Pre-clinical trial with external defibrillator
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Scientia Medica (Porto Alegre. Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/scientiamedica/article/view/17538 |
Resumo: | AIMS: To evaluate the efficacy of defibrillation in response to induced ventricular fibrillation and to describe the macroscopic changes in porcine hearts after truncated exponential capacitive discharge shock applied by a prototype defibrillator produced in Brazil and a reference, international market leader defibrillator. METHODS: Sixteen pigs were divided into four groups of four animals each, to verify the effectiveness of the defibrillator in response to induced ventricular fibrillation by applying loads of 50 J to 100 J, and assess the safety of the defibrillator by macroscopic analysis of the skin and heart. Erythema, edema, blistering, fluid in the pericardial cavity, burns, and post-shock charred tissue were evaluated. RESULTS: All pigs, after one minute of inducing ventricular fibrillation, developed tachycardia and progressed to ventricular fibrillation. When used low energy, the prototype equipment obtained 25% of success, with one reversed pig, while the reference equipment has obtained a success rate of 50%, with two reversals. However, with energy 100 J, the prototype equipment reestablished sinus rhythm in three pigs (75%) and the reference product only made effective defibrillation in one (25%). The application of 100 J energy was associated with skin burns Grade II in only one pig with the prototype defibrillator and four pigs with the reference equipment. The heart tissue injuries occurred in equal numbers with both defibrillators. CONCLUSIONS: The prototype defibrillator, when applied with 100 J energy, was more effective in reversing ventricular fibrillation and showed less injury than the reference defibrillator with the same energy. This study may help to raise the technological standard and to increase the supply of qualified health equipment produced in Brazil, replacing and/or decreasing imports and providing a secure next-generation device. |
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Pre-clinical trial with external defibrillatorEnsaio pré-clínico com desfibrilador externoVENTRICULAR FIBRILLATIONEQUIPMENTEXTERNAL DEFIBRILLATORSWINESPRE-CLINICAL RESEARCHFIBRILAÇÃO VENTRICULAREQUIPAMENTODESFIBRILADOR EXTERNOSUÍNOSINVESTIGAÇÃO PRÉ-CLÍNICACardiologiaEngenharia biomédicaAIMS: To evaluate the efficacy of defibrillation in response to induced ventricular fibrillation and to describe the macroscopic changes in porcine hearts after truncated exponential capacitive discharge shock applied by a prototype defibrillator produced in Brazil and a reference, international market leader defibrillator. METHODS: Sixteen pigs were divided into four groups of four animals each, to verify the effectiveness of the defibrillator in response to induced ventricular fibrillation by applying loads of 50 J to 100 J, and assess the safety of the defibrillator by macroscopic analysis of the skin and heart. Erythema, edema, blistering, fluid in the pericardial cavity, burns, and post-shock charred tissue were evaluated. RESULTS: All pigs, after one minute of inducing ventricular fibrillation, developed tachycardia and progressed to ventricular fibrillation. When used low energy, the prototype equipment obtained 25% of success, with one reversed pig, while the reference equipment has obtained a success rate of 50%, with two reversals. However, with energy 100 J, the prototype equipment reestablished sinus rhythm in three pigs (75%) and the reference product only made effective defibrillation in one (25%). The application of 100 J energy was associated with skin burns Grade II in only one pig with the prototype defibrillator and four pigs with the reference equipment. The heart tissue injuries occurred in equal numbers with both defibrillators. CONCLUSIONS: The prototype defibrillator, when applied with 100 J energy, was more effective in reversing ventricular fibrillation and showed less injury than the reference defibrillator with the same energy. This study may help to raise the technological standard and to increase the supply of qualified health equipment produced in Brazil, replacing and/or decreasing imports and providing a secure next-generation device.OBJETIVOS: Avaliar a eficácia da desfibrilação em resposta à fibrilação ventricular induzida e descrever as mudanças macroscópicas ocorridas nos corações de suínos após choque de descarga capacitiva exponencial truncada aplicado por protótipo de desfibrilador produzido no Brasil e por um desfibrilador de referência, líder de mercado internacional. MÉTODOS: Dezesseis suínos foram agrupados em quatro grupos de quatro animais, para verificar a eficácia da desfibrilação em resposta à fibrilação ventricular induzida, aplicando cargas de 50 J e 100 J, assim como avaliar a segurança dos desfibriladores usados, através de análises macroscópicas da pele e do coração. Foram avaliados eritema, edema, bolhas, líquido na cavidade pericárdica, queimaduras e tecido carbonizado pós-choque. RESULTADOS: Todos os suínos, após um minuto da indução à fibrilação ventricular, desenvolveram taquicardia que progrediu à fibrilação ventricular. Quando utilizada baixa energia, o equipamento protótipo obteve 25% de sucesso com um suíno revertido, enquanto o equipamento referência obteve 50% de sucesso, com duas reversões. Entretanto, com energia a 100 J, o equipamento protótipo reestabeleceu o ritmo sinusal em três suínos (75%) e o equipamento referência realizou somente uma desfibrilação eficaz (25%). A aplicação de energia 100 J associou-se com queimadura cutânea de Grau II em apenas um suíno com o desfibrilador protótipo e em quatro suínos com o equipamento referência. As lesões do tecido cardíaco ocorreram em igual número com