Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]

Detalhes bibliográficos
Autor(a) principal: Gottlieb, Maria Gabriela
Data de Publicação: 2011
Outros Autores: Morassutti, Alessandra Loureiro, da Cruz, Ivana Mânica
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712
Resumo: Aims: To perform a narrative review on the role of epidemiological transition in the imbalance of oxidative metabolism involved in the etiology of chronic noncommunicable diseases from an evolutionary, environmental and socio-cultural perspective of the Homo sapiens species. Source of data: The sources consulted were Medline, LILACS, and the Brazilian Institute of Geography and Statistics databases. Summary of findings: Several studies have investigated the role of oxidative metabolism in the genesis of chronic non-communicable diseases, suggesting an association between the breakdown of cellular homeostasis and the increased risk for these diseases. Evidence suggests that this breakdown in homeostasis and the emergence of chronic non-communicable diseases has been caused by epidemiological transitions that began in the Neolithic Period, with changes in the ecological relationships between humans, plants, animals and pathogens. These changes led to loss of diversity of food, sedentary lifestyle and pollution, by creating disturbances in cellular redox balance, and increased incidence of chronic non-communicable diseases. Conclusions: Changes along the human evolutionary history affected the cellular metabolism by promoting the onset of chronic non-communicable diseases. Therefore it is essential to understand how these changes occurred and their pathophysiological impact in the body, for identifying individuals who are more susceptible to develop chronic non-communicable diseases, and to build action plans for prevention.
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spelling Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]Transição epidemiológica, estresse oxidativo e doenças crônicas não transmissíveis sob uma perspectiva evolutivaOXIDATIVE STRESSBIOLOGICAL EVOLUTIONCHRONIC DISEASEEPIDEMIOLOGICAL TRANSITIONHEALTH TRANSITIONDEMOGRAPHIC AGINGHUMANS.ESTRESSE OXIDATIVOEVOLUÇÃO BIOLÓGICADOENÇA CRÔNICATRANSIÇÃO EPIDEMIOLÓGICAENVELHECIMENTO DA POPULAÇÃOHUMANOS.Aims: To perform a narrative review on the role of epidemiological transition in the imbalance of oxidative metabolism involved in the etiology of chronic noncommunicable diseases from an evolutionary, environmental and socio-cultural perspective of the Homo sapiens species. Source of data: The sources consulted were Medline, LILACS, and the Brazilian Institute of Geography and Statistics databases. Summary of findings: Several studies have investigated the role of oxidative metabolism in the genesis of chronic non-communicable diseases, suggesting an association between the breakdown of cellular homeostasis and the increased risk for these diseases. Evidence suggests that this breakdown in homeostasis and the emergence of chronic non-communicable diseases has been caused by epidemiological transitions that began in the Neolithic Period, with changes in the ecological relationships between humans, plants, animals and pathogens. These changes led to loss of diversity of food, sedentary lifestyle and pollution, by creating disturbances in cellular redox balance, and increased incidence of chronic non-communicable diseases. Conclusions: Changes along the human evolutionary history affected the cellular metabolism by promoting the onset of chronic non-communicable diseases. Therefore it is essential to understand how these changes occurred and their pathophysiological impact in the body, for identifying individuals who are more susceptible to develop chronic non-communicable diseases, and to build action plans for prevention.Objetivo: realizar uma revisão narrativa sobre o papel das transições epidemiológicas no desequilíbrio do metabolismo oxidativo envolvido na etiologia das doenças crônicas não transmissíveis, sob uma perspectiva evolutiva, ambiental e sociocultural da espécie Homo sapiens. Fonte de dados: as fontes consultadas foram as bases de dados Medline, LILACS e do Instituto Brasileiro de Geografia e Estatística. Síntese dos dados: diversos estudos têm investigado o papel do metabolismo oxidativo na gênese das doenças crônicas não transmissíveis, sugerindo uma associação entre a quebra da homeostasia celular e o aumento do risco para estas doenças. Evidências sugerem que essa quebra na homeostasia e o surgimento das doenças crônicas não transmissíveis tenham sido causados pelas transições epidemiológicas que iniciaram no Período Neolítico, com alterações entre as relações ecológicas entre humanos, plantas, animais e patógenos. Essas alterações levaram à perda de diversidade de alimentos, sedentarismo e poluição, criando distúrbios no equilíbrio redox celular e aumento da incidência das doenças crônicas não transmissíveis. Conclusões: mudanças ao longo da história evolutiva humana afetaram o metabolismo celular promovendo o desencadeamento de doenças crônicas não transmissíveis. Portanto, é fundamental compreendermos como essas mudanças ocorreram e qual o seu impacto fisiopatológico no organismo, para identificarmos indivíduos que são mais suscetíveis a desenvolverem doenças crônicas não transmissíveis, bem como para a construção de planos de ação para a sua prevenção.Editora da PUCRS - ediPUCRS2011-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712Scientia Medica; Vol. 21 No. 2 (2011); 69-80Scientia Medica; v. 21 n. 2 (2011); 69-801980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712/6274https://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712/6275Gottlieb, Maria GabrielaMorassutti, Alessandra Loureiroda Cruz, Ivana Mânicainfo:eu-repo/semantics/openAccess2013-07-16T12:00:21Zoai:ojs.revistaseletronicas.pucrs.br:article/8712Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2013-07-16T12:00:21Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
Transição epidemiológica, estresse oxidativo e doenças crônicas não transmissíveis sob uma perspectiva evolutiva
title Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
spellingShingle Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
Gottlieb, Maria Gabriela
OXIDATIVE STRESS
BIOLOGICAL EVOLUTION
CHRONIC DISEASE
EPIDEMIOLOGICAL TRANSITION
HEALTH TRANSITION
DEMOGRAPHIC AGING
HUMANS.
