Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Revista de Nutrição |
| Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9523 |
Resumo: | ObjectiveThe objective was to assess the effects of oral administration of sodium butyrate on colon carcinogenesis. MethodsCarcinogenesis in adult male Wistar rats was induced with 1.2-dimethylhydrazine injections at a dose of 40mg/kg of body weight. A solution of sodium butyrate (3.4%) was given ad libitum for 4 weeks (butyrate group, n=16) instead of water (control group, n=9). Rats were killed 17 weeks after 1.2-dimethylhydrazine administration. Aberrant crypt foci and expression of the messenger ribonucleic acid (mRNA) of cyclins D1 and E were quantified in the colon. Alterations in the fatty acid profile of the colon, liver, intra-abdominal fat and feces were also analyzed. ResultsA significant decrease in aberrant crypt foci was found in the group taking butyrate. No differences were found between the groups in the mRNA expression of cyclins D1 and E. Nevertheless, butyrate intake decreased the content of stearic and oleic acids in the intra-abdominal fat and docosahexaenoic acid in the liver. Moreover, these rats presented higher percentages of linoleic acid in the intra-abdominal fat than control rats. ConclusionThe data indicate that butyrate use in rats reduced preneoplastic lesions and changes in the intra-abdominal fat and fatty acid profile of the liver, commonly found in colon carcinogenesis. |
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Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesisAdministração oral de butirato de sódio reduz lesões pré-neoplásicas quimicamente induzidas na carcinogênese experimentalFatty acidsButyrateCyclinsColonic neoplasms, tumor markers, biologicalÁcidos graxosButiratoCiclinasNeoplasia do colonMarcadores biológicos de tumorObjectiveThe objective was to assess the effects of oral administration of sodium butyrate on colon carcinogenesis. MethodsCarcinogenesis in adult male Wistar rats was induced with 1.2-dimethylhydrazine injections at a dose of 40mg/kg of body weight. A solution of sodium butyrate (3.4%) was given ad libitum for 4 weeks (butyrate group, n=16) instead of water (control group, n=9). Rats were killed 17 weeks after 1.2-dimethylhydrazine administration. Aberrant crypt foci and expression of the messenger ribonucleic acid (mRNA) of cyclins D1 and E were quantified in the colon. Alterations in the fatty acid profile of the colon, liver, intra-abdominal fat and feces were also analyzed. ResultsA significant decrease in aberrant crypt foci was found in the group taking butyrate. No differences were found between the groups in the mRNA expression of cyclins D1 and E. Nevertheless, butyrate intake decreased the content of stearic and oleic acids in the intra-abdominal fat and docosahexaenoic acid in the liver. Moreover, these rats presented higher percentages of linoleic acid in the intra-abdominal fat than control rats. ConclusionThe data indicate that butyrate use in rats reduced preneoplastic lesions and changes in the intra-abdominal fat and fatty acid profile of the liver, commonly found in colon carcinogenesis. ObjetivoAvaliar o efeito da administração oral de butirato de sódio na carcinogênese do cólon. MétodosA carcinogênese em ratos Wistar foi induzida com injeções de 1,2-dimetilhidrazina na dose de 40mg/kg de peso corporal. A solução de butirato de sódio (3,4%) foi oferecida ad libitum por 4 semanas (grupo butirato, n=16), em substituição à água (grupo controle, n=9). Os ratos foram sacrificados na 17ª semana após tratamento com a 1,2-dimetilhidrazina. Focos de criptas aberrantes e a expressão dos genes para o ácido ribonucléico mensageiro (RNAm) das ciclinas D1 e E foram quantificadas no cólon. Alterações no perfil de ácidos graxos do cólon, no fígado, na gordura intra-abdominal e nas fezes foram analisadas. ResultadosUma significante diminuição nos focos de criptas aberrantes foi encontrada no grupo que recebeu butirato. Nenhuma diferença foi encontrada na expressão do RNAm das ciclinas D1 e E entre os grupos. Contudo, a ingestão de butirato diminuiu a quantidade de ácido esteárico e ácido oléico na gordura intra-abdominal e do ácido docosahexanóico no fígado. Além disso, o grupo butirato apresentou maior percentual de ácido linoléico na gordura intra-abdominal, comparado com os ratos do grupo controle. ConclusãoOs dados indicam que o uso de butirato reduz lesões pré-neoplásicas em ratos e diminui as alterações no perfil de ácidos graxos da gordura intra-abdominal e do fígado, comumente encontradas na carcinogênese colônica.Núcleo de Editoração – PUC-Campinas2023-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9523Brazilian Journal of Nutrition; Vol. 22 No. 5 (2009): Revista de NutriçãoRevista de Nutrição; Vol. 22 Núm. 5 (2009): Revista de NutriçãoRevista de Nutrição; v. 22 n. 5 (2009): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPenghttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9523/6890Copyright (c) 2023 Maria do Carmo Gouveia PELUZIO, Ana Paula Boroni MOREIRA, Isabela Campelo de QUEIROZ, Cristina Maria Ganns Chaves DIAS, Sylvia do Carmo Castro FRANCESCHINI, Jacqueline Isaura ALVAREZ-LEITE, Antônio José NATALI, Céphora Maria SABARENSEhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGouveia PELUZIO, Maria do Carmo Boroni MOREIRA, Ana Paula Campelo de QUEIROZ, IsabelaGanns Chaves DIAS, Cristina Maria Castro FRANCESCHINI, Sylvia do Carmo ALVAREZ-LEITE, Jacqueline Isaura NATALI, Antônio JoséSABARENSE, Céphora Maria 2023-12-05T14:43:42Zoai:ojs.periodicos.puc-campinas.edu.br:article/9523Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-12-05T14:43:42Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
