The impact of chronic stress on behavior in rats with ligature-induced periodontal disease

• Autor(a) principal: Porto, Alessandra Nogueira
• Data de Publicação: 2012
• Outros Autores: Segundo, Alex Semenoff, Borges, Álvaro Henrique, Miranda Pedro, Fábio Luis, Matos, Fernanda Zamol, Semenoff, Tereza Aparecida Dele Vedove
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista odonto ciência (Online)
• Texto Completo: https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/11882
• topic: stress; rats; periodontitis.; Doença periodontal; stress

 Purpose: To evaluate the impact of chronic stress on behavior at different time points (7, 15 and 30 days) in rats with ligature-induced periodontal disease. Methods: We selected 60 rats that were randomly divided into 2 groups: a stress group subjected to chronic stress by physical restraint one day after periodontitis induction (GE) and a control group (CG). After periods 10 animals from the GE group and 10 from the CG were analyzed in the open field and elevated plus-maze models.Results: The results show that at 7 days, increased walk in the central segment of the apparatus and peripheral open field (P<0.05) were observed in the GE group as well as increased instances of standing on two legs and self-cleaning (P<0.05). In the elevated plus-maze, no statistical differences were observed (P<0.05). At the 15-day time point, increased instances of standing on two legs and self-cleaning (P<0.05) were observed in the GE group. At 30 days, no behavioral differences were observed between the groups (P<0.05). Conclusion: We conclude that stress affect the behavior of animals subjected to 7 and 15 days of chronic stress after the induction of periodontal disease by ligation.