipocytokines increase in obesity and have been associated with hypertension (angiotensinogen), fibrinolysis impairment (plasminogen activator inhibitor-1) and insulin resistance (protein that stimulates acylation, tumor necrosis factor-alpha, interleukine-6 and resistin). On the other hand, leptin and adiponectin affect insulin sensitivity. In obesity, insulin resistance is also associated with leptin resistance and reduced plasma levels of adiponectin. Leptin and adiponectin still have complementary and distinct organic functions: adiponectin has potent antiatherogenic activity whileleptin participates in the control of food intake. Some medications used to control diabetes increase adiponectin production in rodents and humans, suggesting that the development of new medications that target the adipocytokines can represent a new therapeutic alternative to prevent insulin resistance and atherosclerosis in obese individuals.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9711
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9711
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9711/7058
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 20 No. 5 (2007): Revista de Nutrição
Revista de Nutrição; Vol. 20 Núm. 5 (2007): Revista de Nutrição
Revista de Nutrição; v. 20 n. 5 (2007): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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