| dc.title.none.fl_str_mv |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis Administração oral de butirato de sódio reduz lesões pré-neoplásicas quimicamente induzidas na carcinogênese experimental |
| title |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis |
| spellingShingle |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis Gouveia PELUZIO, Maria do Carmo Fatty acids Butyrate Cyclins Colonic neoplasms, tumor markers, biological Ácidos graxos Butirato Ciclinas Neoplasia do colon Marcadores biológicos de tumor |
| title_short |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis |
| title_full |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis |
| title_fullStr |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis |
| title_full_unstemmed |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis |
| title_sort |
Oral administration of sodium butyrate reduces chemically-induced preneoplastic lesions in experimental carcinogenesis |
| author |
Gouveia PELUZIO, Maria do Carmo |
| author_facet |
Gouveia PELUZIO, Maria do Carmo Boroni MOREIRA, Ana Paula Campelo de QUEIROZ, Isabela Ganns Chaves DIAS, Cristina Maria Castro FRANCESCHINI, Sylvia do Carmo ALVAREZ-LEITE, Jacqueline Isaura NATALI, Antônio José SABARENSE, Céphora Maria |
| author_role |
author |
| author2 |
Boroni MOREIRA, Ana Paula Campelo de QUEIROZ, Isabela Ganns Chaves DIAS, Cristina Maria Castro FRANCESCHINI, Sylvia do Carmo ALVAREZ-LEITE, Jacqueline Isaura NATALI, Antônio José SABARENSE, Céphora Maria |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gouveia PELUZIO, Maria do Carmo Boroni MOREIRA, Ana Paula Campelo de QUEIROZ, Isabela Ganns Chaves DIAS, Cristina Maria Castro FRANCESCHINI, Sylvia do Carmo ALVAREZ-LEITE, Jacqueline Isaura NATALI, Antônio José SABARENSE, Céphora Maria |
| dc.subject.por.fl_str_mv |
Fatty acids Butyrate Cyclins Colonic neoplasms, tumor markers, biological Ácidos graxos Butirato Ciclinas Neoplasia do colon Marcadores biológicos de tumor |
| topic |
Fatty acids Butyrate Cyclins Colonic neoplasms, tumor markers, biological Ácidos graxos Butirato Ciclinas Neoplasia do colon Marcadores biológicos de tumor |
| description |
ObjectiveThe objective was to assess the effects of oral administration of sodium butyrate on colon carcinogenesis. MethodsCarcinogenesis in adult male Wistar rats was induced with 1.2-dimethylhydrazine injections at a dose of 40mg/kg of body weight. A solution of sodium butyrate (3.4%) was given ad libitum for 4 weeks (butyrate group, n=16) instead of water (control group, n=9). Rats were killed 17 weeks after 1.2-dimethylhydrazine administration. Aberrant crypt foci and expression of the messenger ribonucleic acid (mRNA) of cyclins D1 and E were quantified in the colon. Alterations in the fatty acid profile of the colon, liver, intra-abdominal fat and feces were also analyzed. ResultsA significant decrease in aberrant crypt foci was found in the group taking butyrate. No differences were found between the groups in the mRNA expression of cyclins D1 and E. Nevertheless, butyrate intake decreased the content of stearic and oleic acids in the intra-abdominal fat and docosahexaenoic acid in the liver. Moreover, these rats presented higher percentages of linoleic acid in the intra-abdominal fat than control rats. ConclusionThe data indicate that butyrate use in rats reduced preneoplastic lesions and changes in the intra-abdominal fat and fatty acid profile of the liver, commonly found in colon carcinogenesis. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-08-31 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9523 |
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https://periodicos.puc-campinas.edu.br/nutricao/article/view/9523 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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https://periodicos.puc-campinas.edu.br/nutricao/article/view/9523/6890 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Núcleo de Editoração – PUC-Campinas |
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Núcleo de Editoração – PUC-Campinas |
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Brazilian Journal of Nutrition; Vol. 22 No. 5 (2009): Revista de Nutrição Revista de Nutrição; Vol. 22 Núm. 5 (2009): Revista de Nutrição Revista de Nutrição; v. 22 n. 5 (2009): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
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Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
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PUC_CAMP |
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PUC_CAMP |
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Revista de Nutrição |
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Revista de Nutrição |
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Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
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