Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]

Detalhes bibliográficos
Autor(a) principal: Coelho, Jaqueline Costa
Data de Publicação: 2007
Outros Autores: Cohen, Mirian, Bender, Ana Lígia, Kupski, Carlos
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621
Resumo: Purpose: Chronic hepatitis C is an insidiously progressive disease, in witch repeated assessment of liver histology is required. Various serum markers have now been introduced. Cartilage oligomeric matrix protein (COMP) is the fifth member of the trombospondin family of extra cellular calcium-binding proteins. It was initially isolated and characterized in cartilage tissue. One study investigated the expression of COMP in normal liver, liver cirrhosis and hepatocellular carcinoma tissues. Our present aim was to asses the serum COMP in patients with chronic hepatitis C. Methods and results: Serum levels of COMP were measured in 10 patients with chronic hepatitis C (cases) and 100 healthy patients (controls). The difference between two groups was not statistical significant and not related to clinical stage of liver fibrosis, virus genotypes, platelets or transaminases alterations. Conclusion: COMP was absent or rarely expressed in liver cirrhosis tissues. Others serum fibrotic markers have now been studied. KEY WORDS: BIOLOGICAL MARKERS; THROMBOSPONDINS; HEPATITIS C, CHRONIC; LIVER CIRRHOSIS.
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spelling Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]Expressão da proteína oligomérica da matriz da cartilagem (COMP/Trombospondina 5) em pacientes portadores de hepatite C crônicaPurpose: Chronic hepatitis C is an insidiously progressive disease, in witch repeated assessment of liver histology is required. Various serum markers have now been introduced. Cartilage oligomeric matrix protein (COMP) is the fifth member of the trombospondin family of extra cellular calcium-binding proteins. It was initially isolated and characterized in cartilage tissue. One study investigated the expression of COMP in normal liver, liver cirrhosis and hepatocellular carcinoma tissues. Our present aim was to asses the serum COMP in patients with chronic hepatitis C. Methods and results: Serum levels of COMP were measured in 10 patients with chronic hepatitis C (cases) and 100 healthy patients (controls). The difference between two groups was not statistical significant and not related to clinical stage of liver fibrosis, virus genotypes, platelets or transaminases alterations. Conclusion: COMP was absent or rarely expressed in liver cirrhosis tissues. Others serum fibrotic markers have now been studied. KEY WORDS: BIOLOGICAL MARKERS; THROMBOSPONDINS; HEPATITIS C, CHRONIC; LIVER CIRRHOSIS.Objetivos: A Hepatite C crônica é uma doença insidiosa e progressiva que necessita de avaliação histológica hepática. Vários marcadores séricos têm sido estudados. A Cartilagem Oligomérica da Matrix Extracelular (COMP) é o quinto elemento da família das trombospondinas, proteínas extracelulares ligadoras de cálcio, sendo inicialmente isolada no tecido cartilaginoso. Um único estudo investigou a expressão da COMP em tecido hepático normal, portador de cirrose e hepatocarcinoma. Nosso estudo visa avaliar os níveis séricos de COMP em pacientes portadores de hepatite C crônica. Métodos e resultados: Níveis séricos de COMP foram dosados em 10 pacientes com Hepatite C crônica (casos) e 100 pacientes saudáveis (controles). A diferença entre a COMP dos dois grupos não foi significativamente estatística e nem relacionada ao estágio clínico de fibrose hepática, genótipo viral, níveis plaquetários ou alterações de transaminases. Conclusão: A COMP não encontra-se alterada em pacientes com hepatopatia crônica pelo HCV. Outros marcadores séricos necessitam ser avaliados. DESCRITORES: MARCADORES BIOLÓGICOS; TROMBOSPONDINAS; HEPATITE C CRÔNICA; COMP, HEPATITE C CRÔNICA; CIRROSE HEPÁTICA. Editora da PUCRS - ediPUCRS2007-03-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621Scientia Medica; Vol. 16 No. 2 (2006)Scientia Medica; v. 16 n. 2 (2006)1980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621/1195https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621/7910Coelho, Jaqueline CostaCohen, MirianBender, Ana LígiaKupski, Carlosinfo:eu-repo/semantics/openAccess2012-06-25T14:52:35Zoai:ojs.revistaseletronicas.pucrs.br:article/1621Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2012-06-25T14:52:35Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
Expressão da proteína oligomérica da matriz da cartilagem (COMP/Trombospondina 5) em pacientes portadores de hepatite C crônica
title Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
spellingShingle Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
Coelho, Jaqueline Costa
title_short Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
title_full Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
title_fullStr Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
title_full_unstemmed Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
title_sort Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]
author Coelho, Jaqueline Costa
author_facet Coelho, Jaqueline Costa
Cohen, Mirian
Bender, Ana Lígia
Kupski, Carlos
author_role author
author2 Cohen, Mirian
Bender, Ana Lígia
Kupski, Carlos
author2_role author
author
author
dc.contributor.author.fl_str_mv Coelho, Jaqueline Costa
Cohen, Mirian
Bender, Ana Lígia
Kupski, Carlos
description Purpose: Chronic hepatitis C is an insidiously progressive disease, in witch repeated assessment of liver histology is required. Various serum markers have now been introduced. Cartilage oligomeric matrix protein (COMP) is the fifth member of the trombospondin family of extra cellular calcium-binding proteins. It was initially isolated and characterized in cartilage tissue. One study investigated the expression of COMP in normal liver, liver cirrhosis and hepatocellular carcinoma tissues. Our present aim was to asses the serum COMP in patients with chronic hepatitis C. Methods and results: Serum levels of COMP were measured in 10 patients with chronic hepatitis C (cases) and 100 healthy patients (controls). The difference between two groups was not statistical significant and not related to clinical stage of liver fibrosis, virus genotypes, platelets or transaminases alterations. Conclusion: COMP was absent or rarely expressed in liver cirrhosis tissues. Others serum fibrotic markers have now been studied. KEY WORDS: BIOLOGICAL MARKERS; THROMBOSPONDINS; HEPATITIS C, CHRONIC; LIVER CIRRHOSIS.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621/1195
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1621/7910
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 16 No. 2 (2006)
Scientia Medica; v. 16 n. 2 (2006)
1980-6108
1806-5562
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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