Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats

Detalhes bibliográficos
Autor(a) principal: Corrêa PINTO JÚNIOR, Danilo Antônio
Data de Publicação: 2023
Outros Autores: Monteiro SERAPHIM, Patricia
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9247
Resumo: ObjectiveObesity is a strong predictor of some kinds of diseases. High intake of high-fat foods contributes significantly to the growth of the obese population globally. The aim of this study was to verify if consumption of a cafeteria diet for fourteen weeks could increase white fat mass, body weight and skeletal muscle mass and promote insulin resistance in male Wistar rats. MethodsTwenty animals were divided into two groups: control and obese. Both were fed standard chow and water ad libitum. Additionally, a cafeteria diet consisting of bacon, bologna sausage, sandwich cookies and soft drink was given to the obese group. ResultsThe obese group was significantly heavier (p<0.0001) than controls from the second week until the end of the cafeteria-diet intervention. Absolute and relative fat mass, liver weight and Lee Index increased significantly (p<0.05) in the obese group. Furthermore, the obese group had lower (p<0.05) insulin sensitivity than the control group. ConclusionIn conclusion, fourteen weeks of cafeteria diet promoted a progressive increase of fat mass and insulin resistance. Therefore, this is a great and inexpensive diet-induced insulin resistance model. 
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spelling Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar ratsDieta de cafeteria por quatorze semanas pode causar obesidade e resistência insulínica em ratos WistarCafeteria dietHigh-fat foodInsulin resistanceObesityDieta de cafeteriaAlimento hipercalóricoResistência à insulinaObesidadeObjectiveObesity is a strong predictor of some kinds of diseases. High intake of high-fat foods contributes significantly to the growth of the obese population globally. The aim of this study was to verify if consumption of a cafeteria diet for fourteen weeks could increase white fat mass, body weight and skeletal muscle mass and promote insulin resistance in male Wistar rats. MethodsTwenty animals were divided into two groups: control and obese. Both were fed standard chow and water ad libitum. Additionally, a cafeteria diet consisting of bacon, bologna sausage, sandwich cookies and soft drink was given to the obese group. ResultsThe obese group was significantly heavier (p<0.0001) than controls from the second week until the end of the cafeteria-diet intervention. Absolute and relative fat mass, liver weight and Lee Index increased significantly (p<0.05) in the obese group. Furthermore, the obese group had lower (p<0.05) insulin sensitivity than the control group. ConclusionIn conclusion, fourteen weeks of cafeteria diet promoted a progressive increase of fat mass and insulin resistance. Therefore, this is a great and inexpensive diet-induced insulin resistance model. ObjetivoA obesidade é um forte preditor de alguns tipos de doenças. A grande oferta de comida e a predominância de ácidos graxos presentes na maioria dos alimentos contribuem diretamente para o aumento da população obesa no mundo. O objetivo do estudo foi verificar se uma dieta de cafeteria durante um período de catorze semanas pode causar aumento dos pesos de tecido adiposo branco, corporal e muscular e provocar um quadro de resistência insulínica em ratos machos Wistar. MétodosVinte ratos machos Wistar foram divididos em dois grupos: controle e obeso. Os dois grupos foram alimentados com ração padrão e água ad libitum. Ao grupo obeso foi ofertada dieta ocidental, composta por salsicha, mortadela, bolacha recheada, bacon e refrigerante. ResultadosOs animais do grupo obeso estavam significantemente mais pesados a partir da segunda semana de tratamento e essa diferença permaneceu até o final do estudo (p<0,0001). O peso absoluto e relativo do tecido adiposo branco e do fígado, e o Índice de Lee foram maiores no grupo obeso (p<0,05), que apresentou uma menor sensibilidade à insulina no final do estudo quando comparado ao grupo controle (p<0,05). Podemos observar que a dieta cafeteria promoveu um aumento progressivo e significativo da massa de gordura corporal