DNA damage and postural balance in multiple sclerosis patients
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Fisioterapia em Movimento |
Texto Completo: | https://periodicos.pucpr.br/fisio/article/view/23080 |
Resumo: | Introduction: Multiple Sclerosis (MS) is a chronic inflammatory disease characterized by infiltration of inflammatory cells on the Central Nervous System (CNS). There is evidence that cumulative DNA damage can contribute to various mechanisms underlying MS lesions. Changes in postural balance are frequent observations in subjects with MS. Objective: Evaluated the DNA damage index (DDI)) and postural balance in patients with MS. Methods: A case-control study was conducted with 28 subjects matched for sex, age, and body mass index, divided into MS group and control. The DDI was assessed by comet assay and postural balance through recording the body oscillations of the center of pressure (COP), in the anterior-posterior and lateral middle directions. Results: Showed higher DDI in MS patients (21.3 ± 4.8) than controls (7.9 ± 6.1). Significant differences between groups were also noted in postural control parameters. The wider ranges of postural sway were observed in the MS group. The associations between DDI and postural control parameters showed weak, but significant correlations. No associations were found between DDI and time of diagnosis of MS. Conclusion: People with MS had higher DDI and larger body oscillations than healthy individuals. |
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Fisioterapia em Movimento |
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DNA damage and postural balance in multiple sclerosis patientsIntroduction: Multiple Sclerosis (MS) is a chronic inflammatory disease characterized by infiltration of inflammatory cells on the Central Nervous System (CNS). There is evidence that cumulative DNA damage can contribute to various mechanisms underlying MS lesions. Changes in postural balance are frequent observations in subjects with MS. Objective: Evaluated the DNA damage index (DDI)) and postural balance in patients with MS. Methods: A case-control study was conducted with 28 subjects matched for sex, age, and body mass index, divided into MS group and control. The DDI was assessed by comet assay and postural balance through recording the body oscillations of the center of pressure (COP), in the anterior-posterior and lateral middle directions. Results: Showed higher DDI in MS patients (21.3 ± 4.8) than controls (7.9 ± 6.1). Significant differences between groups were also noted in postural control parameters. The wider ranges of postural sway were observed in the MS group. The associations between DDI and postural control parameters showed weak, but significant correlations. No associations were found between DDI and time of diagnosis of MS. Conclusion: People with MS had higher DDI and larger body oscillations than healthy individuals.Editora PUCPRESS2017-11-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.pucpr.br/fisio/article/view/2308010.1590/1980-5918.030.S01.AO08Fisioterapia em Movimento (Physical Therapy in Movement); Vol. 30 (2017): Suppl 1Fisioterapia em Movimento; v. 30 (2017): Suppl 11980-5918reponame:Fisioterapia em Movimentoinstname:Pontifícia Universidade Católica do Paraná (PUC-PR)instacron:PUC_PRenghttps://periodicos.pucpr.br/fisio/article/view/23080/pdfCopyright (c) 2022 PUCPRESSinfo:eu-repo/semantics/openAccessMendonça Menezes, KarlaDoeler Algarve, ThaísSaraiva Flôres, FábioCruz, Ivana Beatrice MânicaCopetti, FernandoFerreira Silveira, Aron2022-03-07T19:02:06Zoai:ojs.periodicos.pucpr.br:article/23080Revistahttps://periodicos.pucpr.br/fisioPRIhttps://periodicos.pucpr.br/fisio/oairubia.farias@pucpr.br||revista.fisioterapia@pucpr.br1980-59180103-5150opendoar:2022-03-07T19:02:06Fisioterapia em Movimento - Pontifícia Universidade Católica do Paraná (PUC-PR)false |
dc.title.none.fl_str_mv |
DNA damage and postural balance in multiple sclerosis patients |
title |
DNA damage and postural balance in multiple sclerosis patients |
spellingShingle |
DNA damage and postural balance in multiple sclerosis patients Mendonça Menezes, Karla |
title_short |
DNA damage and postural balance in multiple sclerosis patients |
title_full |
DNA damage and postural balance in multiple sclerosis patients |
title_fullStr |
DNA damage and postural balance in multiple sclerosis patients |
title_full_unstemmed |
DNA damage and postural balance in multiple sclerosis patients |
title_sort |
DNA damage and postural balance in multiple sclerosis patients |
author |
Mendonça Menezes, Karla |
author_facet |
Mendonça Menezes, Karla Doeler Algarve, Thaís Saraiva Flôres, Fábio Cruz, Ivana Beatrice Mânica Copetti, Fernando Ferreira Silveira, Aron |
author_role |
author |
author2 |
Doeler Algarve, Thaís Saraiva Flôres, Fábio Cruz, Ivana Beatrice Mânica Copetti, Fernando Ferreira Silveira, Aron |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Mendonça Menezes, Karla Doeler Algarve, Thaís Saraiva Flôres, Fábio Cruz, Ivana Beatrice Mânica Copetti, Fernando Ferreira Silveira, Aron |
description |
Introduction: Multiple Sclerosis (MS) is a chronic inflammatory disease characterized by infiltration of inflammatory cells on the Central Nervous System (CNS). There is evidence that cumulative DNA damage can contribute to various mechanisms underlying MS lesions. Changes in postural balance are frequent observations in subjects with MS. Objective: Evaluated the DNA damage index (DDI)) and postural balance in patients with MS. Methods: A case-control study was conducted with 28 subjects matched for sex, age, and body mass index, divided into MS group and control. The DDI was assessed by comet assay and postural balance through recording the body oscillations of the center of pressure (COP), in the anterior-posterior and lateral middle directions. Results: Showed higher DDI in MS patients (21.3 ± 4.8) than controls (7.9 ± 6.1). Significant differences between groups were also noted in postural control parameters. The wider ranges of postural sway were observed in the MS group. The associations between DDI and postural control parameters showed weak, but significant correlations. No associations were found between DDI and time of diagnosis of MS. Conclusion: People with MS had higher DDI and larger body oscillations than healthy individuals. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.pucpr.br/fisio/article/view/23080 10.1590/1980-5918.030.S01.AO08 |
url |
https://periodicos.pucpr.br/fisio/article/view/23080 |
identifier_str_mv |
10.1590/1980-5918.030.S01.AO08 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.pucpr.br/fisio/article/view/23080/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 PUCPRESS info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 PUCPRESS |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora PUCPRESS |
publisher.none.fl_str_mv |
Editora PUCPRESS |
dc.source.none.fl_str_mv |
Fisioterapia em Movimento (Physical Therapy in Movement); Vol. 30 (2017): Suppl 1 Fisioterapia em Movimento; v. 30 (2017): Suppl 1 1980-5918 reponame:Fisioterapia em Movimento instname:Pontifícia Universidade Católica do Paraná (PUC-PR) instacron:PUC_PR |
instname_str |
Pontifícia Universidade Católica do Paraná (PUC-PR) |
instacron_str |
PUC_PR |
institution |
PUC_PR |
reponame_str |
Fisioterapia em Movimento |
collection |
Fisioterapia em Movimento |
repository.name.fl_str_mv |
Fisioterapia em Movimento - Pontifícia Universidade Católica do Paraná (PUC-PR) |
repository.mail.fl_str_mv |
rubia.farias@pucpr.br||revista.fisioterapia@pucpr.br |
_version_ |
1799138748455190528 |