ambos os desfibriladores. CONCLUSÕES: O desfibrilador protótipo, quando aplicado com energia 100 J, demonstrou maior eficácia na reversão da fibrilação ventricular e apresentou menor injúria que o desfibrilador de referência com a mesma energia. Este estudo ajudará a elevar o padrão tecnológico e a ampliar a oferta qualificada de equipamentos para a saúde produzidos no Brasil, substituindo e/ou diminuindo importações e oferecendo um dispositivo seguro de última geração.Editora da PUCRS - ediPUCRS2014-12-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1753810.15448/1980-6108.2014.4.17538Scientia Medica; Vol. 24 No. 4 (2014); 336-342Scientia Medica; v. 24 n. 4 (2014); 336-3421980-61081806-556210.15448/1980-6108.2014.4reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/17538/12441Vieira, Amanda Assunçãoda Rosa, Michele dos Santos GomesFagundes, Silvia LemosMarckmann, EduardoInácio, FranciscoKrapft, Stela MariaGianotti, GiordanoNunes, Jefferson BragaRussomano, Thaisinfo:eu-repo/semantics/openAccess2015-08-11T18:57:15Zoai:ojs.revistaseletronicas.pucrs.br:article/17538Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2015-08-11T18:57:15Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Pre-clinical trial with external defibrillator Ensaio pré-clínico com desfibrilador externo |
title |
Pre-clinical trial with external defibrillator |
spellingShingle |
Pre-clinical trial with external defibrillator Vieira, Amanda Assunção VENTRICULAR FIBRILLATION EQUIPMENT EXTERNAL DEFIBRILLATOR SWINES PRE-CLINICAL RESEARCH FIBRILAÇÃO VENTRICULAR EQUIPAMENTO DESFIBRILADOR EXTERNO SUÍNOS INVESTIGAÇÃO PRÉ-CLÍNICA Cardiologia Engenharia biomédica |
title_short |
Pre-clinical trial with external defibrillator |
title_full |
Pre-clinical trial with external defibrillator |
title_fullStr |
Pre-clinical trial with external defibrillator |
title_full_unstemmed |
Pre-clinical trial with external defibrillator |
title_sort |
Pre-clinical trial with external defibrillator |
author |
Vieira, Amanda Assunção |
author_facet |
Vieira, Amanda Assunção da Rosa, Michele dos Santos Gomes Fagundes, Silvia Lemos Marckmann, Eduardo Inácio, Francisco Krapft, Stela Maria Gianotti, Giordano Nunes, Jefferson Braga Russomano, Thais |
author_role |
author |
author2 |
da Rosa, Michele dos Santos Gomes Fagundes, Silvia Lemos Marckmann, Eduardo Inácio, Francisco Krapft, Stela Maria Gianotti, Giordano Nunes, Jefferson Braga Russomano, Thais |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vieira, Amanda Assunção da Rosa, Michele dos Santos Gomes Fagundes, Silvia Lemos Marckmann, Eduardo Inácio, Francisco Krapft, Stela Maria Gianotti, Giordano Nunes, Jefferson Braga Russomano, Thais |
dc.subject.por.fl_str_mv |
VENTRICULAR FIBRILLATION EQUIPMENT EXTERNAL DEFIBRILLATOR SWINES PRE-CLINICAL RESEARCH FIBRILAÇÃO VENTRICULAR EQUIPAMENTO DESFIBRILADOR EXTERNO SUÍNOS INVESTIGAÇÃO PRÉ-CLÍNICA Cardiologia Engenharia biomédica |
topic |
VENTRICULAR FIBRILLATION EQUIPMENT EXTERNAL DEFIBRILLATOR SWINES PRE-CLINICAL RESEARCH FIBRILAÇÃO VENTRICULAR EQUIPAMENTO DESFIBRILADOR EXTERNO SUÍNOS INVESTIGAÇÃO PRÉ-CLÍNICA Cardiologia Engenharia biomédica |
description |
AIMS: To evaluate the efficacy of defibrillation in response to induced ventricular fibrillation and to describe the macroscopic changes in porcine hearts after truncated exponential capacitive discharge shock applied by a prototype defibrillator produced in Brazil and a reference, international market leader defibrillator. METHODS: Sixteen pigs were divided into four groups of four animals each, to verify the effectiveness of the defibrillator in response to induced ventricular fibrillation by applying loads of 50 J to 100 J, and assess the safety of the defibrillator by macroscopic analysis of the skin and heart. Erythema, edema, blistering, fluid in the pericardial cavity, burns, and post-shock charred tissue were evaluated. RESULTS: All pigs, after one minute of inducing ventricular fibrillation, developed tachycardia and progressed to ventricular fibrillation. When used low energy, the prototype equipment obtained 25% of success, with one reversed pig, while the reference equipment has obtained a success rate of 50%, with two reversals. However, with energy 100 J, the prototype equipment reestablished sinus rhythm in three pigs (75%) and the reference product only made effective defibrillation in one (25%). The application of 100 J energy was associated with skin burns Grade II in only one pig with the prototype defibrillator and four pigs with the reference equipment. The heart tissue injuries occurred in equal numbers with both defibrillators. CONCLUSIONS: The prototype defibrillator, when applied with 100 J energy, was more effective in reversing ventricular fibrillation and showed less injury than the reference defibrillator with the same energy. This study may help to raise the technological standard and to increase the supply of qualified health equipment produced in Brazil, replacing and/or decreasing imports and providing a secure next-generation device. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/17538 10.15448/1980-6108.2014.4.17538 |
url |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/17538 |
identifier_str_mv |
10.15448/1980-6108.2014.4.17538 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/17538/12441 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
Scientia Medica; Vol. 24 No. 4 (2014); 336-342 Scientia Medica; v. 24 n. 4 (2014); 336-342 1980-6108 1806-5562 10.15448/1980-6108.2014.4 reponame:Scientia Medica (Porto Alegre. Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Scientia Medica (Porto Alegre. Online) |
collection |
Scientia Medica (Porto Alegre. Online) |
repository.name.fl_str_mv |
Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
scientiamedica@pucrs.br || editora.periodicos@pucrs.br |
_version_ |
1809101750575038464 |