EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS

Detalhes bibliográficos
Autor(a) principal: VIANNA DE OLIVEIRA, Ida Maria
Data de Publicação: 2000
Outros Autores: Harue Yoshida de PAULO, Roseane, FUJIMORI, Elizabeth
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/8759
Resumo: The purpose of this study was to evaluate the effect of the acute (post-weaning growth) and chronic (lactating rats undernourished since prenatal period and their pups) caloric restriction on hepatic gamma-glutamyl transpeptidase activity and glutathione levels of rats. Diet consumption was either unrestricted (control group) or 30% restricted (undernourished group).Two trials, one of acutemalnutrition and another of chronic malnutrition, were conducted. Acute restriction caused significant reduction in the weight gain of the growing rats, but chronically undernourished mothers showed a significantly higher weight gain/pup, since they presented fewer pups. No significant alterations in glutathione levels, gamma-glutamyl transpeptidase activity, or even in the hepatic protein concentration were observed under acute or chronic caloric restriction. The less pronounced unbalance in the profile of plasmatic amino acids and in the protein synthesis (consequence of caloric, rather than protein malnutrition) can justify such results.
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spelling EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELSEFEITO DA RESTRIÇÃO ENERGÉTICA NA ATIVIDADE HEPÁTICA DA GAMA-GLUTAMILTRANSPEPTIDASE E NOS NÍVEIS DE GLUTATIONAGamma-glutamyltransferaseglutathioneprotein-energy malnutritiongrowthpregnancylactationgama-glutamiltransferaseglutationadesnutrição protéico-energéticacrescimentogravidezlactaçãoThe purpose of this study was to evaluate the effect of the acute (post-weaning growth) and chronic (lactating rats undernourished since prenatal period and their pups) caloric restriction on hepatic gamma-glutamyl transpeptidase activity and glutathione levels of rats. Diet consumption was either unrestricted (control group) or 30% restricted (undernourished group).Two trials, one of acutemalnutrition and another of chronic malnutrition, were conducted. Acute restriction caused significant reduction in the weight gain of the growing rats, but chronically undernourished mothers showed a significantly higher weight gain/pup, since they presented fewer pups. No significant alterations in glutathione levels, gamma-glutamyl transpeptidase activity, or even in the hepatic protein concentration were observed under acute or chronic caloric restriction. The less pronounced unbalance in the profile of plasmatic amino acids and in the protein synthesis (consequence of caloric, rather than protein malnutrition) can justify such results.Avaliou-se o efeito da restrição energética aguda (crescimento pós-desmame) e crônica (lactantes desnutridas desde o período pré-natal e seus filhotes) na atividade da gama-glutamiltranspeptidase e nos níveis de glutationa. O consumo da dieta foi ad libitum (controle) ou com restrição de 30% (desnutrido), tendo-se conduzido dois ensaios, um de desnutrição aguda e outro de desnutrição crônica. A restrição aguda provocou redução significativa no ganho ponderal dos ratos em crescimento, mas as mães cronicamente desnutridas ganharam significativamente mais peso/filhote, pois apresentaram menor número de filhotes. Não foram observadas alterações significativas nos níveis de glutationa, na atividade da gama-glutamiltranspeptidase e mesmo na concentração de proteína hepática sob o efeito da restrição energética, aguda ou crônica. Menor desequilíbrio no perfil de aminoácidos plasmáticos e na síntese protéica, conseqüente à desnutrição energética e não à protéica, pode justificar estes resultados.Núcleo de Editoração – PUC-Campinas2000-04-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8759Brazilian Journal of Nutrition; Vol. 13 No. 1 (2000): Revista de NutriçãoRevista de Nutrição; Vol. 13 Núm. 1 (2000): Revista de NutriçãoRevista de Nutrição; v. 13 n. 1 (2000): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8759/6174Copyright (c) 2023 Ida Maria VIANNA DE OLIVEIRA, Roseane Harue Yoshida de PAULO, Elizabeth FUJIMORIhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVIANNA DE OLIVEIRA, Ida Maria Harue Yoshida de PAULO, Roseane FUJIMORI, Elizabeth 2024-04-08T12:22:52Zoai:ojs.periodicos.puc-campinas.edu.br:article/8759Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2024-04-08T12:22:52Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
EFEITO DA RESTRIÇÃO ENERGÉTICA NA ATIVIDADE HEPÁTICA DA GAMA-GLUTAMILTRANSPEPTIDASE E NOS NÍVEIS DE GLUTATIONA
title EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
spellingShingle EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
VIANNA DE OLIVEIRA, Ida Maria
Gamma-glutamyltransferase
glutathione
protein-energy malnutrition
growth
pregnancy
lactation
gama-glutamiltransferase
glutationa
desnutrição protéico-energética
crescimento
gravidez
lactação
title_short EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
title_full EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
title_fullStr EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
title_full_unstemmed EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
title_sort EFFECT OF CALORIC RESTRICTION ON HEPATIC GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY AND ON GLUTATHIONE LEVELS
author VIANNA DE OLIVEIRA, Ida Maria
author_facet VIANNA DE OLIVEIRA, Ida Maria
Harue Yoshida de PAULO, Roseane
FUJIMORI, Elizabeth
author_role author
author2 Harue Yoshida de PAULO, Roseane
FUJIMORI, Elizabeth
author2_role author
author
dc.contributor.author.fl_str_mv VIANNA DE OLIVEIRA, Ida Maria
Harue Yoshida de PAULO, Roseane
FUJIMORI, Elizabeth
dc.subject.por.fl_str_mv Gamma-glutamyltransferase
glutathione
protein-energy malnutrition
growth
pregnancy
lactation
gama-glutamiltransferase
glutationa
desnutrição protéico-energética
crescimento
gravidez
lactação
topic Gamma-glutamyltransferase
glutathione
protein-energy malnutrition
growth
pregnancy
lactation
gama-glutamiltransferase
glutationa
desnutrição protéico-energética
crescimento
gravidez
lactação
description The purpose of this study was to evaluate the effect of the acute (post-weaning growth) and chronic (lactating rats undernourished since prenatal period and their pups) caloric restriction on hepatic gamma-glutamyl transpeptidase activity and glutathione levels of rats. Diet consumption was either unrestricted (control group) or 30% restricted (undernourished group).Two trials, one of acutemalnutrition and another of chronic malnutrition, were conducted. Acute restriction caused significant reduction in the weight gain of the growing rats, but chronically undernourished mothers showed a significantly higher weight gain/pup, since they presented fewer pups. No significant alterations in glutathione levels, gamma-glutamyl transpeptidase activity, or even in the hepatic protein concentration were observed under acute or chronic caloric restriction. The less pronounced unbalance in the profile of plasmatic amino acids and in the protein synthesis (consequence of caloric, rather than protein malnutrition) can justify such results.
publishDate 2000
dc.date.none.fl_str_mv 2000-04-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8759
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/8759
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8759/6174
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 13 No. 1 (2000): Revista de Nutrição
Revista de Nutrição; Vol. 13 Núm. 1 (2000): Revista de Nutrição
Revista de Nutrição; v. 13 n. 1 (2000): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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