Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English]
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Scientia Medica (Porto Alegre. Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/scientiamedica/article/view/12084 |
Resumo: | AIMS: To evaluate the role of pigment Lawsonia inermis (henna) as a carrier of antigens in transcutaneous vaccination in mice. METHODS: Mice were immunized transcutaneously into the skin of the abdomen and the ear’s skin with crude antigen of Paracoccidioides brasiliensis and with bovine serum albumin at concentrations of 1, 10 and 50 mg/mL, three times at one week intervals in the presence or absence of pigments L. inermis. One week after last immunization, the animals were evaluated for the presence of serum antibodies, interleucin-4 and interferon-gamma cytokines, and nitric oxide in culture supernatants. RESULTS: No specific antibodies were detected to P.brasiliensis or bovine serum albumin antigens. There were no significant differences in the production of nitric oxide, interleucin-4 and interferon-gamma in supernatants of cell culture. CONCLUSIONS: Transcutaneous immunization with crude antigen of P. brasiliensis or bovine serum albumin suspended in pigment of L. inermis produced no detectable antigenic response in mice. |
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Scientia Medica (Porto Alegre. Online) |
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Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English]Avaliação do pigmento de Lawsonia inermis (henna) como carreador de antígenos inoculados por via transcutânea em camundongosVACCINATIONTRANSCUTANEOUS ADMINISTRATIONANTIBODIESADJUVANTSIMMUNOLOGICIMMUNOADJUVANTSVACINAÇÃOADMINISTRAÇÃO TRANSCUTÂNEAANTICORPOSADJUVANTES IMUNOLÓGICOSIMUNOADJUVANTESAIMS: To evaluate the role of pigment Lawsonia inermis (henna) as a carrier of antigens in transcutaneous vaccination in mice. METHODS: Mice were immunized transcutaneously into the skin of the abdomen and the ear’s skin with crude antigen of Paracoccidioides brasiliensis and with bovine serum albumin at concentrations of 1, 10 and 50 mg/mL, three times at one week intervals in the presence or absence of pigments L. inermis. One week after last immunization, the animals were evaluated for the presence of serum antibodies, interleucin-4 and interferon-gamma cytokines, and nitric oxide in culture supernatants. RESULTS: No specific antibodies were detected to P.brasiliensis or bovine serum albumin antigens. There were no significant differences in the production of nitric oxide, interleucin-4 and interferon-gamma in supernatants of cell culture. CONCLUSIONS: Transcutaneous immunization with crude antigen of P. brasiliensis or bovine serum albumin suspended in pigment of L. inermis produced no detectable antigenic response in mice.OBJETIVOS: Avaliar o papel do pigmento de Lawsonia inermis (henna) como carreador de antígenos em esquema de vacinação transcutânea em camundongos. MÉTODOS: Camundongos foram imunizados por via transcutânea na pele do abdômen e na pele da orelha com antígeno bruto de Paracoccidioides brasiliensis e com albumina sérica bovina nas concentrações de 1, 10 e 50 mg/mL, por três vezes em intervalos de uma semana, na presença ou ausência de pigmentos de L. inermis. Uma semana após a última imunização, foram avaliadas a presença de anticorpos anti-antígenos no soro, das citocinas interleucina-4 e interferon-gama e de óxido nítrico em sobrenadante de cultura. RESULTADOS: Não foram detectados anticorpos específicos anti-antígenos de P.brasiliensis ou albumina sérica bovina no soro. No foram encontradas diferenças significativas na produção de óxido nítrico e nos níveis de interleucina-4 e interferon-gama em sobrenadantes de cultura celular. CONCLUSÕES: As vacinações transcutâneas com antígeno bruto de P. brasiliensis e albumina sérica bovina em suspensão de pigmento de L. inermis não produziram resposta antigênica detectável em camundongos.Editora da PUCRS - ediPUCRS2013-03-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1208410.15448/1980-6108.2013.1.12084Scientia Medica; Vol. 23 No. 1 (2013); 34-40Scientia Medica; v. 23 n. 1 (2013); 34-401980-61081806-556210.15448/1980-6108.2013.1reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/12084/9044https://revistaseletronicas.pucrs.br/scientiamedica/article/view/12084/9045Biffi, Karolinede Rezende, Alexandre Gonçalvesde Almeida, LetíciaYajima, Caroline Kimie BrandãoBarbieri, Fernanda CintoMoreira, Marcela de Limade Britto, Maria Cristina LorenciniRosa, Vanessa Lopesda Silva, Ticiane Batistade Lima, Tayra Ferreira OliveiraCosta, Renata de Oliveira SantosVasconcelos, Pedro Eduardo Nascimento SilvaCoelho, Luiz Felipe LeomilMalaquias, Luiz Cosme Cottainfo:eu-repo/semantics/openAccess2017-08-28T14:50:12Zoai:ojs.revistaseletronicas.pucrs.br:article/12084Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2017-08-28T14:50:12Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] Avaliação do pigmento de Lawsonia inermis (henna) como carreador de antígenos inoculados por via transcutânea em camundongos |
