Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review

Detalhes bibliográficos
Autor(a) principal: Bittencourt Jacondino, Camila
Data de Publicação: 2014
Outros Autores: Alves Borges, Cristiane, Gottlieb, Maria Gabriela
Tipo de documento: Artigo
Idioma: por
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18173
Resumo: AIMS: Although the etiology of depression is known to be multifactorial, studies have pointed to its association with a mutation in the oxytocin receptor gene (OXTR). The aim of this study was to determine, by means of a systematic review of the literature, whether OXTRs rs53576 and rs2254298 are associated with depression and depressive symptoms or temperament. METHODS: The survey was conducted on the databases Lilacs, PubMed, SciELO, Web of Science, Scopus and Embase, covering the period 2004-2014, in English and Portuguese, with the descriptors receptor da ocitocina/oxytocin receptor gene, added to depressão/depression, temperamento depressivo/depressive temperament, or distúrbios do humor/mood disorder. The following criteria were used for the inclusion of items: original studies with content available in full in English or Portuguese language; only human studies with clinical diagnosis of depression, or screening for symptoms and depressive temperament; studies on the variants rs53576 or rs22524298 of OXTR; and search for association between OXTR polymorphisms and depression and/or depressive symptoms or temperament. RESULTS: Initially 126 articles were captured, but only eight studies met the inclusion criteria. Of the eight articles included, six studies found a significant association between variants OXTR rs53576 and rs225298 with depression, mood and depressive symptoms, while two studies found no association. CONCLUSIONS: The results suggest that OXTR rs53576 and rs2254298 are associated with depressive symptoms and temperament as well as with depression. However, it should be noted that these polymorphisms do not act deterministically; rather, they are influenced or modulated by the environment, which may involve biopsychosocial, affective, ethnic, and gender factors.
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spelling Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic reviewAssociação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemáticaRECEPTORSOXYTOCINOXTRPOLYMORPHISMGENETICDEPRESSION.RECEPTORES DA OCITOCINAOXTRPOLIMORFISMO GENÉTICOOCITOCINADEPRESSÃO.termo 3AIMS: Although the etiology of depression is known to be multifactorial, studies have pointed to its association with a mutation in the oxytocin receptor gene (OXTR). The aim of this study was to determine, by means of a systematic review of the literature, whether OXTRs rs53576 and rs2254298 are associated with depression and depressive symptoms or temperament. METHODS: The survey was conducted on the databases Lilacs, PubMed, SciELO, Web of Science, Scopus and Embase, covering the period 2004-2014, in English and Portuguese, with the descriptors receptor da ocitocina/oxytocin receptor gene, added to depressão/depression, temperamento depressivo/depressive temperament, or distúrbios do humor/mood disorder. The following criteria were used for the inclusion of items: original studies with content available in full in English or Portuguese language; only human studies with clinical diagnosis of depression, or screening for symptoms and depressive temperament; studies on the variants rs53576 or rs22524298 of OXTR; and search for association between OXTR polymorphisms and depression and/or depressive symptoms or temperament. RESULTS: Initially 126 articles were captured, but only eight studies met the inclusion criteria. Of the eight articles included, six studies found a significant association between variants OXTR rs53576 and rs225298 with depression, mood and depressive symptoms, while two studies found no association. CONCLUSIONS: The results suggest that OXTR rs53576 and rs2254298 are associated with depressive symptoms and temperament as well as with depression. However, it should be noted that these polymorphisms do not act deterministically; rather, they are influenced or modulated by the environment, which may involve biopsychosocial, affective, ethnic, and gender factors.OBJETIVOS: Embora a etiologia da depressão seja reconhecidamente multifatorial, estudos têm sugerido que esteja associada a uma mutação no gene receptor da ocitocina (OXTR). O objetivo deste estudo foi verificar, por meio de uma revisão sistemática da literatura, a ocorrência de associação dos OXTR rs53576 e rs2254298 com depressão e sintomas ou temperamento depressivo. MÉTODOS: A pesquisa foi realizada nas bases Lilacs, PubMed, SciELO, Web of Science, Scopus e Embase, abrangendo o período de 2004 a 2014, nos idiomas inglês e português, com o descritor gene receptor da ocitocina/oxytocin receptor gene, adicionado aos descritores depressão/depression, temperamento depressivo/depressive temperament ou distúrbios do humor/mood disorder. Foram utilizados os seguintes critérios para a inclusão dos artigos: estudos originais com conteúdo disponível na íntegra em idioma inglês ou português; somente estudos com seres humanos com diagnóstico clínico de depressão, ou rastreamento de sintomas e temperamento depressivos; estudos com as variantes