ESTRESSE OXIDATIVO
EVOLUÇÃO BIOLÓGICA
DOENÇA CRÔNICA
TRANSIÇÃO EPIDEMIOLÓGICA
ENVELHECIMENTO DA POPULAÇÃO
HUMANOS.
title_short Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
title_full Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
title_fullStr Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
title_full_unstemmed Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
title_sort Epidemiological transition, oxidative stress and chronic non-communicable diseases [Abstract in English]
author Gottlieb, Maria Gabriela
author_facet Gottlieb, Maria Gabriela
Morassutti, Alessandra Loureiro
da Cruz, Ivana Mânica
author_role author
author2 Morassutti, Alessandra Loureiro
da Cruz, Ivana Mânica
author2_role author
author
dc.contributor.author.fl_str_mv Gottlieb, Maria Gabriela
Morassutti, Alessandra Loureiro
da Cruz, Ivana Mânica
dc.subject.por.fl_str_mv OXIDATIVE STRESS
BIOLOGICAL EVOLUTION
CHRONIC DISEASE
EPIDEMIOLOGICAL TRANSITION
HEALTH TRANSITION
DEMOGRAPHIC AGING
HUMANS.
ESTRESSE OXIDATIVO
EVOLUÇÃO BIOLÓGICA
DOENÇA CRÔNICA
TRANSIÇÃO EPIDEMIOLÓGICA
ENVELHECIMENTO DA POPULAÇÃO
HUMANOS.
topic OXIDATIVE STRESS
BIOLOGICAL EVOLUTION
CHRONIC DISEASE
EPIDEMIOLOGICAL TRANSITION
HEALTH TRANSITION
DEMOGRAPHIC AGING
HUMANS.
ESTRESSE OXIDATIVO
EVOLUÇÃO BIOLÓGICA
DOENÇA CRÔNICA
TRANSIÇÃO EPIDEMIOLÓGICA
ENVELHECIMENTO DA POPULAÇÃO
HUMANOS.
description Aims: To perform a narrative review on the role of epidemiological transition in the imbalance of oxidative metabolism involved in the etiology of chronic noncommunicable diseases from an evolutionary, environmental and socio-cultural perspective of the Homo sapiens species. Source of data: The sources consulted were Medline, LILACS, and the Brazilian Institute of Geography and Statistics databases. Summary of findings: Several studies have investigated the role of oxidative metabolism in the genesis of chronic non-communicable diseases, suggesting an association between the breakdown of cellular homeostasis and the increased risk for these diseases. Evidence suggests that this breakdown in homeostasis and the emergence of chronic non-communicable diseases has been caused by epidemiological transitions that began in the Neolithic Period, with changes in the ecological relationships between humans, plants, animals and pathogens. These changes led to loss of diversity of food, sedentary lifestyle and pollution, by creating disturbances in cellular redox balance, and increased incidence of chronic non-communicable diseases. Conclusions: Changes along the human evolutionary history affected the cellular metabolism by promoting the onset of chronic non-communicable diseases. Therefore it is essential to understand how these changes occurred and their pathophysiological impact in the body, for identifying individuals who are more susceptible to develop chronic non-communicable diseases, and to build action plans for prevention.
publishDate 2011
dc.date.none.fl_str_mv 2011-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712/6274
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/8712/6275
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 21 No. 2 (2011); 69-80
Scientia Medica; v. 21 n. 2 (2011); 69-80
1980-6108
1806-5562
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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