Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions

Detalhes bibliográficos
Autor(a) principal: Moraes, Maiara de
Data de Publicação: 2013
Outros Autores: Rodrigues de Matos, Felipe, de Lisboa Lopes Costa, Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista odonto ciência (Online)
Texto Completo: https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/12184
Resumo: Receptor activator of nuclear factor κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are members of the superfamily of ligands and receptors of tumor necrosis factor relationed with bone metabolism. Osteoclastogenesis is regulated by these three proteins. The aim of this review was to assess the immunohistochemical expression of these proteins in osteolytic jaws lesions. Studies were identified by searching MEDLINE/Pubmed. The results link higher imunoexpression for RANKL compared to OPG in chronic periodontitis and in aggressive odontogenic tumors, and in less aggressive odontogenic tumors a tendency for higher expression for OPG. Taken into account this, OPG could be a good candidate for the treatment of oral lesions can often be widely destructive.
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spelling Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesionsFatores reguladores da osteoclastogênese (RANK, RANKL e OPG) em lesões osteolíticas da maxilaOsteoclastogenesisRANKLRANKOPGOsteoclastogêneseRANKLRANKOPGReceptor activator of nuclear factor κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are members of the superfamily of ligands and receptors of tumor necrosis factor relationed with bone metabolism. Osteoclastogenesis is regulated by these three proteins. The aim of this review was to assess the immunohistochemical expression of these proteins in osteolytic jaws lesions. Studies were identified by searching MEDLINE/Pubmed. The results link higher imunoexpression for RANKL compared to OPG in chronic periodontitis and in aggressive odontogenic tumors, and in less aggressive odontogenic tumors a tendency for higher expression for OPG. Taken into account this, OPG could be a good candidate for the treatment of oral lesions can often be widely destructive.Receptor activador do factor nuclear kB (RANK), ligante de RANK (RANKL) e osteoprotegerina (OPG), são membros da superfamília de ligantes e receptores do fator de necrose tumoral relacionados com o metabolismo ósseo. A osteoclastogênese é regulada por estas três proteínas. O objetivo desta revisão foi avaliar a expressão imuno-histoquímica destas proteínas em lesões osteolíticas dos maxilares. Os estudos foram identificados através de pesquisa MEDLINE/PubMed. Os resultados revelaram maior imunoexpressão para RANKL em relação a OPG em periodontites crônicas e em tumores odontogênicos agressivos, já em tumores menos agressivos houve uma tendência de maior expressão para OPG. Levando em conta estes achados, a OPG poderia ser um bom candidato para o tratamento de lesões maxilares que podem muitas vezes ser amplamente destrutivas.EDIPUCRS - Editora Universitária da PUCRS2013-10-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article. Invited Article.application/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/12184Revista Odonto Ciência; Vol. 28 No. 2 (2013); 53-57Revista Odonto Ciência; v. 28 n. 2 (2013); 53-571980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/12184/11859Moraes, Maiara deRodrigues de Matos, Felipede Lisboa Lopes Costa, Antonioinfo:eu-repo/semantics/openAccess2014-09-19T18:23:55Zoai:ojs.revistaseletronicas.pucrs.br:article/12184Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2014-09-19T18:23:55Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
Fatores reguladores da osteoclastogênese (RANK, RANKL e OPG) em lesões osteolíticas da maxila
title Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
spellingShingle Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
Moraes, Maiara de
Osteoclastogenesis
RANKL
RANK
OPG
Osteoclastogênese
RANKL
RANK
OPG
title_short Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
title_full Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
title_fullStr Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
title_full_unstemmed Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
title_sort Osteoclastogenesis regulatory factors (RANK, RANKL and OPG) in osteolytic jaw lesions
author Moraes, Maiara de
author_facet Moraes, Maiara de
Rodrigues de Matos, Felipe
de Lisboa Lopes Costa, Antonio
author_role author
author2 Rodrigues de Matos, Felipe
de Lisboa Lopes Costa, Antonio
author2_role author
author
dc.contributor.author.fl_str_mv Moraes, Maiara de
Rodrigues de Matos, Felipe
de Lisboa Lopes Costa, Antonio
dc.subject.por.fl_str_mv Osteoclastogenesis
RANKL
RANK
OPG
Osteoclastogênese
RANKL
RANK
OPG
topic Osteoclastogenesis
RANKL
RANK
OPG
Osteoclastogênese
RANKL
RANK
OPG
description Receptor activator of nuclear factor κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are members of the superfamily of ligands and receptors of tumor necrosis factor relationed with bone metabolism. Osteoclastogenesis is regulated by these three proteins. The aim of this review was to assess the immunohistochemical expression of these proteins in osteolytic jaws lesions. Studies were identified by searching MEDLINE/Pubmed. The results link higher imunoexpression for RANKL compared to OPG in chronic periodontitis and in aggressive odontogenic tumors, and in less aggressive odontogenic tumors a tendency for higher expression for OPG. Taken into account this, OPG could be a good candidate for the treatment of oral lesions can often be widely destructive.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article. Invited Article.
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/12184
url https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/12184
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/12184/11859
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
dc.source.none.fl_str_mv Revista Odonto Ciência; Vol. 28 No. 2 (2013); 53-57
Revista Odonto Ciência; v. 28 n. 2 (2013); 53-57
1980-6523
0102-9460
reponame:Revista odonto ciência (Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Revista odonto ciência (Online)
collection Revista odonto ciência (Online)
repository.name.fl_str_mv Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv ||odontociencia@pucrs.br
_version_ 1754820876398755840

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