associada à disfunção da ação da insulina. ConclusãoConclui-se que uma dieta de cafeteria por um período de catorze semanas é capaz de promover aumento progressivo da massa adiposa associada à disfunção da insulina, sendo ótimo e fácil modelo de para induzir resistência à insulina.Núcleo de Editoração – PUC-Campinas2023-08-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9247Brazilian Journal of Nutrition; Vol. 25 No. 3 (2012): Revista de NutriçãoRevista de Nutrição; Vol. 25 Núm. 3 (2012): Revista de NutriçãoRevista de Nutrição; v. 25 n. 3 (2012): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9247/6628Copyright (c) 2023 Danilo Antônio Corrêa PINTO JÚNIOR, Patricia Monteiro SERAPHIMhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Corrêa PINTO JÚNIOR, Danilo AntônioMonteiro SERAPHIM, Patricia 2023-10-05T19:03:21Zoai:ojs.periodicos.puc-campinas.edu.br:article/9247Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-10-05T19:03:21Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
Dieta de cafeteria por quatorze semanas pode causar obesidade e resistência insulínica em ratos Wistar
title Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
spellingShingle Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
Corrêa PINTO JÚNIOR, Danilo Antônio
Cafeteria diet
High-fat food
Insulin resistance
Obesity
Dieta de cafeteria
Alimento hipercalórico
Resistência à insulina
Obesidade
title_short Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
title_full Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
title_fullStr Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
title_full_unstemmed Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
title_sort Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
author Corrêa PINTO JÚNIOR, Danilo Antônio
author_facet Corrêa PINTO JÚNIOR, Danilo Antônio
Monteiro SERAPHIM, Patricia
author_role author
author2 Monteiro SERAPHIM, Patricia
author2_role author
dc.contributor.author.fl_str_mv Corrêa PINTO JÚNIOR, Danilo Antônio
Monteiro SERAPHIM, Patricia
dc.subject.por.fl_str_mv Cafeteria diet
High-fat food
Insulin resistance
Obesity
Dieta de cafeteria
Alimento hipercalórico
Resistência à insulina
Obesidade
topic Cafeteria diet
High-fat food
Insulin resistance
Obesity
Dieta de cafeteria
Alimento hipercalórico
Resistência à insulina
Obesidade
description ObjectiveObesity is a strong predictor of some kinds of diseases. High intake of high-fat foods contributes significantly to the growth of the obese population globally. The aim of this study was to verify if consumption of a cafeteria diet for fourteen weeks could increase white fat mass, body weight and skeletal muscle mass and promote insulin resistance in male Wistar rats. MethodsTwenty animals were divided into two groups: control and obese. Both were fed standard chow and water ad libitum. Additionally, a cafeteria diet consisting of bacon, bologna sausage, sandwich cookies and soft drink was given to the obese group. ResultsThe obese group was significantly heavier (p<0.0001) than controls from the second week until the end of the cafeteria-diet intervention. Absolute and relative fat mass, liver weight and Lee Index increased significantly (p<0.05) in the obese group. Furthermore, the obese group had lower (p<0.05) insulin sensitivity than the control group. ConclusionIn conclusion, fourteen weeks of cafeteria diet promoted a progressive increase of fat mass and insulin resistance. Therefore, this is a great and inexpensive diet-induced insulin resistance model. 
publishDate 2023
dc.date.none.fl_str_mv 2023-08-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9247
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9247
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9247/6628
dc.rights.driver.fl_str_mv Copyright (c) 2023 Danilo Antônio Corrêa PINTO JÚNIOR, Patricia Monteiro SERAPHIM
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Danilo Antônio Corrêa PINTO JÚNIOR, Patricia Monteiro SERAPHIM
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 25 No. 3 (2012): Revista de Nutrição
Revista de Nutrição; Vol. 25 Núm. 3 (2012): Revista de Nutrição
Revista de Nutrição; v. 25 n. 3 (2012): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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