The therapeutic potential of stem cells for nervous system disease [Abstract in English]
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Scientia Medica (Porto Alegre. Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578 |
Resumo: | Objective: To present scientific evidence of stem cell transplantation in four nervous system diseases: neonatal anoxia, epilepsy, stroke, Parkinson’s disease and peripheral nerve injury. Source of data: Bibliographic review was performed through Medline. Summary of findings: Stem cells transplantation is an important tool in repairing disorders of the central nervous system. Experimental studies have demonstrated regeneration and reconstruction of neuronal circuits through cell therapy. It has been shown that stem cells are able to differentiate into neurons and glia. Experiments involving stem cell transplantation in animals models of neonatal anoxia, stroke, epilepsy, Parkinson’s disease and peripheral nerve injury have also shown functional improvement of treated animals. Conclusion: In spite of scientific evidence favorable to the use of stem cells in neurological disorders, there is still much to be done in order to understand the biological aspects of stem cells, including the signals that determine their proliferation and differentiation, as well as the characteristics of their responses when transplanted to an injured encephalic area. KEY WORDS: STEM CELLS; NERVOUS SYSTEM; STEM CELLS TRANSPLANTATION; CELL DIFFERENTIATION; BRAIN. |
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Scientia Medica (Porto Alegre. Online) |
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The therapeutic potential of stem cells for nervous system disease [Abstract in English]O potencial terapêutico das células-tronco em doenças do sistema nervosoObjective: To present scientific evidence of stem cell transplantation in four nervous system diseases: neonatal anoxia, epilepsy, stroke, Parkinson’s disease and peripheral nerve injury. Source of data: Bibliographic review was performed through Medline. Summary of findings: Stem cells transplantation is an important tool in repairing disorders of the central nervous system. Experimental studies have demonstrated regeneration and reconstruction of neuronal circuits through cell therapy. It has been shown that stem cells are able to differentiate into neurons and glia. Experiments involving stem cell transplantation in animals models of neonatal anoxia, stroke, epilepsy, Parkinson’s disease and peripheral nerve injury have also shown functional improvement of treated animals. Conclusion: In spite of scientific evidence favorable to the use of stem cells in neurological disorders, there is still much to be done in order to understand the biological aspects of stem cells, including the signals that determine their proliferation and differentiation, as well as the characteristics of their responses when transplanted to an injured encephalic area. KEY WORDS: STEM CELLS; NERVOUS SYSTEM; STEM CELLS TRANSPLANTATION; CELL DIFFERENTIATION; BRAIN. Objetivo: Apresentar as evidências científicas do transplante de células-tronco em cinco doenças do sistema nervoso: anóxia neonatal, epilepsia, acidente vascular cerebral, doença de Parkinson e lesão de nervo periférico. Fonte de dados: Revisão bibliográfica utilizando o Medline. Síntese de dados: O transplante de células-tronco é uma importante ferramenta na reparação de distúrbios do sistema nervoso. Estudos experimentais demonstram que a regeneração e a reconstrução do circuito neuronal é possível através da terapia celular. As células-tronco têm demonstrado uma capacidade de se diferenciar em neurônios e glia. Os experimentos utilizando o transplante de células-tronco em modelos animais de anóxia neonatal, isquemia cerebral, epilepsia, doença de Parkinson e lesão de nervo periférico mostraram melhora funcional nos animais tratados. Conclusões: Apesar das evidências científicas favoráveis ao uso de células-tronco em doenças neurológicas, consideráveis avanços necessitam ser feitos para compreender a base biológica das células-tronco, incluindo os sinais que determinam sua proliferação e diferenciação, e a caracterização de suas respostas quando transplantadas em uma área encefálica lesada. UNITERMOS: CÉLULAS-TRONCO; SISTEMA NERVOSO; TRANSPLANTE DE CÉLULAS-TRONCO; DIFERENCIAÇÃO CELULAR; CÉREBRO. Editora da PUCRS - ediPUCRS2006-10-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578Scientia Medica; Vol. 15 No. 4 (2005)Scientia Medica; v. 15 n. 4 (2005)1980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578/1181https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578/7933Paula, Simone dePedroso, Michele F.Dalbem, AndréCosta, Zaquer S. M.Vitola, AffonsoBaes, Cristiane V. W.Silva, Jefferson L. B. daFriedrich, Maurício A. G.Costa, Jaderson C. dainfo:eu-repo/semantics/openAccess2012-06-25T15:56:39Zoai:ojs.revistaseletronicas.pucrs.br:article/1578Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2012-06-25T15:56:39Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] O potencial terapêutico das células-tronco em doenças do sistema nervoso |
title |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] |
spellingShingle |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] Paula, Simone de |
title_short |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] |
title_full |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] |
title_fullStr |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] |
title_full_unstemmed |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] |
title_sort |
The therapeutic potential of stem cells for nervous system disease [Abstract in English] |
author |
Paula, Simone de |
author_facet |
Paula, Simone de Pedroso, Michele F. Dalbem, André Costa, Zaquer S. M. Vitola, Affonso Baes, Cristiane V. W. Silva, Jefferson L. B. da Friedrich, Maurício A. G. Costa, Jaderson C. da |
author_role |
author |
author2 |
Pedroso, Michele F. Dalbem, André Costa, Zaquer S. M. Vitola, Affonso Baes, Cristiane V. W. Silva, Jefferson L. B. da Friedrich, Maurício A. G. Costa, Jaderson C. da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paula, Simone de Pedroso, Michele F. Dalbem, André Costa, Zaquer S. M. Vitola, Affonso Baes, Cristiane V. W. Silva, Jefferson L. B. da Friedrich, Maurício A. G. Costa, Jaderson C. da |
description |
Objective: To present scientific evidence of stem cell transplantation in four nervous system diseases: neonatal anoxia, epilepsy, stroke, Parkinson’s disease and peripheral nerve injury. Source of data: Bibliographic review was performed through Medline. Summary of findings: Stem cells transplantation is an important tool in repairing disorders of the central nervous system. Experimental studies have demonstrated regeneration and reconstruction of neuronal circuits through cell therapy. It has been shown that stem cells are able to differentiate into neurons and glia. Experiments involving stem cell transplantation in animals models of neonatal anoxia, stroke, epilepsy, Parkinson’s disease and peripheral nerve injury have also shown functional improvement of treated animals. Conclusion: In spite of scientific evidence favorable to the use of stem cells in neurological disorders, there is still much to be done in order to understand the biological aspects of stem cells, including the signals that determine their proliferation and differentiation, as well as the characteristics of their responses when transplanted to an injured encephalic area. KEY WORDS: STEM CELLS; NERVOUS SYSTEM; STEM CELLS TRANSPLANTATION; CELL DIFFERENTIATION; BRAIN. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578 |
url |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578/1181 https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1578/7933 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
Scientia Medica; Vol. 15 No. 4 (2005) Scientia Medica; v. 15 n. 4 (2005) 1980-6108 1806-5562 reponame:Scientia Medica (Porto Alegre. Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Scientia Medica (Porto Alegre. Online) |
collection |
Scientia Medica (Porto Alegre. Online) |
repository.name.fl_str_mv |
Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
scientiamedica@pucrs.br || editora.periodicos@pucrs.br |
_version_ |
1809101748410777600 |