Effect of varied doses of retinoic acid on young rats’ bone resistance

Detalhes bibliográficos
Autor(a) principal: SOUZA, Luciana Bronzi de
Data de Publicação: 2023
Outros Autores: FREIRE, Cristiana Maria Murbach, ALMEIDA, Renata Noêmia Alves de, MÜLLER, Sérgio Swain, PAIVA, Sérgio Alberto Rupp, MAZETO, Gláucia Maria Ferreira da Silva
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9432
Resumo: ObjectiveThis study assessed the effects of different doses of all-trans retinoic acid on bone resistance by conducting a biomechanical flexion study on young rats’ tibias.MethodsFifty-eight young rats were divided into four groups according to the all-trans retinoic acid content of their diets: control group (n=15), chow not enriched with all-trans retinoic acid; chow enriched with 0.3mg of all-trans retinoic acid per kilogram (n=13); chow enriched with 10mg of all-trans retinoic acid per kilogram (n=15); and chow enriched with 50mg of all-trans retinoic acid per kilogram (n-15). After 30 days of this diet, the animals were killed, their left paws were frozen and dissected and the tibias were submitted to the flexion study which assessed maximum force and shear modulus. One-way analysis of variance was used with significance set at p<0.05.ResultsThe mean maximum force values in newtons (SD) were: control group =37.94, SD=4.76; 0.3mg group = 36.49, SD= 4.38; 10mg group = 40.12, SD=6.03; 50mg group =35.68, SD=5.22 (p=0.107). The mean shear modulus values (SD) in newtons/millimeter were: control group =31.84, SD=6.75; 0.3mg group =29.18, SD=4.35; 10mg group =35.48, SD=8.14; 50mg group =30.31, SD=7.14 (p=0.85).ConclusionBiomechanical studies showed that different doses of all-trans retinoic acid for 30 days had no effect on young rats’ bone resistance.
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spelling Effect of varied doses of retinoic acid on young rats’ bone resistanceEfeito de diferentes doses de ácido retinoico sobre a resistência óssea de ratos jovensBiomechanicsOsteoporosisRatsTretinoinBiomecânicaOsteoporoseRatosTretinoínaObjectiveThis study assessed the effects of different doses of all-trans retinoic acid on bone resistance by conducting a biomechanical flexion study on young rats’ tibias.MethodsFifty-eight young rats were divided into four groups according to the all-trans retinoic acid content of their diets: control group (n=15), chow not enriched with all-trans retinoic acid; chow enriched with 0.3mg of all-trans retinoic acid per kilogram (n=13); chow enriched with 10mg of all-trans retinoic acid per kilogram (n=15); and chow enriched with 50mg of all-trans retinoic acid per kilogram (n-15). After 30 days of this diet, the animals were killed, their left paws were frozen and dissected and the tibias were submitted to the flexion study which assessed maximum force and shear modulus. One-way analysis of variance was used with significance set at p<0.05.ResultsThe mean maximum force values in newtons (SD) were: control group =37.94, SD=4.76; 0.3mg group = 36.49, SD= 4.38; 10mg group = 40.12, SD=6.03; 50mg group =35.68, SD=5.22 (p=0.107). The mean shear modulus values (SD) in newtons/millimeter were: control group =31.84, SD=6.75; 0.3mg group =29.18, SD=4.35; 10mg group =35.48, SD=8.14; 50mg group =30.31, SD=7.14 (p=0.85).ConclusionBiomechanical studies showed that different doses of all-trans retinoic acid for 30 days had no effect on young rats’ bone resistance.ObjetivoAvaliar os efeitos da suplementação de diferentes doses de todo-trans ácido retinóico sobre a resistência óssea, por meio de ensaio biomecânico de flexão, em tíbia de ratos jovens.MétodosForam estudados 58 ratos jovens, com quatro diferentes doses de vitamina A em suas dietas, sendo divididos em 4 grupos: grupo controle (n=15), sem acréscimo de todo-trans ácido retinoico; grupo com acréscimo de 0,3mg de todo-trans ácido retinoico por kg de ração (n=13); grupo com 10mg de todo-trans ácido retinoico por kg de ração (n=15); e grupo com 50mg de todo-trans ácido retinoico por kg de ração (n=15). O estudo durou 30 dias. Após o sacrifício dos animais, suas patas esquerdas foram congeladas, dissecadas e as tíbias submetidas ao ensaio de flexão. Foram avaliados a carga máxima e o coeficiente de rigidez. Foi aplicada análise de variância one-way. O nível de significância estatístico adotado foi p<0,05. ResultadosOs valores médios de carga máxima (em Newton) foram: grupo-controle =37,94, DP=4,76; grupo todo-trans ácido retinoico 0,3=36,49, DP= 4,38; grupo todo-trans ácido retinoico 10=40,12, DP=6,03; grupo todo-transácido retinoico 50=35,68, DP=5,22 (p=0,107). Os valores médios de coeficiente de rigidez (em Newton/milímetros) foram: grupo-controle =31,84 DP=6,75; grupo todo trans ácido retinoico 0,3=29,18, DP=4,35; grupo todo-trans