Malignant potential of oral lichen planus: A meta-analysis

Detalhes bibliográficos
Autor(a) principal: Sousa, Fernando Augusto Cervantes Garcia de
Data de Publicação: 2009
Outros Autores: Paradella, Thaís Cachuté
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista odonto ciência (Online)
Texto Completo: https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4337
Resumo: Purpose: Several studies have pointed out the malignant transformation potential of oral lichen planus, yet the findings are controversial. The aim of this study was to evaluate the malignant transformation rate of oral lichen planus. Methods: An electronic search of the literature was performed in the PubMed MEDLINE database using the descriptors “oral lichen planus” and “malignant transformation” from January 1988 to September 2008. Ninety-five articles were retrieved and assessed for inclusion. Only prospective and retrospective studies that reported the oral lichen planus malignant transformation rates were considered, as well as studies that included the number of cases with clear criteria for diagnosis of the disease. From the 24 selected studies, information on clinical presentation and location of the lesions, and subjects’ gender and age were recorded. Results: From a total of 11,225 cases of oral lichen planus, 183 (1.63%) developed malignant transformation approximately 6 years after the initial diagnosis. The reticular form was the most common clinical presentation, and the jugal mucosa and tongue were the most frequent locations. However, only the clinical presentation of the disease (atypical forms: atrophic, erosive, “in plaque”) and the location of the lesion (tongue) were associated with a higher malignant transformation risk. Conclusion: Epidemiological studies from the last 20 years revealed a malignant transformation rate of 0.27% per year, emphasizing the importance of the clinical follow-up of oral lichen planus patients.
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spelling Malignant potential of oral lichen planus: A meta-analysisPotencial de transformação maligna do líquen plano bucal: uma meta-análiseOral lichen planusoral cancermeta-analysisOral cancerPurpose: Several studies have pointed out the malignant transformation potential of oral lichen planus, yet the findings are controversial. The aim of this study was to evaluate the malignant transformation rate of oral lichen planus. Methods: An electronic search of the literature was performed in the PubMed MEDLINE database using the descriptors “oral lichen planus” and “malignant transformation” from January 1988 to September 2008. Ninety-five articles were retrieved and assessed for inclusion. Only prospective and retrospective studies that reported the oral lichen planus malignant transformation rates were considered, as well as studies that included the number of cases with clear criteria for diagnosis of the disease. From the 24 selected studies, information on clinical presentation and location of the lesions, and subjects’ gender and age were recorded. Results: From a total of 11,225 cases of oral lichen planus, 183 (1.63%) developed malignant transformation approximately 6 years after the initial diagnosis. The reticular form was the most common clinical presentation, and the jugal mucosa and tongue were the most frequent locations. However, only the clinical presentation of the disease (atypical forms: atrophic, erosive, “in plaque”) and the location of the lesion (tongue) were associated with a higher malignant transformation risk. Conclusion: Epidemiological studies from the last 20 years revealed a malignant transformation rate of 0.27% per year, emphasizing the importance of the clinical follow-up of oral lichen planus patients.Objetivo: Diversos estudos relatam o potencial de transformação maligna do líquen plano bucal, mas os achados são controversos. O objetivo deste estudo foi avaliar a taxa de transformação maligna do líquen plano bucal. Metodologia: Realizou-se uma busca eletrônica da literatura na base de dados PubMed MEDLINE usando os descritores “oral lichen planus” e “malignant transformation”, de janeiro de 1988 a setembro de 2008. Um total de 95 artigos foi obtido, os quais foram avaliados para inclusão. Foram incluídos somente estudos prospectivos e retrospectivos com relato de taxa de transformação maligna de líquen plano bucal, bem como estudos com o número de casos com critérios de diagnóstico para a doença. Dos 24 estudos selecionados, os dados coletados incluíram apresentação clínica e localização anatômica das lesões e idade e gênero dos sujeitos. Resultados: De um total de 11.225 casos de líquen plano bucal, 183 (1,63%) desenvolveram transformação maligna aproximadamente seis anos após o diagnóstico inicial. A forma reticular foi a