rs53576 ou rs225298 do gene OXTR; e a investigação de associação entre os polimorfismos OXTR e depressão e/ou sintomas ou temperamento depressivo. RESULTADOS: Foram capturados inicialmente 126 artigos, entretanto apenas oito estudos preencheram os critérios de inclusão. Dos oito artigos incluídos, seis estudos encontraram associação significativa entre as variantes OXTR rs53576 e rs2254298 com depressão, temperamento e sintomas depressivos, enquanto dois estudos não encontraram associação. CONCLUSÕES: Os resultados sugerem que os OXTR rs53576 e rs2254298 estão associados a sintomas, temperamento depressivo e depressão. Contudo, é importante levar em consideração que esses polimorfismos não atuam de forma determinística, ou seja, são influenciados ou modulados por condições ambientais, que podem envolver fatores biopsicossociais, afetivos, étnicos e de gênero.Editora da PUCRS - ediPUCRS2014-12-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1817310.15448/1980-6108.2014.4.18173Scientia Medica; Vol. 24 No. 4 (2014); 411-419Scientia Medica; v. 24 n. 4 (2014); 411-4191980-61081806-556210.15448/1980-6108.2014.4reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/18173/12486Bittencourt Jacondino, CamilaAlves Borges, CristianeGottlieb, Maria Gabrielainfo:eu-repo/semantics/openAccess2015-08-11T18:57:17Zoai:ojs.revistaseletronicas.pucrs.br:article/18173Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2015-08-11T18:57:17Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
Associação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemática
title Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
spellingShingle Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
Bittencourt Jacondino, Camila
RECEPTORS
OXYTOCIN
OXTR
POLYMORPHISM
GENETIC
DEPRESSION.
RECEPTORES DA OCITOCINA
OXTR
POLIMORFISMO GENÉTICO
OCITOCINA
DEPRESSÃO.
termo 3
title_short Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
title_full Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
title_fullStr Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
title_full_unstemmed Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
title_sort Association of oxytocin receptor gene polymorphisms rs53576 and rs2254298 with depression: a systematic review
author Bittencourt Jacondino, Camila
author_facet Bittencourt Jacondino, Camila
Alves Borges, Cristiane
Gottlieb, Maria Gabriela
author_role author
author2 Alves Borges, Cristiane
Gottlieb, Maria Gabriela
author2_role author
author
dc.contributor.author.fl_str_mv Bittencourt Jacondino, Camila
Alves Borges, Cristiane
Gottlieb, Maria Gabriela
dc.subject.por.fl_str_mv RECEPTORS
OXYTOCIN
OXTR
POLYMORPHISM
GENETIC
DEPRESSION.
RECEPTORES DA OCITOCINA
OXTR
POLIMORFISMO GENÉTICO
OCITOCINA
DEPRESSÃO.
termo 3
topic RECEPTORS
OXYTOCIN
OXTR
POLYMORPHISM
GENETIC
DEPRESSION.
RECEPTORES DA OCITOCINA
OXTR
POLIMORFISMO GENÉTICO
OCITOCINA
DEPRESSÃO.
termo 3
description AIMS: Although the etiology of depression is known to be multifactorial, studies have pointed to its association with a mutation in the oxytocin receptor gene (OXTR). The aim of this study was to determine, by means of a systematic review of the literature, whether OXTRs rs53576 and rs2254298 are associated with depression and depressive symptoms or temperament. METHODS: The survey was conducted on the databases Lilacs, PubMed, SciELO, Web of Science, Scopus and Embase, covering the period 2004-2014, in English and Portuguese, with the descriptors receptor da ocitocina/oxytocin receptor gene, added to depressão/depression, temperamento depressivo/depressive temperament, or distúrbios do humor/mood disorder. The following criteria were used for the inclusion of items: original studies with content available in full in English or Portuguese language; only human studies with clinical diagnosis of depression, or screening for symptoms and depressive temperament; studies on the variants rs53576 or rs22524298 of OXTR; and search for association between OXTR polymorphisms and depression and/or depressive symptoms or temperament. RESULTS: Initially 126 articles were captured, but only eight studies met the inclusion criteria. Of the eight articles included, six studies found a significant association between variants OXTR rs53576 and rs225298 with depression, mood and depressive symptoms, while two studies found no association. CONCLUSIONS: The results suggest that OXTR rs53576 and rs2254298 are associated with depressive symptoms and temperament as well as with depression. However, it should be noted that these polymorphisms do not act deterministically; rather, they are influenced or modulated by the environment, which may involve biopsychosocial, affective, ethnic, and gender factors.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18173
10.15448/1980-6108.2014.4.18173
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18173
identifier_str_mv 10.15448/1980-6108.2014.4.18173
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18173/12486
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 24 No. 4 (2014); 411-419
Scientia Medica; v. 24 n. 4 (2014); 411-419
1980-6108
1806-5562
10.15448/1980-6108.2014.4
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reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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