Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | PAJAR - Pan American Journal of Aging Research |
Texto Completo: | https://revistaseletronicas.pucrs.br/ojs/index.php/pajar/article/view/32016 |
Resumo: | AimS: Vitamin D is known to be vital in sustaining musculoskeletal functions, with its deficiency may cause muscle weakness and decreased bone mineral density. Vitamin D inadequacy is highly prevalent and its deficiency or insufficiency estimated to affect one billion people worldwide. It causes secondary hyperparathyroidism, bone loss, fractures and it has been associated with a number of other conditions, such as impaired muscle function (1), we decided to verify if there is an association between 25(OH)D status and handgrip strength and with lean muscle mass after cholecalciferol supplementation in elderly women.Methods : We studied fifty-four postmenopausal women with serum 25(OH)D below 30 ng/mL during three months. Cholecalciferol supplementation was divided into two levels according to classification: deficient (10000 units/day) and insufficient (2000 units/day). Changes in biochemical response and in body composition were assessed using dual-x-ray energy absormetry, handgrip strength and blood tests before and after supplementation.Results: The majority of the sample were vitamin D deficient. There was no difference in the deficient group for handgrip strength after the supplementation (p=0,489), but PTH had a statistically significant reduction (p=0.001). Besides, the deficient group had a decrease in lean mass even after the intervention (p=0.006). The results were similar when comparing within results of the insufficient group, however lean mass remained stable (p=0.423).Conclusion: Three-month cholecalciferol supplementation alone in elderly women with doses according to 25(OH)D serum was insufficient to change handgrip strength and total lean muscle mass, however secondary hyperparathyroidism was corrected. |
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Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern BrazilFuerza muscular y masa muscular en mujeres mayores después de suplementación con colecalciferol en el sur de BrasilMuscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern BrazilCholecalciferolMuscle strengthElderly.ColecalciferolFuerza muscularAnciano.CholecalciferolMuscle strengthElderly.AimS: Vitamin D is known to be vital in sustaining musculoskeletal functions, with its deficiency may cause muscle weakness and decreased bone mineral density. Vitamin D inadequacy is highly prevalent and its deficiency or insufficiency estimated to affect one billion people worldwide. It causes secondary hyperparathyroidism, bone loss, fractures and it has been associated with a number of other conditions, such as impaired muscle function (1), we decided to verify if there is an association between 25(OH)D status and handgrip strength and with lean muscle mass after cholecalciferol supplementation in elderly women.Methods : We studied fifty-four postmenopausal women with serum 25(OH)D below 30 ng/mL during three months. Cholecalciferol supplementation was divided into two levels according to classification: deficient (10000 units/day) and insufficient (2000 units/day). Changes in biochemical response and in body composition were assessed using dual-x-ray energy absormetry, handgrip strength and blood tests before and after supplementation.Results: The majority of the sample were vitamin D deficient. There was no difference in the deficient group for handgrip strength after the supplementation (p=0,489), but PTH had a statistically significant reduction (p=0.001). Besides, the deficient group had a decrease in lean mass even after the intervention (p=0.006). The results were similar when comparing within results of the insufficient group, however lean mass remained stable (p=0.423).Conclusion: Three-month cholecalciferol supplementation alone in elderly women with doses according to 25(OH)D serum was insufficient to change handgrip strength and total lean muscle mass, however secondary hyperparathyroidism was corrected.OBJETIVOS: La vitamina D es conocida por ser vital en el mantenimiento de las funciones musculoesqueléticas, su deficiencia puede causar debilidad muscular y disminución de la densidad mineral ósea. La inadecuación de la vitamina D es altamente prevalente y su deficiencia o insuficiencia afecta a mil millones de personas en todo el mundo. Causa hiperparatiroidismo secundario, pérdida ósea, fracturas y viene siendo asociada a una serie de otras condiciones, como la función muscular perjudicada, por eso decidimos verificar si hay una asociación entre 25(OH)D y la fuerza de prensión manual y con masa muscular magra después de suplementación con colecalciferol en mujeres mayores.Métodos: Se estudiaron 55 mujeres en la post menopausia con 25(OH)D sérica debajo de 30 ng/mL durante tres meses. La suplementación de colecalciferol fue dividida en dos niveles según la clasificación: deficiente (1000 unidades/día) e insuficiente (2000 unidades/día). Alteraciones en la respuesta bioquímica y en la composición corporal fueron evaluadas usando la absorciometría de rayos-x de