Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review

• Autor(a) principal: Souza Padilha, Camila
• Data de Publicação: 2017
• Outros Autores: Sanches Cella, Paola, Rodrigues Salles, Leo, Deminice, Rafael
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Fisioterapia em Movimento
• Texto Completo: https://periodicos.pucpr.br/fisio/article/view/22686

Introduction: Recent studies have pointing creatine supplementation as a promising therapeutic alternativein several diseases, especially myopathies and neurodegenerative disorder. Objective: elucidate therole of creatine supplementation on deleterious effect caused by limb immobilization in humans and rats.Methods: Analyzed articles were searched by three online databases, PubMed, SportDicus e Scielo. After areview and analysis, the studies were included in this review articles on effect of creatine supplementationon skeletal muscle in humans and rat, before, during and after a period of limb immobilization. Results:Studies analyzed demonstrated positive points in use of creatine supplementation as a therapeutic tool tomitigating the deleterious effects of limb immobilization, in humans and rat. Conclusion: The dataset ofthis literature review allows us to conclude that creatine supplementation may reduce muscle loss and/orassist in the recovery of muscle atrophy caused by immobilization and disuse in rats and humans. Also, wenote that further research with better methodological rigor is needed to clarify the mechanisms by whichcreatine support the recovery of muscle atrophy. Moreover, these effects are positive and promising in thefield of muscle rehabilitation, especially after member’s immobilization.