Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits

Detalhes bibliográficos
Autor(a) principal: Ramos Paes LIMA, Leonardo
Data de Publicação: 2003
Outros Autores: Toledo de OLIVEIRA, Tânia, NAGEM, Tanus Jorge
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9144
Resumo: The objective of this study was to evaluate the therapeutic action of quercetin, bixin and norbixin, in the daily dose of 0,01mol/kg, in hyperlipidemic rabbits induced by cholesterol at 0.5% and colic acid at 0.1%, during the period of twenty-eight days, after which they were anesthetized and samples of blood were collected, in order to determine cholesterol, HDL-cholesterol, triacylglycerols, urea, creatinine, uric acid, total proteins, calcium, aspartate aminotransferase and alanine aminotransferase. These researchs are important to verify the effects of flavonoids and natural dyes on the metabolism of these constituents, in order to study hepatic orrenal disorders. The results showed that cholesterol was reduced by bixin (-44.03%) and by quercetin (-35.07%), while the association reduced urea in 5.73%. None of the constituents analyzed in this study presented deleterious effects and it was not possible to demonstrate the innocuity of these compounds.
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spelling Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbitsEfeitos do flavonóide quercetina e dos corantes bixina e norbixina sobre parâmetros sanguíneos de coelhosquercetinbixinnorbixinmetabolismNew Zealand rabbitscholesterollipoproteinsHDL-cholesterolureafavonesquercetinabixinanorbixinametabolismocoelhos da raça Nova Zelândiacolesterollipoproteínas do colesterol-HDLuréiaflavonasThe objective of this study was to evaluate the therapeutic action of quercetin, bixin and norbixin, in the daily dose of 0,01mol/kg, in hyperlipidemic rabbits induced by cholesterol at 0.5% and colic acid at 0.1%, during the period of twenty-eight days, after which they were anesthetized and samples of blood were collected, in order to determine cholesterol, HDL-cholesterol, triacylglycerols, urea, creatinine, uric acid, total proteins, calcium, aspartate aminotransferase and alanine aminotransferase. These researchs are important to verify the effects of flavonoids and natural dyes on the metabolism of these constituents, in order to study hepatic orrenal disorders. The results showed that cholesterol was reduced by bixin (-44.03%) and by quercetin (-35.07%), while the association reduced urea in 5.73%. None of the constituents analyzed in this study presented deleterious effects and it was not possible to demonstrate the innocuity of these compounds.Avaliou-se a ação terapêutica da quercetina, bixina e norbixina, na dose diária de 0,01mol/kg, em coelhos hiperlipidêmicos induzidos por colesterol a 0,5% e ácido cólico a 0,1%, durante o período de vinte e oito dias, após o qual foram dosados colesterol, colesterol-HDL, triacilgliceróis, uréia, creatinina, ácido úrico, proteínas totais, cálcio, aspartato aminotransferase e alanina aminotransferase. Estes estudos são importante para se verificarem os efeitos de flavonóides e corantes sobre o metabolismo destas substâncias, permitindo a interpretação de desordens hepáticas ou renais. Os resultados mostraram que os teores de colesterol foram menores para os animais tratados com bixina (-4,03%) e quercetina (-35,07%), enquanto sua associação reduziu o nível de uréia em 5,73%. Nenhuma das substâncias testadas apresentou efeitos deletérios, todavia, não é possível demonstrar a inocuidade destes compostos.Núcleo de Editoração – PUC-Campinas2003-09-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9144Brazilian Journal of Nutrition; Vol. 16 No. 3 (2003): Revista de NutriçãoRevista de Nutrição; Vol. 16 Núm. 3 (2003): Revista de NutriçãoRevista de Nutrição; v. 16 n. 3 (2003): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9144/6529Copyright (c) 2023 Leonardo Ramos Paes LIMA, Tânia Toledo de OLIVEIRA, Tanus Jorge NAGEMhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Ramos Paes LIMA, Leonardo Toledo de OLIVEIRA, TâniaNAGEM, Tanus Jorge 2024-04-08T14:11:27Zoai:ojs.periodicos.puc-campinas.edu.br:article/9144Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2024-04-08T14:11:27Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
Efeitos do flavonóide quercetina e dos corantes bixina e norbixina sobre parâmetros sanguíneos de coelhos
title Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
spellingShingle Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
Ramos Paes LIMA, Leonardo
quercetin
bixin
norbixin
metabolism
New Zealand rabbits
cholesterol
lipoproteins
HDL-cholesterol
urea
favones
quercetina
bixina
norbixina
metabolismo
coelhos da raça Nova Zelândia
colesterol
lipoproteínas do colesterol-HDL
uréia
flavonas
title_short Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
title_full Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
title_fullStr Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
title_full_unstemmed Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
title_sort Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
author Ramos Paes LIMA, Leonardo
author_facet Ramos Paes LIMA, Leonardo
Toledo de OLIVEIRA, Tânia
NAGEM, Tanus Jorge
author_role author
author2 Toledo de OLIVEIRA, Tânia
NAGEM, Tanus Jorge
author2_role author
author
dc.contributor.author.fl_str_mv Ramos Paes LIMA, Leonardo
Toledo de OLIVEIRA, Tânia
NAGEM, Tanus Jorge
dc.subject.por.fl_str_mv quercetin
bixin
norbixin
metabolism
New Zealand rabbits
cholesterol
lipoproteins
HDL-cholesterol
urea
favones
quercetina
bixina
norbixina
metabolismo
coelhos da raça Nova Zelândia
colesterol
lipoproteínas do colesterol-HDL
uréia
flavonas
topic quercetin
bixin
norbixin
metabolism
New Zealand rabbits
cholesterol
lipoproteins
HDL-cholesterol
urea
favones
quercetina
bixina
norbixina
metabolismo
coelhos da raça Nova Zelândia
colesterol
lipoproteínas do colesterol-HDL
uréia
flavonas
description The objective of this study was to evaluate the therapeutic action of quercetin, bixin and norbixin, in the daily dose of 0,01mol/kg, in hyperlipidemic rabbits induced by cholesterol at 0.5% and colic acid at 0.1%, during the period of twenty-eight days, after which they were anesthetized and samples of blood were collected, in order to determine cholesterol, HDL-cholesterol, triacylglycerols, urea, creatinine, uric acid, total proteins, calcium, aspartate aminotransferase and alanine aminotransferase. These researchs are important to verify the effects of flavonoids and natural dyes on the metabolism of these constituents, in order to study hepatic orrenal disorders. The results showed that cholesterol was reduced by bixin (-44.03%) and by quercetin (-35.07%), while the association reduced urea in 5.73%. None of the constituents analyzed in this study presented deleterious effects and it was not possible to demonstrate the innocuity of these compounds.
publishDate 2003
dc.date.none.fl_str_mv 2003-09-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9144
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9144
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9144/6529
dc.rights.driver.fl_str_mv Copyright (c) 2023 Leonardo Ramos Paes LIMA, Tânia Toledo de OLIVEIRA, Tanus Jorge NAGEM
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Leonardo Ramos Paes LIMA, Tânia Toledo de OLIVEIRA, Tanus Jorge NAGEM
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 16 No. 3 (2003): Revista de Nutrição
Revista de Nutrição; Vol. 16 Núm. 3 (2003): Revista de Nutrição
Revista de Nutrição; v. 16 n. 3 (2003): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
_version_ 1799126071891722240

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