Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Fisioterapia em Movimento |
Texto Completo: | https://periodicos.pucpr.br/fisio/article/view/21891 |
Resumo: | Introduction: COPD presents decrease in oxidative metabolism with possible losses of cardiovascular adjustments, suggesting slow kinetics microvascular oxygen during intense exercise. Objective: To test the hypothesis that chronic obstructive pulmonary disease (COPD) patients have lower muscle performance in physical exercise not dependent on central factors, but also greater muscle oxygen extraction, regardless of muscle mass. Methods: Cross-sectional study with 11 COPD patients and nine ealthy subjects, male, paired for age. Spirometry and body composition by DEXA were evaluated. Muscular performance was assessed by maximal voluntary isometric contraction (MVIC) in isokinetic dynamometer and muscle oxygen extraction by the NIRS technique. Student t-test and Pearson correlation were applied. A significance level of p<0.05 was adopted. Results: Patients had moderate to severe COPD (FEV1 = 44.5 ± 9.6% predicted; SpO2 = 94.6 ± 1.6%). Lean leg mass was 8.3 ± 0.9 vs. 8.9 ± 1.0 kg (p =0.033), when comparing COPD and control patients, respectively. The decreased muscle oxygen saturation corrected by muscle mass was 53.2% higher (p=0.044) in the COPD group in MVIC-1 and 149.6% higher (p=0.006) in the MVIC-2. Microvascular extraction rate of oxygen corrected by muscle mass and total work was found to be 114.5% higher (p=0.043) in the COPD group in MVIC-1 and 210.5% higher (p=0.015) in the MVIC-2. Conclusion: COPD patients have low muscle performance and high oxygen extraction per muscle mass unit and per unit of work. The high oxygen extraction suggests that quantitative and qualitative mechanisms can be determinants of muscle performance in patients with COPD. |
id |
PUC_PR-26_ed5dc2c461feef7b1d7a70ce01ff0475 |
---|---|
oai_identifier_str |
oai:ojs.periodicos.pucpr.br:article/21891 |
network_acronym_str |
PUC_PR-26 |
network_name_str |
Fisioterapia em Movimento |
repository_id_str |
|
spelling |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary diseaseIntroduction: COPD presents decrease in oxidative metabolism with possible losses of cardiovascular adjustments, suggesting slow kinetics microvascular oxygen during intense exercise. Objective: To test the hypothesis that chronic obstructive pulmonary disease (COPD) patients have lower muscle performance in physical exercise not dependent on central factors, but also greater muscle oxygen extraction, regardless of muscle mass. Methods: Cross-sectional study with 11 COPD patients and nine ealthy subjects, male, paired for age. Spirometry and body composition by DEXA were evaluated. Muscular performance was assessed by maximal voluntary isometric contraction (MVIC) in isokinetic dynamometer and muscle oxygen extraction by the NIRS technique. Student t-test and Pearson correlation were applied. A significance level of p<0.05 was adopted. Results: Patients had moderate to severe COPD (FEV1 = 44.5 ± 9.6% predicted; SpO2 = 94.6 ± 1.6%). Lean leg mass was 8.3 ± 0.9 vs. 8.9 ± 1.0 kg (p =0.033), when comparing COPD and control patients, respectively. The decreased muscle oxygen saturation corrected by muscle mass was 53.2% higher (p=0.044) in the COPD group in MVIC-1 and 149.6% higher (p=0.006) in the MVIC-2. Microvascular extraction rate of oxygen corrected by muscle mass and total work was found to be 114.5% higher (p=0.043) in the COPD group in MVIC-1 and 210.5% higher (p=0.015) in the MVIC-2. Conclusion: COPD patients have low muscle performance and high oxygen extraction per muscle mass unit and per unit of work. The high oxygen extraction suggests that quantitative and qualitative mechanisms can be determinants of muscle performance in patients with COPD.Editora PUCPRESS2017-09-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.pucpr.br/fisio/article/view/2189110.1590/1980-5918.029.004.AO16Fisioterapia em Movimento (Physical Therapy in Movement); Vol. 29 No. 4 (2016)Fisioterapia em Movimento; v. 29 n. 4 (2016)1980-5918reponame:Fisioterapia em Movimentoinstname:Pontifícia Universidade Católica do Paraná (PUC-PR)instacron:PUC_PRenghttps://periodicos.pucpr.br/fisio/article/view/21891/21026Copyright (c) 2022 PUCPRESSinfo:eu-repo/semantics/openAccessManfredi de Freitas, Flavia FernandesPaiva de Azevedo, DiegoMusetti Medeiros, WladimirNeder, José AlbertoDias Chiavegato, LucianaFerreira Amorim, Cesar2022-03-07T19:01:50Zoai:ojs.periodicos.pucpr.br:article/21891Revistahttps://periodicos.pucpr.br/fisioPRIhttps://periodicos.pucpr.br/fisio/oairubia.farias@pucpr.br||revista.fisioterapia@pucpr.br1980-59180103-5150opendoar:2022-03-07T19:01:50Fisioterapia em Movimento - Pontifícia Universidade Católica do Paraná (PUC-PR)false |
