Acute caffeine intake lowers glycemia before and after acute physical exercise in diabetic rats

• Autor(a) principal: da SILVA, Luiz Augusto
• Data de Publicação: 2023
• Outros Autores: Aparecido PEREIRA, Ricardo, TÚRMINA, Janaína Angela, Ilvan KERPPERS, Ivo, ALTIMARI, Leandro Ricardo, Maneck MALFATTI, Carlos Ricardo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/8296
• topic: Caffeine; Diabetes Mellitus; Exercise; Glycemia; Cafeína; Diabetes Mellitus; Exercício; Glicemia

ObjectiveThe present study investigated the effects of caffeine supplementation combined with acute physical exercise on the glycemic response of diabetic rats. MethodsThirty-two 60-day-old rats with a mean weight of 238±3 g were divided into four groups: control, control caffeine, diabetes, and diabetes/caffeine. Diabetes was induced by 60 mg/kg of streptozotocin intraperitoneally. The control groups received an acute dose of caffeine (6 mg) or saline 60 minutes before exercise. The animals were then forced to swim for 60 minutes carrying a ballast weighing 6% of their body weight, producing lactacidemia compatible with the maximum lactate production during the steady state (5.5 mmol/L). After the acute exercise session, the animals were sacrificed and their blood collected for glucose analysis. The cardiovascular responses were measured before and after supplementation by tail cuff plethysmography. The one-way Analysisof Variance (Anova) was realized with post hoc of Student-Newman-Keuls to analyse the statistical differences between the supplementations, considering p<0.05. ResultsCaffeine at a dose of 6 mg/kg did not change the cardiovascular responses. However, compared with the control groups, caffeine reduced the blood glucose (42%, p<0.05) of diabetic rats after 60 minutes of exercise. ConclusionAcute caffeine ingestion together with exercise can increase glucose uptake without changing cardiovascular responses in animal models.