The relationship between serum retinol concentrations and subclinical infection in rural Brazilian children

• Autor(a) principal: França da Silva TELES, Laísla
• Data de Publicação: 2023
• Outros Autores: de Azevedo PAIVA, Adriana, Alves LUZIA, Liania, Leite de LIMA-FERREIRA, Flávia Emília, Resende Gonçalves de CARVALHO, Cecilia Maria, de Carvalho RONDÓ, Patrícia Helen
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/7657
• topic: Child, preschool; Infant; Infection; Rural area; Vitamin A

ObjectiveTo evaluate the relationship between serum retinol concentrations and subclinical infection in children from rural settlements. MethodsA cross-sectional population-based study was carried out in nine rural settlements in the northeastern region of Brazil, involving 118 children aged 6 to 59 months. The relationship between serum retinol and C-Reactive Protein levels, an important marker of infectious and inflammatory processes, was investigated by multiple linear regression, controlling for demographic, socioeconomic and nutritional variables. Serum retinol and C-Reactive Protein were measured, respectively, by High Performance Liquid Chromatography and immunoturbidimetric assay in automated equipment. ResultsVitamin A deficiency (retinol <0.70μmol/L) was identified in 9.3% of the children. C-Reactive Protein was the only predictor of retinol concentrations in the final regression model, causing a 0.728μmol/L reduction in retinol concentrations in the studied children (p=0.008). ConclusionVitamin A deficiency is a problem of mild/moderate severity and measures to control infectious diseases in this population are fundamental to prevent and/or combat this problem.