ácido retinoico 10=35,48, DP=8,14; grupo todo-trans ácido retinoico 50=30,31, DP=7,14 (p=0,85). ConclusãoConclui-se que a exposição a diferentes doses de todo-trans ácido retinoico, em ratos, durante 30 dias, não exerce efeito sobre a resistência óssea, quando avaliada por ensaios biomecânicos.Núcleo de Editoração – PUC-Campinas2023-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9432Brazilian Journal of Nutrition; Vol. 24 No. 3 (2011): Revista de NutriçãoRevista de Nutrição; Vol. 24 Núm. 3 (2011): Revista de NutriçãoRevista de Nutrição; v. 24 n. 3 (2011): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9432/6803Copyright (c) 2023 Luciana Bronzi de SOUZA, Cristiana Maria Murbach FREIRE, Renata Noêmia Alves de ALMEIDA, Sérgio Swain MÜLLER, Sérgio Alberto Rupp PAIVA, Gláucia Maria Ferreira da Silva MAZETOhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess SOUZA, Luciana Bronzi deFREIRE, Cristiana Maria Murbach ALMEIDA, Renata Noêmia Alves deMÜLLER, Sérgio Swain PAIVA, Sérgio Alberto Rupp MAZETO, Gláucia Maria Ferreira da Silva 2023-08-31T16:19:55Zoai:ojs.periodicos.puc-campinas.edu.br:article/9432Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-08-31T16:19:55Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Effect of varied doses of retinoic acid on young rats’ bone resistance
Efeito de diferentes doses de ácido retinoico sobre a resistência óssea de ratos jovens
title Effect of varied doses of retinoic acid on young rats’ bone resistance
spellingShingle Effect of varied doses of retinoic acid on young rats’ bone resistance
SOUZA, Luciana Bronzi de
Biomechanics
Osteoporosis
Rats
Tretinoin
Biomecânica
Osteoporose
Ratos
Tretinoína
title_short Effect of varied doses of retinoic acid on young rats’ bone resistance
title_full Effect of varied doses of retinoic acid on young rats’ bone resistance
title_fullStr Effect of varied doses of retinoic acid on young rats’ bone resistance
title_full_unstemmed Effect of varied doses of retinoic acid on young rats’ bone resistance
title_sort Effect of varied doses of retinoic acid on young rats’ bone resistance
author SOUZA, Luciana Bronzi de
author_facet SOUZA, Luciana Bronzi de
FREIRE, Cristiana Maria Murbach
ALMEIDA, Renata Noêmia Alves de
MÜLLER, Sérgio Swain
PAIVA, Sérgio Alberto Rupp
MAZETO, Gláucia Maria Ferreira da Silva
author_role author
author2 FREIRE, Cristiana Maria Murbach
ALMEIDA, Renata Noêmia Alves de
MÜLLER, Sérgio Swain
PAIVA, Sérgio Alberto Rupp
MAZETO, Gláucia Maria Ferreira da Silva
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv SOUZA, Luciana Bronzi de
FREIRE, Cristiana Maria Murbach
ALMEIDA, Renata Noêmia Alves de
MÜLLER, Sérgio Swain
PAIVA, Sérgio Alberto Rupp
MAZETO, Gláucia Maria Ferreira da Silva
dc.subject.por.fl_str_mv Biomechanics
Osteoporosis
Rats
Tretinoin
Biomecânica
Osteoporose
Ratos
Tretinoína
topic Biomechanics
Osteoporosis
Rats
Tretinoin
Biomecânica
Osteoporose
Ratos
Tretinoína
description ObjectiveThis study assessed the effects of different doses of all-trans retinoic acid on bone resistance by conducting a biomechanical flexion study on young rats’ tibias.MethodsFifty-eight young rats were divided into four groups according to the all-trans retinoic acid content of their diets: control group (n=15), chow not enriched with all-trans retinoic acid; chow enriched with 0.3mg of all-trans retinoic acid per kilogram (n=13); chow enriched with 10mg of all-trans retinoic acid per kilogram (n=15); and chow enriched with 50mg of all-trans retinoic acid per kilogram (n-15). After 30 days of this diet, the animals were killed, their left paws were frozen and dissected and the tibias were submitted to the flexion study which assessed maximum force and shear modulus. One-way analysis of variance was used with significance set at p<0.05.ResultsThe mean maximum force values in newtons (SD) were: control group =37.94, SD=4.76; 0.3mg group = 36.49, SD= 4.38; 10mg group = 40.12, SD=6.03; 50mg group =35.68, SD=5.22 (p=0.107). The mean shear modulus values (SD) in newtons/millimeter were: control group =31.84, SD=6.75; 0.3mg group =29.18, SD=4.35; 10mg group =35.48, SD=8.14; 50mg group =30.31, SD=7.14 (p=0.85).ConclusionBiomechanical studies showed that different doses of all-trans retinoic acid for 30 days had no effect on young rats’ bone resistance.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9432
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9432
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9432/6803
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 24 No. 3 (2011): Revista de Nutrição
Revista de Nutrição; Vol. 24 Núm. 3 (2011): Revista de Nutrição
Revista de Nutrição; v. 24 n. 3 (2011): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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