Omega-3 fatty acids reduce the development of preneoplasic lesions

Detalhes bibliográficos
Autor(a) principal: Teixeira HENRIQUES, Viviana
Data de Publicação: 2023
Outros Autores: Ganns Chaves DIAS, Cristina Maria, Castro FRANCESCHINI, Sylvia do Carmo, SABARENSE, Céphora Maria, Brunoro COSTA, Neuza Maria, Alvarez LEITE, Jacqueline Isaura, Gouveia PELUZIO, Maria do Carmo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9475
Resumo: ObjectiveThe purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. MethodsA total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. ResultsThe omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. ConclusionThese results suggest that omega-3 may slow the progress of colorectal carcinogenesis.
id PUC_CAMP-2_8b056f3e46da005d9c27d9afcfdbdc43
oai_identifier_str oai:ojs.periodicos.puc-campinas.edu.br:article/9475
network_acronym_str PUC_CAMP-2
network_name_str Revista de Nutrição
repository_id_str
spelling Omega-3 fatty acids reduce the development of preneoplasic lesionsÁcidos graxos ômega-3 reduzem o desenvolvimento de lesões pré-neoplásicasFatty acidsPrecancerousDietary supplementsÁcidos graxosCondições pré-cancerosasSuplementos dietéticosObjectiveThe purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. MethodsA total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. ResultsThe omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. ConclusionThese results suggest that omega-3 may slow the progress of colorectal carcinogenesis.ObjetivoO objetivo do estudo foi avaliar o potencial anticarcinogênico da suplementação com ômega-3 em reduzir lesões pré-neoplásicas induzidas em intestino de ratos Wistar. MétodosRatos Wistar machos, com 11 semanas de idade (Rattus norvergicus), foram subdivididos em dois grupos: grupo controle (n=25) e grupo ômega-3 (n=28). Os focus de criptas aberrantes foram induzidos pela 1,2 dimetilhidrazina. A incorporação dos ácidos graxos ômega-3 suplementados foi avaliada pela identificação do perfil de ácidos graxos da gordura intra-abdominal e do fígado por cromatografia gasosa. ResultadosO grupo ômega-3 apresentou menor consumo da dieta e menor ganho de peso (p<0,05) do que o grupo controle. O número de focus de criptas aberrantes foi reduzido em 55,34% como conseqüência da suplementação dietética com ômega-3. Os focus com três ou mais do que três criptas diminuíram 57,14% entre a 13ª a 28ª semanas. Não foi verificada diferença estatística para o conteúdo de ácido docosahexaenóico. ConclusãoO resultado sugere que o ômega-3 pode reduzir a evolução da carcinogênese colorretal. Núcleo de Editoração – PUC-Campinas2023-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9475Brazilian Journal of Nutrition; Vol. 22 No. 2 (2009): Revista de NutriçãoRevista de Nutrição; Vol. 22 Núm. 2 (2009): Revista de NutriçãoRevista de Nutrição; v. 22 n. 2 (2009): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPenghttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9475/6842Copyright (c) 2023 Viviana Teixeira HENRIQUES, Cristina Maria Ganns Chaves DIAS, Sylvia do Carmo Castro FRANCESCHINI, Céphora Maria SABARENSE, Neuza Maria Brunoro COSTA, Jacqueline Isaura Alvarez LEITE, Maria do Carmo Gouveia PELUZIOhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTeixeira HENRIQUES, Viviana Ganns Chaves DIAS, Cristina Maria Castro FRANCESCHINI, Sylvia do Carmo SABARENSE, Céphora Maria Brunoro COSTA, Neuza MariaAlvarez LEITE, Jacqueline Isaura Gouveia PELUZIO, Maria do Carmo2023-08-30T16:31:52Zoai:ojs.periodicos.puc-campinas.edu.br:article/9475Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-08-30T16:31:52Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Omega-3 fatty acids reduce the development of preneoplasic lesions
Ácidos graxos ômega-3 reduzem o desenvolvimento de lesões pré-neoplásicas
title Omega-3 fatty acids reduce the development of preneoplasic lesions
spellingShingle Omega-3 fatty acids reduce the development of preneoplasic lesions
Teixeira HENRIQUES, Viviana
Fatty acids
Precancerous
Dietary supplements
Ácidos graxos
Condições pré-cancerosas
Suplementos dietéticos
title_short Omega-3 fatty acids reduce the development of preneoplasic lesions
title_full Omega-3 fatty acids reduce the development of preneoplasic lesions
title_fullStr Omega-3 fatty acids reduce the development of preneoplasic lesions
title_full_unstemmed Omega-3 fatty acids reduce the development of preneoplasic lesions
title_sort Omega-3 fatty acids reduce the development of preneoplasic lesions
author Teixeira HENRIQUES, Viviana
author_facet Teixeira HENRIQUES, Viviana
Ganns Chaves DIAS, Cristina Maria
Castro FRANCESCHINI, Sylvia do Carmo
SABARENSE, Céphora Maria
Brunoro COSTA, Neuza Maria
Alvarez LEITE, Jacqueline Isaura
Gouveia PELUZIO, Maria do Carmo
author_role author
author2 Ganns Chaves DIAS, Cristina Maria
Castro FRANCESCHINI, Sylvia do Carmo
SABARENSE, Céphora Maria
Brunoro COSTA, Neuza Maria
Alvarez LEITE, Jacqueline Isaura
Gouveia PELUZIO, Maria do Carmo
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira HENRIQUES, Viviana
Ganns Chaves DIAS, Cristina Maria
Castro FRANCESCHINI, Sylvia do Carmo
SABARENSE, Céphora Maria
Brunoro COSTA, Neuza Maria
Alvarez LEITE, Jacqueline Isaura
Gouveia PELUZIO, Maria do Carmo
dc.subject.por.fl_str_mv Fatty acids
Precancerous
Dietary supplements
Ácidos graxos
Condições pré-cancerosas
Suplementos dietéticos
topic Fatty acids
Precancerous
Dietary supplements
Ácidos graxos
Condições pré-cancerosas
Suplementos dietéticos
description ObjectiveThe purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. MethodsA total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. ResultsThe omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. ConclusionThese results suggest that omega-3 may slow the progress of colorectal carcinogenesis.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9475
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9475
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9475/6842
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 22 No. 2 (2009): Revista de Nutrição
Revista de Nutrição; Vol. 22 Núm. 2 (2009): Revista de Nutrição
Revista de Nutrição; v. 22 n. 2 (2009): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
_version_ 1799126073647038464

Registros relacionados