The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]

Detalhes bibliográficos
Autor(a) principal: Cassol, Lina B.
Data de Publicação: 2006
Outros Autores: Garicochea, Bernardo
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581
Resumo: Objectives: Recently, aromatase inhibitors have become an alternative to tamoxifen for hormonal therapy of postmenopausal women with hormone receptor-positive breast cancer. Aromatase inhibitors cause usually few side effects, but there are questions about their long term impact over bone loss and osteoporosis development. This review describes the relationship between estrogens and bone metabolism; pharmacologic and clinical data about main aromatase inhibitors and their impact on osteoporosis development and diagnostic, preventive and therapeutic methods for osteoporosis which must be employed in breast cancer patients receiving aromatase inhibitors. Data search: This review article was based in papers published last five years selected through a Medline search and in selected articles’ references. Data synthesis: The treatment with aromatase inhibitors is related to an increased incidence of osteoporosis and fractures. Conclusion: Diagnostic, preventive and therapeutic methods for osteoporosis must be early employed in breast cancer patients receiving aromatase inhibitors. KEY WORDS: BREAST NEOPLASMS; AROMATASE/ antagonists & inhibitors; OSTEOPOROSIS.
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spelling The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]Uso de inibidores da aromatase no tratamento do câncer de mama e osteoporoseObjectives: Recently, aromatase inhibitors have become an alternative to tamoxifen for hormonal therapy of postmenopausal women with hormone receptor-positive breast cancer. Aromatase inhibitors cause usually few side effects, but there are questions about their long term impact over bone loss and osteoporosis development. This review describes the relationship between estrogens and bone metabolism; pharmacologic and clinical data about main aromatase inhibitors and their impact on osteoporosis development and diagnostic, preventive and therapeutic methods for osteoporosis which must be employed in breast cancer patients receiving aromatase inhibitors. Data search: This review article was based in papers published last five years selected through a Medline search and in selected articles’ references. Data synthesis: The treatment with aromatase inhibitors is related to an increased incidence of osteoporosis and fractures. Conclusion: Diagnostic, preventive and therapeutic methods for osteoporosis must be early employed in breast cancer patients receiving aromatase inhibitors. KEY WORDS: BREAST NEOPLASMS; AROMATASE/ antagonists & inhibitors; OSTEOPOROSIS. Objetivos: Nos últimos anos, os inibidores da aromatase têm emergido como uma alternativa ao tamoxifen no tratamento hormonal de pacientes pósmenopáusicas com câncer de mama, expressando receptores hormonais. Apesar de os inibidores da aromatase possuírem, em geral, um perfil de efeitos colaterais favorável, existem preocupações sobre seu impacto em longo prazo sobre a massa óssea e o desenvolvimento de osteoporose. Essa revisão descreve a relação dos estrógenos com o metabolismo ósseo, o mecanismo de ação e dados clínicos sobre os principais inibidores da aromatase, o impacto dessas drogas no desenvolvimento de osteoporose e as estratégias diagnósticas, preventivas e terapêuticas de osteoporose que devem ser aplicadas em pacientes com câncer de mama recebendo inibidores da aromatase. Fonte dos dados: A presente revisão baseou-se em artigos publicados nos últimos cinco anos, selecionados a partir de uma busca no Medline e de referências da bibliografia selecionada. Síntese dos dados: O tratamento com inibidores da aromatase associa-se a aumento na incidência de osteoporose e fraturas. Conclusão: Estratégias diagnósticas, preventivas e, eventualmente, terapêuticas de osteoporose devem ser empregadas precocemente em pacientes com câncer de mama tratadas com inibidores da aromatase. UNITERMOS: NEOPLASIAS MAMÁRIAS; AROMATASE/ antagonistas & inibidores; OSTEOPOROSE. Editora da PUCRS - ediPUCRS2006-10-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581Scientia Medica; Vol. 15 No. 4 (2005)Scientia Medica; v. 15 n. 4 (2005)1980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581/1184https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581/7936Cassol, Lina B.Garicochea, Bernardoinfo:eu-repo/semantics/openAccess2012-06-25T16:00:12Zoai:ojs.revistaseletronicas.pucrs.br:article/1581Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2012-06-25T16:00:12Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
Uso de inibidores da aromatase no tratamento do câncer de mama e osteoporose
title The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
spellingShingle The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
Cassol, Lina B.
title_short The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
title_full The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
title_fullStr The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
title_full_unstemmed The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
title_sort The use of aromatase inhibitors for breast cancer treatment and osteoporosis [Abstract in English]
author Cassol, Lina B.
author_facet Cassol, Lina B.
Garicochea, Bernardo
author_role author
author2 Garicochea, Bernardo
author2_role author
dc.contributor.author.fl_str_mv Cassol, Lina B.
Garicochea, Bernardo
description Objectives: Recently, aromatase inhibitors have become an alternative to tamoxifen for hormonal therapy of postmenopausal women with hormone receptor-positive breast cancer. Aromatase inhibitors cause usually few side effects, but there are questions about their long term impact over bone loss and osteoporosis development. This review describes the relationship between estrogens and bone metabolism; pharmacologic and clinical data about main aromatase inhibitors and their impact on osteoporosis development and diagnostic, preventive and therapeutic methods for osteoporosis which must be employed in breast cancer patients receiving aromatase inhibitors. Data search: This review article was based in papers published last five years selected through a Medline search and in selected articles’ references. Data synthesis: The treatment with aromatase inhibitors is related to an increased incidence of osteoporosis and fractures. Conclusion: Diagnostic, preventive and therapeutic methods for osteoporosis must be early employed in breast cancer patients receiving aromatase inhibitors. KEY WORDS: BREAST NEOPLASMS; AROMATASE/ antagonists & inhibitors; OSTEOPOROSIS.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581/1184
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1581/7936
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 15 No. 4 (2005)
Scientia Medica; v. 15 n. 4 (2005)
1980-6108
1806-5562
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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