doble energía, fuerza de prensión manual y análisis de sangre antes y después de la suplementación.Resultados: La mayoría de la muestra era deficiente en vitamina D. No hubo diferencia en el grupo con deficiencia para la fuerza de prensión manual después de la suplementación (p=0,489), pero la PTH tuvo reducción estadísticamente significativa (p=0,001). Además, el grupo deficiente presentó disminución de la masa magra aun después de la intervención (p=0,006). Los resultados fueron similares cuando comparados con los resultados del grupo insuficiente, sin embargo la masa magra permaneció estable (p=0,423).Conclusión: La suplementación aislada de colecalciferol por tres meses en mujeres mayores con dosis según los niveles sérico de 25(OH)D fue insuficiente para alterar la fuerza de prensión manual y la masa muscular total, pero el hiperparatiroidismo secundario fue corregido.AimS: Vitamin D is known to be vital in sustaining musculoskeletal functions, with its deficiency may cause muscle weakness and decreased bone mineral density. Vitamin D inadequacy is highly prevalent and its deficiency or insufficiency estimated to affect one billion people worldwide. It causes secondary hyperparathyroidism, bone loss, fractures and it has been associated with a number of other conditions, such as impaired muscle function (1), we decided to verify if there is an association between 25(OH)D status and handgrip strength and with lean muscle mass after cholecalciferol supplementation in elderly women.Methods : We studied fifty-four postmenopausal women with serum 25(OH)D below 30 ng/mL during three months. Cholecalciferol supplementation was divided into two levels according to classification: deficient (10000 units/day) and insufficient (2000 units/day). Changes in biochemical response and in body composition were assessed using dual-x-ray energy absormetry, handgrip strength and blood tests before and after supplementation.Results: The majority of the sample were vitamin D deficient. There was no difference in the deficient group for handgrip strength after the supplementation (p=0,489), but PTH had a statistically significant reduction (p=0.001). Besides, the deficient group had a decrease in lean mass even after the intervention (p=0.006). The results were similar when comparing within results of the insufficient group, however lean mass remained stable (p=0.423).Conclusion: Three-month cholecalciferol supplementation alone in elderly women with doses according to 25(OH)D serum was insufficient to change handgrip strength and total lean muscle mass, however secondary hyperparathyroidism was corrected. *** Força muscular e massa muscular em mulheres idosas após suplementação com colecalciferol no sul do Brasil ***OBJETIVOS: A vitamina D é conhecida por ser vital na manutenção das funções musculoesqueléticas, sua deficiência pode causar fraqueza muscular e diminuição da densidade mineral óssea. A inadequação da vitamina D é altamente prevalente e sua deficiência ou insuficiência estimada afeta um bilhão de pessoas em todo o mundo. Causa hiperparatireoidismo secundário, perda óssea, fraturas e tem sido associada a uma série de outras condições, como função muscular prejudicada, por isso decidimos verificar se há associação entre 25(OH)D e força de preensão manual e com massa muscular magra após suplementação com colecalciferol em mulheres idosas.Métodos : Foram estudadas 55 mulheres na pós-menopausa com 25(OH)D sérica abaixo de 30 ng/mL durante três meses. A suplementação de colecalciferol foi dividida em dois níveis de acordo com a classificação: deficiente (10000 unidades/dia) e insuficiente (2000 unidades/dia). Alterações na resposta bioquímica e na composição corporal foram avaliadas usando a absorciometria de raios-x de dupla energia, força de preensão manual e exames de sangue antes e após a suplementação.Resultados: A maioria da amostra era deficiente em vitamina D. Não houve diferença no grupo com deficiência para força de preensão manual após a suplementação (p=0,489), mas o PTH teve redução estatisticamente significativa (p=0,001). Além disso, o grupo deficiente apresentou diminuição da massa magra mesmo após a intervenção (p=0,006). Os resultados foram semelhantes quando comparados com resultados de grupo insuficiente, porém a massa magra permaneceu estável (p=0,423).Conclusão: A suplementação isolada de colecalciferol por três meses em mulheres idosas com doses de acordo com níveis sérico de 25(OH)D foi insuficiente para alterar a força de preensão manual e a massa muscular total, porém o hiperparatireoidismo secundário foi corrigido.Palavras-chave: Colecalciferol; Força muscular; Idoso.Editora da PUCRS - ediPUCRS2019-06-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/pajar/article/view/3201610.15448/2357-9641.2019.1.32016PAJAR - Pan American Journal of Aging Research; Vol. 7 No. 1 (2019); e32016PAJAR - Pan-American Journal of Aging Research; Vol. 7 Núm. 1 (2019); e32016PAJAR - Pan-American Journal of Aging Research; v. 7 n. 1 (2019); e320162357-964110.15448/2357-9641.2019.1reponame:PAJAR - Pan American Journal of Aging Researchinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUCRSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/pajar/article/view/32016/17941Copyright (c) 2019 PAJAR - Pan-American Journal of Aging Researchinfo:eu-repo/semantics/openAccessda Silva, Patrícia ZamboneSchneider, Rodolfo Herberto2019-08-29T17:43:19Zoai:ojs.revistaseletronicas.pucrs.br:article/32016Revistahttp://revistaseletronicas.pucrs.br/ojs/index.php/pajar/about/editorialTeamPRIhttp://revistaseletronicas.pucrs.br/ojs/index.php/pajar/oaicataldo@pucrs.br||pajar@pucrs.br2357-96412357-9641opendoar:2019-08-29T17:43:19PAJAR - Pan American Journal of Aging Research - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil Fuerza muscular y masa muscular en mujeres mayores después de suplementación con colecalciferol en el sur de Brasil Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil |
title |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil |
spellingShingle |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil da Silva, Patrícia Zambone Cholecalciferol Muscle strength Elderly. Colecalciferol Fuerza muscular Anciano. Cholecalciferol Muscle strength Elderly. |
title_short |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil |
title_full |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil |
title_fullStr |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil |
title_full_unstemmed |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil |
title_sort |
Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil |
author |
da Silva, Patrícia Zambone |
author_facet |
da Silva, Patrícia Zambone Schneider, Rodolfo Herberto |
author_role |
author |
author2 |
Schneider, Rodolfo Herberto |
author2_role |
author |
dc.contributor.author.fl_str_mv |
da Silva, Patrícia Zambone Schneider, Rodolfo Herberto |
dc.subject.por.fl_str_mv |
Cholecalciferol Muscle strength Elderly. Colecalciferol Fuerza muscular Anciano. Cholecalciferol Muscle strength Elderly. |
topic |
Cholecalciferol Muscle strength Elderly. Colecalciferol Fuerza muscular Anciano. Cholecalciferol Muscle strength Elderly. |
description |
AimS: Vitamin D is known to be vital in sustaining musculoskeletal functions, with its deficiency may cause muscle weakness and decreased bone mineral density. Vitamin D inadequacy is highly prevalent and its deficiency or insufficiency estimated to affect one billion people worldwide. It causes secondary hyperparathyroidism, bone loss, fractures and it has been associated with a number of other conditions, such as impaired muscle function (1), we decided to verify if there is an association between 25(OH)D status and handgrip strength and with lean muscle mass after cholecalciferol supplementation in elderly women.Methods : We studied fifty-four postmenopausal women with serum 25(OH)D below 30 ng/mL during three months. Cholecalciferol supplementation was divided into two levels according to classification: deficient (10000 units/day) and insufficient (2000 units/day). Changes in biochemical response and in body composition were assessed using dual-x-ray energy absormetry, handgrip strength and blood tests before and after supplementation.Results: The majority of the sample were vitamin D deficient. There was no difference in the deficient group for handgrip strength after the supplementation (p=0,489), but PTH had a statistically significant reduction (p=0.001). Besides, the deficient group had a decrease in lean mass even after the intervention (p=0.006). The results were similar when comparing within results of the insufficient group, however lean mass remained stable (p=0.423).Conclusion: Three-month cholecalciferol supplementation alone in elderly women with doses according to 25(OH)D serum was insufficient to change handgrip strength and total lean muscle mass, however secondary hyperparathyroidism was corrected. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/pajar/article/view/32016 10.15448/2357-9641.2019.1.32016 |
url |
https://revistaseletronicas.pucrs.br/ojs/index.php/pajar/article/view/32016 |
identifier_str_mv |
10.15448/2357-9641.2019.1.32016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/pajar/article/view/32016/17941 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 PAJAR - Pan-American Journal of Aging Research info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 PAJAR - Pan-American Journal of Aging Research |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
PAJAR - Pan American Journal of Aging Research; Vol. 7 No. 1 (2019); e32016 PAJAR - Pan-American Journal of Aging Research; Vol. 7 Núm. 1 (2019); e32016 PAJAR - Pan-American Journal of Aging Research; v. 7 n. 1 (2019); e32016 2357-9641 10.15448/2357-9641.2019.1 reponame:PAJAR - Pan American Journal of Aging Research instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUCRS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUCRS |
institution |
PUCRS |
reponame_str |
PAJAR - Pan American Journal of Aging Research |
collection |
PAJAR - Pan American Journal of Aging Research |
repository.name.fl_str_mv |
PAJAR - Pan American Journal of Aging Research - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
cataldo@pucrs.br||pajar@pucrs.br |
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1797174625608663040 |