title |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] |
spellingShingle |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] Biffi, Karoline VACCINATION TRANSCUTANEOUS ADMINISTRATION ANTIBODIES ADJUVANTS IMMUNOLOGIC IMMUNOADJUVANTS VACINAÇÃO ADMINISTRAÇÃO TRANSCUTÂNEA ANTICORPOS ADJUVANTES IMUNOLÓGICOS IMUNOADJUVANTES |
title_short |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] |
title_full |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] |
title_fullStr |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] |
title_full_unstemmed |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] |
title_sort |
Evaluation of Lawsonia inermis (henna) pigment as a carrier of antigens inoculated by transcutaneous immunization pigment in mice[Abstract in English] |
author |
Biffi, Karoline |
author_facet |
Biffi, Karoline de Rezende, Alexandre Gonçalves de Almeida, Letícia Yajima, Caroline Kimie Brandão Barbieri, Fernanda Cinto Moreira, Marcela de Lima de Britto, Maria Cristina Lorencini Rosa, Vanessa Lopes da Silva, Ticiane Batista de Lima, Tayra Ferreira Oliveira Costa, Renata de Oliveira Santos Vasconcelos, Pedro Eduardo Nascimento Silva Coelho, Luiz Felipe Leomil Malaquias, Luiz Cosme Cotta |
author_role |
author |
author2 |
de Rezende, Alexandre Gonçalves de Almeida, Letícia Yajima, Caroline Kimie Brandão Barbieri, Fernanda Cinto Moreira, Marcela de Lima de Britto, Maria Cristina Lorencini Rosa, Vanessa Lopes da Silva, Ticiane Batista de Lima, Tayra Ferreira Oliveira Costa, Renata de Oliveira Santos Vasconcelos, Pedro Eduardo Nascimento Silva Coelho, Luiz Felipe Leomil Malaquias, Luiz Cosme Cotta |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Biffi, Karoline de Rezende, Alexandre Gonçalves de Almeida, Letícia Yajima, Caroline Kimie Brandão Barbieri, Fernanda Cinto Moreira, Marcela de Lima de Britto, Maria Cristina Lorencini Rosa, Vanessa Lopes da Silva, Ticiane Batista de Lima, Tayra Ferreira Oliveira Costa, Renata de Oliveira Santos Vasconcelos, Pedro Eduardo Nascimento Silva Coelho, Luiz Felipe Leomil Malaquias, Luiz Cosme Cotta |
dc.subject.por.fl_str_mv |
VACCINATION TRANSCUTANEOUS ADMINISTRATION ANTIBODIES ADJUVANTS IMMUNOLOGIC IMMUNOADJUVANTS VACINAÇÃO ADMINISTRAÇÃO TRANSCUTÂNEA ANTICORPOS ADJUVANTES IMUNOLÓGICOS IMUNOADJUVANTES |
topic |
VACCINATION TRANSCUTANEOUS ADMINISTRATION ANTIBODIES ADJUVANTS IMMUNOLOGIC IMMUNOADJUVANTS VACINAÇÃO ADMINISTRAÇÃO TRANSCUTÂNEA ANTICORPOS ADJUVANTES IMUNOLÓGICOS IMUNOADJUVANTES |
description |
AIMS: To evaluate the role of pigment Lawsonia inermis (henna) as a carrier of antigens in transcutaneous vaccination in mice. METHODS: Mice were immunized transcutaneously into the skin of the abdomen and the ear’s skin with crude antigen of Paracoccidioides brasiliensis and with bovine serum albumin at concentrations of 1, 10 and 50 mg/mL, three times at one week intervals in the presence or absence of pigments L. inermis. One week after last immunization, the animals were evaluated for the presence of serum antibodies, interleucin-4 and interferon-gamma cytokines, and nitric oxide in culture supernatants. RESULTS: No specific antibodies were detected to P.brasiliensis or bovine serum albumin antigens. There were no significant differences in the production of nitric oxide, interleucin-4 and interferon-gamma in supernatants of cell culture. CONCLUSIONS: Transcutaneous immunization with crude antigen of P. brasiliensis or bovine serum albumin suspended in pigment of L. inermis produced no detectable antigenic response in mice. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-03-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/12084 10.15448/1980-6108.2013.1.12084 |
url |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/12084 |
identifier_str_mv |
10.15448/1980-6108.2013.1.12084 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/12084/9044 https://revistaseletronicas.pucrs.br/scientiamedica/article/view/12084/9045 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
Scientia Medica; Vol. 23 No. 1 (2013); 34-40 Scientia Medica; v. 23 n. 1 (2013); 34-40 1980-6108 1806-5562 10.15448/1980-6108.2013.1 reponame:Scientia Medica (Porto Alegre. Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Scientia Medica (Porto Alegre. Online) |
collection |
Scientia Medica (Porto Alegre. Online) |
repository.name.fl_str_mv |
Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
scientiamedica@pucrs.br || editora.periodicos@pucrs.br |
_version_ |
1809101750044459008 |