Short time L-glutamine supplementation of malnourished rats

• Autor(a) principal: TANNUS, Andréa Ferreira Schuwartz
• Data de Publicação: 2023
• Outros Autores: JUNQUEIRA-FRANCO, Márcia Morandi, SUEN, Vivian Marques Miguel, PORTARI, Guilherme Vannucchi, MARCHINI, Júlio Sérgio
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9986
• topic: amino acids; dietary supplements; glutamine; malnutrition; nitrogen; rats; aminoácidos; suplementos dietéticos; glutamina; desnutrição; nitrogênio; ratos

ObjectiveConsidering that in malnourished patients supplemented with L-glutamine the negativity of the nitrogen balance tends to decrease, the present study aimed to determine whether malnourished Wistar rats supplemented with L-glutamine would show lower urinary nitrogen excretion, a greater deposition of nitrogen content in different tissues, and/or an alteration in the plasma amino acid levels.MethodsThe rats were divided into groups: 1) protein-energy malnutrition, 2) protein malnutrition and 3) normally nourished group. The urinary and tissue nitrogen contents were determined by the Kjeldahl method and plasma amino acids by liquid chromatography.ResultsWeight, urinary and tissue nitrogen accumulation were significantly reduced in the group with protein-energy malnutrition, but did not improve with L-glutamine supplementation supplied for a short time. The plasma amino acid concentrations showed no special pattern with L-glutamine supplementation.ConclusionIt was concluded that it was not possible to detect any positive effect of L-glutamine supplementation on the tissue and urinary nitrogen metabolism in malnourished rats.