Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista odonto ciência (Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621 |
Resumo: | The objective of this literature review is to discuss the influence of immunosuppressants on bone metabolism and tooth movement in Orthodontics. Tooth movement occurs as a result of bone and periodontal ligament remodeling. Some medications such as immunosupressants can affect bone metabolism and the rate of tooth movement. Immunosupressants act by repressing the action of T lymphocytes, may cause bone loss, and lead to osteoporosis, which is a common complication following kidney, heart, liver, or lung transplantation. The use of immunosuppressants to prevent rejection after organ transplantation includes glucocorticoids, cyclosporine A, tacrolimus, and sirolimus, which may cause damaging effects on the bone mineral homeostasis. Tooth movement depends on orthodontic force, dosage, and duration of immunosuppressive therapy, and individual response of each patient. Therefore, all patients who have received transplants should be closely monitored to prevent bone loss before and during orthodontic treatment. Key words: Immunosuppressant; tooth movement; bone |
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Influence of immunosuppressants on bone metabolism and tooth movement: A literature reviewInfluência dos imunossupressores no metabolismo ósseo e movimento dentário: revisão de literaturaImmunosuppressanttooth movementboneTooth movementThe objective of this literature review is to discuss the influence of immunosuppressants on bone metabolism and tooth movement in Orthodontics. Tooth movement occurs as a result of bone and periodontal ligament remodeling. Some medications such as immunosupressants can affect bone metabolism and the rate of tooth movement. Immunosupressants act by repressing the action of T lymphocytes, may cause bone loss, and lead to osteoporosis, which is a common complication following kidney, heart, liver, or lung transplantation. The use of immunosuppressants to prevent rejection after organ transplantation includes glucocorticoids, cyclosporine A, tacrolimus, and sirolimus, which may cause damaging effects on the bone mineral homeostasis. Tooth movement depends on orthodontic force, dosage, and duration of immunosuppressive therapy, and individual response of each patient. Therefore, all patients who have received transplants should be closely monitored to prevent bone loss before and during orthodontic treatment. Key words: Immunosuppressant; tooth movement; boneO objetivo desta revisão de literatura é discutir a influência dos imunossupressores no metabolismo ósseo e movimento dentário em Ortodontia. O movimento dentário ocorre em função do processo de remodelação do tecido ósseo e do ligamento periodontal. Existem medicamentos capazes de afetar o metabolismo ósseo e a taxa de movimento dentário, tais como os imunossupressores. Os imunossupressores agem reprimindo a ação dos linfócitos T, podem causar perda óssea e levar a um quadro de osteoporose, a qual é uma complicação comum após os transplantes de rim, coração, fígado e pulmão. Os esquemas imunossupressores para evitar a rejeição do órgão enxertado após o transplante frequentemente incluem glicocorticóides, ciclosporina A, tacrolimus e sirolimus, os quais podem causar efeitos danosos sobre a homeostase mineral óssea. O movimento dentário é dependente da força ortodôntica, dose e duração da terapia imunossupressora, além da resposta individual de cada indivíduo. Assim, todos os pacientes transplantados e usuários de imunossupressores deveriam ser submetidos a monitoramento e prevenção de perda óssea antes e durante o tratamento ortodôntico. Palavras-chave: Imunossupressor; movimento dentário; ossoEDIPUCRS - Editora Universitária da PUCRS2008-08-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article. Invited Article.literature reviewapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621Revista Odonto Ciência; Vol. 24 No. 1 (2009); 86 - 91Revista Odonto Ciência; v. 24 n. 1 (2009); 86 - 911980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621/3676Santos, Rogério Lacerda dosGonçalves, Renato TorresMartins, Marco AurélioSouza, Margareth Maria Gomes deinfo:eu-repo/semantics/openAccess2013-11-11T13:23:40Zoai:ojs.revistaseletronicas.pucrs.br:article/3621Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T13:23:40Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review Influência dos imunossupressores no metabolismo ósseo e movimento dentário: revisão de literatura |
title |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review |
spellingShingle |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review Santos, Rogério Lacerda dos Immunosuppressant tooth movement bone Tooth movement |
title_short |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review |
title_full |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review |
title_fullStr |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review |
title_full_unstemmed |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review |
title_sort |
Influence of immunosuppressants on bone metabolism and tooth movement: A literature review |
author |
Santos, Rogério Lacerda dos |
author_facet |
Santos, Rogério Lacerda dos Gonçalves, Renato Torres Martins, Marco Aurélio Souza, Margareth Maria Gomes de |
author_role |
author |
author2 |
Gonçalves, Renato Torres Martins, Marco Aurélio Souza, Margareth Maria Gomes de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Santos, Rogério Lacerda dos Gonçalves, Renato Torres Martins, Marco Aurélio Souza, Margareth Maria Gomes de |
dc.subject.por.fl_str_mv |
Immunosuppressant tooth movement bone Tooth movement |
topic |
Immunosuppressant tooth movement bone Tooth movement |
description |
The objective of this literature review is to discuss the influence of immunosuppressants on bone metabolism and tooth movement in Orthodontics. Tooth movement occurs as a result of bone and periodontal ligament remodeling. Some medications such as immunosupressants can affect bone metabolism and the rate of tooth movement. Immunosupressants act by repressing the action of T lymphocytes, may cause bone loss, and lead to osteoporosis, which is a common complication following kidney, heart, liver, or lung transplantation. The use of immunosuppressants to prevent rejection after organ transplantation includes glucocorticoids, cyclosporine A, tacrolimus, and sirolimus, which may cause damaging effects on the bone mineral homeostasis. Tooth movement depends on orthodontic force, dosage, and duration of immunosuppressive therapy, and individual response of each patient. Therefore, all patients who have received transplants should be closely monitored to prevent bone loss before and during orthodontic treatment. Key words: Immunosuppressant; tooth movement; bone |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article. Invited Article. literature review |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621 |
url |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621/3676 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
dc.source.none.fl_str_mv |
Revista Odonto Ciência; Vol. 24 No. 1 (2009); 86 - 91 Revista Odonto Ciência; v. 24 n. 1 (2009); 86 - 91 1980-6523 0102-9460 reponame:Revista odonto ciência (Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Revista odonto ciência (Online) |
collection |
Revista odonto ciência (Online) |
repository.name.fl_str_mv |
Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
||odontociencia@pucrs.br |
_version_ |
1754820874305798144 |