Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista odonto ciência (Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4696 |
Resumo: | Dental caries may be defined as a complex multifatorial disease in that a broad group of biological, socio-economic and cultural factors interact directly or indirectly in the establishment and colonization of cariogenic microorganisms within the microbial community of the dental biofilm. Innate and adaptative immunity are two fundamental aspects of the immune system response against infections, such as dental caries. Besides, the majority of pathogenic infectious agents enter the organisms by the oral route. Consequently, the mucosal tissue, associated exocrine glands and saliva contributes to the protection of the oral cavity because contain cells responsible for antigen internalization and antibodies specific to oral bacteria. Macrophages are phagocytic cells that can internalize and kill bacteria by several mechanisms of internalization, including endocytosis, macropinocytosis and phagocytosis. Streptococcus mutans is the major pathogen of dental caries due to its ability to adhere and accumulate on tooth surfaces, using different virulence factors (AgI/II, Gtf, Gbps). Recent studies demonstrated protection against experimentally induced dental caries for vaccines containing intact or peptides from antigen I/II, Gtf or Gbp and vaccines containing a combination of antigens. The present review summarizes the fundamental mechanisms of host immune responses to oral bacteria and the main perspectives of a vaccine against dental caries |
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Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief reviewMecanismos fundamentais de resposta imune contra bactérias bucais e as principais perspectivas para uma vacina anticárie: uma breve revisãodental cariesvaccinedental cariesDental caries may be defined as a complex multifatorial disease in that a broad group of biological, socio-economic and cultural factors interact directly or indirectly in the establishment and colonization of cariogenic microorganisms within the microbial community of the dental biofilm. Innate and adaptative immunity are two fundamental aspects of the immune system response against infections, such as dental caries. Besides, the majority of pathogenic infectious agents enter the organisms by the oral route. Consequently, the mucosal tissue, associated exocrine glands and saliva contributes to the protection of the oral cavity because contain cells responsible for antigen internalization and antibodies specific to oral bacteria. Macrophages are phagocytic cells that can internalize and kill bacteria by several mechanisms of internalization, including endocytosis, macropinocytosis and phagocytosis. Streptococcus mutans is the major pathogen of dental caries due to its ability to adhere and accumulate on tooth surfaces, using different virulence factors (AgI/II, Gtf, Gbps). Recent studies demonstrated protection against experimentally induced dental caries for vaccines containing intact or peptides from antigen I/II, Gtf or Gbp and vaccines containing a combination of antigens. The present review summarizes the fundamental mechanisms of host immune responses to oral bacteria and the main perspectives of a vaccine against dental cariesA cárie dentária pode ser definida como uma doença complexa multifatorial causada por fatores biológicos, socioeconômicos e culturais que interagem direta ou indiretamente na colonização e estabelecimento de microrganismos cariogênicos na comunidade microbiana do biofilme dentário. As imunidades inata e adaptativa são os dois aspectos fundamentais de resposta do sistema imune contra infecções, como a cárie dentária. Além disso, a maioria dos agentes infecciosos patogênicos entra no organismo por via oral. Consequentemente, o tecido mucoso, associado com as glândulas exócrinas e a saliva contribuem para a proteção da cavidade bucal por conterem células responsáveis pela internalização de antígenos ou anticorpos contra as bactérias bucais. Os macrófagos são células fagocíticas que podem internalizar e eliminar bactérias por diversos mecanismos de internalização, como a endocitose, macropinocitose e fagocitose. Streptococcus mutans é o principal patógeno da cárie dentária por sua habilidade em aderir e acumular nas superfícies dentárias, usando diferentes fatores de virulência (AgI/II, Gtf e Gbps). Estudos recentes têm demonstrado proteção contra cárie induzida experimentalmente utilizando vacinas contendo antígenos intactos ou peptídeos a partir de AgI/II, Gtf ou Gbps ou uma combinação de antígenos. A presente revisão sumariza os mecanismos fundamentais de resposta imune contra bactérias bucais e as principais perspectivas de uma vacina anticárie.EDIPUCRS - Editora Universitária da PUCRS2009-03-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article. Invited Article.info:eu-repo/semantics/otherapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4696Revista Odonto Ciência; Vol. 24 No. 2 (2009); 198 - 204Revista Odonto Ciência; v. 24 n. 2 (2009); 198 - 2041980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4696/3989Negrini, Thais de CássiaDuque, CristianeHöfling, José FranciscoGonçalves, Reginaldo Brunoinfo:eu-repo/semantics/openAccess2013-11-11T13:15:30Zoai:ojs.revistaseletronicas.pucrs.br:article/4696Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T13:15:30Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review Mecanismos fundamentais de resposta imune contra bactérias bucais e as principais perspectivas para uma vacina anticárie: uma breve revisão |
title |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review |
spellingShingle |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review Negrini, Thais de Cássia dental caries vaccine dental caries |
title_short |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review |
title_full |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review |
title_fullStr |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review |
title_full_unstemmed |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review |
title_sort |
Fundamental mechanisms of immune response to oral bacteria and the main perspectives of a vaccine against dental caries: A brief review |
author |
Negrini, Thais de Cássia |
author_facet |
Negrini, Thais de Cássia Duque, Cristiane Höfling, José Francisco Gonçalves, Reginaldo Bruno |
author_role |
author |
author2 |
Duque, Cristiane Höfling, José Francisco Gonçalves, Reginaldo Bruno |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Negrini, Thais de Cássia Duque, Cristiane Höfling, José Francisco Gonçalves, Reginaldo Bruno |
dc.subject.por.fl_str_mv |
dental caries vaccine dental caries |
topic |
dental caries vaccine dental caries |
description |
Dental caries may be defined as a complex multifatorial disease in that a broad group of biological, socio-economic and cultural factors interact directly or indirectly in the establishment and colonization of cariogenic microorganisms within the microbial community of the dental biofilm. Innate and adaptative immunity are two fundamental aspects of the immune system response against infections, such as dental caries. Besides, the majority of pathogenic infectious agents enter the organisms by the oral route. Consequently, the mucosal tissue, associated exocrine glands and saliva contributes to the protection of the oral cavity because contain cells responsible for antigen internalization and antibodies specific to oral bacteria. Macrophages are phagocytic cells that can internalize and kill bacteria by several mechanisms of internalization, including endocytosis, macropinocytosis and phagocytosis. Streptococcus mutans is the major pathogen of dental caries due to its ability to adhere and accumulate on tooth surfaces, using different virulence factors (AgI/II, Gtf, Gbps). Recent studies demonstrated protection against experimentally induced dental caries for vaccines containing intact or peptides from antigen I/II, Gtf or Gbp and vaccines containing a combination of antigens. The present review summarizes the fundamental mechanisms of host immune responses to oral bacteria and the main perspectives of a vaccine against dental caries |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-03-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article. Invited Article. info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4696 |
url |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4696 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4696/3989 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
dc.source.none.fl_str_mv |
Revista Odonto Ciência; Vol. 24 No. 2 (2009); 198 - 204 Revista Odonto Ciência; v. 24 n. 2 (2009); 198 - 204 1980-6523 0102-9460 reponame:Revista odonto ciência (Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Revista odonto ciência (Online) |
collection |
Revista odonto ciência (Online) |
repository.name.fl_str_mv |
Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
||odontociencia@pucrs.br |
_version_ |
1754820874825891840 |