dc.title.none.fl_str_mv |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease |
title |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease |
spellingShingle |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease Manfredi de Freitas, Flavia Fernandes |
title_short |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease |
title_full |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease |
title_fullStr |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease |
title_full_unstemmed |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease |
title_sort |
Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease |
author |
Manfredi de Freitas, Flavia Fernandes |
author_facet |
Manfredi de Freitas, Flavia Fernandes Paiva de Azevedo, Diego Musetti Medeiros, Wladimir Neder, José Alberto Dias Chiavegato, Luciana Ferreira Amorim, Cesar |
author_role |
author |
author2 |
Paiva de Azevedo, Diego Musetti Medeiros, Wladimir Neder, José Alberto Dias Chiavegato, Luciana Ferreira Amorim, Cesar |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Manfredi de Freitas, Flavia Fernandes Paiva de Azevedo, Diego Musetti Medeiros, Wladimir Neder, José Alberto Dias Chiavegato, Luciana Ferreira Amorim, Cesar |
description |
Introduction: COPD presents decrease in oxidative metabolism with possible losses of cardiovascular adjustments, suggesting slow kinetics microvascular oxygen during intense exercise. Objective: To test the hypothesis that chronic obstructive pulmonary disease (COPD) patients have lower muscle performance in physical exercise not dependent on central factors, but also greater muscle oxygen extraction, regardless of muscle mass. Methods: Cross-sectional study with 11 COPD patients and nine ealthy subjects, male, paired for age. Spirometry and body composition by DEXA were evaluated. Muscular performance was assessed by maximal voluntary isometric contraction (MVIC) in isokinetic dynamometer and muscle oxygen extraction by the NIRS technique. Student t-test and Pearson correlation were applied. A significance level of p<0.05 was adopted. Results: Patients had moderate to severe COPD (FEV1 = 44.5 ± 9.6% predicted; SpO2 = 94.6 ± 1.6%). Lean leg mass was 8.3 ± 0.9 vs. 8.9 ± 1.0 kg (p =0.033), when comparing COPD and control patients, respectively. The decreased muscle oxygen saturation corrected by muscle mass was 53.2% higher (p=0.044) in the COPD group in MVIC-1 and 149.6% higher (p=0.006) in the MVIC-2. Microvascular extraction rate of oxygen corrected by muscle mass and total work was found to be 114.5% higher (p=0.043) in the COPD group in MVIC-1 and 210.5% higher (p=0.015) in the MVIC-2. Conclusion: COPD patients have low muscle performance and high oxygen extraction per muscle mass unit and per unit of work. The high oxygen extraction suggests that quantitative and qualitative mechanisms can be determinants of muscle performance in patients with COPD. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.pucpr.br/fisio/article/view/21891 10.1590/1980-5918.029.004.AO16 |
url |
https://periodicos.pucpr.br/fisio/article/view/21891 |
identifier_str_mv |
10.1590/1980-5918.029.004.AO16 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.pucpr.br/fisio/article/view/21891/21026 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 PUCPRESS info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 PUCPRESS |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora PUCPRESS |
publisher.none.fl_str_mv |
Editora PUCPRESS |
dc.source.none.fl_str_mv |
Fisioterapia em Movimento (Physical Therapy in Movement); Vol. 29 No. 4 (2016) Fisioterapia em Movimento; v. 29 n. 4 (2016) 1980-5918 reponame:Fisioterapia em Movimento instname:Pontifícia Universidade Católica do Paraná (PUC-PR) instacron:PUC_PR |
instname_str |
Pontifícia Universidade Católica do Paraná (PUC-PR) |
instacron_str |
PUC_PR |
institution |
PUC_PR |
reponame_str |
Fisioterapia em Movimento |
collection |
Fisioterapia em Movimento |
repository.name.fl_str_mv |
Fisioterapia em Movimento - Pontifícia Universidade Católica do Paraná (PUC-PR) |
repository.mail.fl_str_mv |
rubia.farias@pucpr.br||revista.fisioterapia@pucpr.br |
_version_ |
1799138748056731648 |