apresentação clínica mais frequente e a mucosa jugal e lingual as localização mais freqüentes das lesões. Entretanto, somente a apresentação clínica (formas atípicas: atrófica, erosiva, “em placa”) e a localização da lesão (língua) foram associados a maior risco de transformação maligna. Conclusão: Estudos epidemiológicos realizados nos últimos 20 anos revelaram uma taxa de transformação maligna de 0,27% ao ano para o líquen plano bucal, o que enfatiza a importância do acompanhamento clínicos destes pacientes.EDIPUCRS - Editora Universitária da PUCRS2009-02-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article. Invited Article.meta-analysis; reviewapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4337Revista Odonto Ciência; Vol. 24 No. 2 (2009); 194 - 197Revista Odonto Ciência; v. 24 n. 2 (2009); 194 - 1971980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4337/3987Sousa, Fernando Augusto Cervantes Garcia deParadella, Thaís Cachutéinfo:eu-repo/semantics/openAccess2013-11-11T13:15:30Zoai:ojs.revistaseletronicas.pucrs.br:article/4337Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T13:15:30Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Malignant potential of oral lichen planus: A meta-analysis
Potencial de transformação maligna do líquen plano bucal: uma meta-análise
title Malignant potential of oral lichen planus: A meta-analysis
spellingShingle Malignant potential of oral lichen planus: A meta-analysis
Sousa, Fernando Augusto Cervantes Garcia de
Oral lichen planus
oral cancer
meta-analysis
Oral cancer
title_short Malignant potential of oral lichen planus: A meta-analysis
title_full Malignant potential of oral lichen planus: A meta-analysis
title_fullStr Malignant potential of oral lichen planus: A meta-analysis
title_full_unstemmed Malignant potential of oral lichen planus: A meta-analysis
title_sort Malignant potential of oral lichen planus: A meta-analysis
author Sousa, Fernando Augusto Cervantes Garcia de
author_facet Sousa, Fernando Augusto Cervantes Garcia de
Paradella, Thaís Cachuté
author_role author
author2 Paradella, Thaís Cachuté
author2_role author
dc.contributor.author.fl_str_mv Sousa, Fernando Augusto Cervantes Garcia de
Paradella, Thaís Cachuté
dc.subject.por.fl_str_mv Oral lichen planus
oral cancer
meta-analysis
Oral cancer
topic Oral lichen planus
oral cancer
meta-analysis
Oral cancer
description Purpose: Several studies have pointed out the malignant transformation potential of oral lichen planus, yet the findings are controversial. The aim of this study was to evaluate the malignant transformation rate of oral lichen planus. Methods: An electronic search of the literature was performed in the PubMed MEDLINE database using the descriptors “oral lichen planus” and “malignant transformation” from January 1988 to September 2008. Ninety-five articles were retrieved and assessed for inclusion. Only prospective and retrospective studies that reported the oral lichen planus malignant transformation rates were considered, as well as studies that included the number of cases with clear criteria for diagnosis of the disease. From the 24 selected studies, information on clinical presentation and location of the lesions, and subjects’ gender and age were recorded. Results: From a total of 11,225 cases of oral lichen planus, 183 (1.63%) developed malignant transformation approximately 6 years after the initial diagnosis. The reticular form was the most common clinical presentation, and the jugal mucosa and tongue were the most frequent locations. However, only the clinical presentation of the disease (atypical forms: atrophic, erosive, “in plaque”) and the location of the lesion (tongue) were associated with a higher malignant transformation risk. Conclusion: Epidemiological studies from the last 20 years revealed a malignant transformation rate of 0.27% per year, emphasizing the importance of the clinical follow-up of oral lichen planus patients.
publishDate 2009
dc.date.none.fl_str_mv 2009-02-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article. Invited Article.
meta-analysis; review
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4337
url https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4337
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4337/3987
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
dc.source.none.fl_str_mv Revista Odonto Ciência; Vol. 24 No. 2 (2009); 194 - 197
Revista Odonto Ciência; v. 24 n. 2 (2009); 194 - 197
1980-6523
0102-9460
reponame:Revista odonto ciência (Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Revista odonto ciência (Online)
collection Revista odonto ciência (Online)
repository.name.fl_str_mv Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv ||odontociencia@pucrs.br
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