Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Scientia Medica (Porto Alegre. Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/scientiamedica/article/view/5983 |
Resumo: | AIMS: To determine the prevalence of congenital toxoplasmosis in Brazil from samples of dried blood on filter paper from neonates attended by a private program of neonatal screening. METHODS: Blood samples collected from neonates by puncturing the heel and dried on filter paper, received from all Brazilian states from September 1995 to July 2009, were tested for Toxoplasma gondii-specific IgM antibodies. For each positive screening test, confirmatory tests were performed in sera of mothers and newborns, obtained by venipuncture. The infants were monitored and classified as infected according to one of the following criteria: presence of Toxoplasma gondii specific IgM and IgG in the newborn and the mother; Toxoplasma gondii-specific IgM and IgG in the newborn only; Toxoplasma gondii-specific IgM and IgG in the mother only; or increasing amount of Toxoplasma gondii-specific IgG in the infant. RESULTS: A total of 800,164 blood samples were tested. The overall prevalence of congenital toxoplasmosis was found to be 1/1,613 (6/10,000) in the country, ranging from 1/5,447 to 1/495 (2/10,000 to 20/10,000) in different states. CONCLUSIONS: Neonatal screening on a large scale is an important tool for determining the prevalence of congenital toxoplasmosis. The high prevalence of the infection in Brazil and the wide variability of its epidemiology among the states support the need to develop policies on health and education to prevent and control congenital toxoplasmosis across the country, respecting the peculiarities of each state. |
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Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screeningEstimativa da distribuição regional da toxoplasmose congênita no Brasil a partir dos resultados de triagem neonatalTOXOPLASMOSISCONGENITAL/prevention & controlAIMS: To determine the prevalence of congenital toxoplasmosis in Brazil from samples of dried blood on filter paper from neonates attended by a private program of neonatal screening. METHODS: Blood samples collected from neonates by puncturing the heel and dried on filter paper, received from all Brazilian states from September 1995 to July 2009, were tested for Toxoplasma gondii-specific IgM antibodies. For each positive screening test, confirmatory tests were performed in sera of mothers and newborns, obtained by venipuncture. The infants were monitored and classified as infected according to one of the following criteria: presence of Toxoplasma gondii specific IgM and IgG in the newborn and the mother; Toxoplasma gondii-specific IgM and IgG in the newborn only; Toxoplasma gondii-specific IgM and IgG in the mother only; or increasing amount of Toxoplasma gondii-specific IgG in the infant. RESULTS: A total of 800,164 blood samples were tested. The overall prevalence of congenital toxoplasmosis was found to be 1/1,613 (6/10,000) in the country, ranging from 1/5,447 to 1/495 (2/10,000 to 20/10,000) in different states. CONCLUSIONS: Neonatal screening on a large scale is an important tool for determining the prevalence of congenital toxoplasmosis. The high prevalence of the infection in Brazil and the wide variability of its epidemiology among the states support the need to develop policies on health and education to prevent and control congenital toxoplasmosis across the country, respecting the peculiarities of each state.OBJETIVO: estimar a prevalência da toxoplasmose congênita Brasil por meio de amostras de sangue seco em papel filtro, obtidas de neonatos atendidos por um programa privado de triagem neonatal. MÉTODOS: amostras de sangue coletadas de neonatos por punção de calcâneo e absorvidas em papel filtro, recebidas de todos os estados brasileiros entre setembro de 1995 e julho de 2009, foram testadas para anticorpos IgM anti-Toxoplasma gondii. Para cada teste positivo na triagem, foram realizados exames confirmatórios em soros das mães e dos neonatos, obtidos por punção venosa periférica. Os casos foram considerados confirmados de acordo com um dos seguintes critérios: presença de IgM e IgG anti-Toxoplasma gondii no neonato e na mãe; IgM e IgG anti-Toxoplasma gondii somente no neonato; IgM e IgG anti-Toxoplasma gondii somente na mãe; ou aumento progressivo dos anticorpos IgG anti-Toxoplasma gondii no lactente. RESULTADOS: foram testadas 800.164 amostras. Observou-se uma prevalência geral de toxoplasmose congênita no país de 1/1.613, variando de 1/1.547 a 1/495 (2/10.000 to 20/10.000) em diferentes estados. CONCLUSÕES: a triagem neonatal em larga escala é uma ferramenta importante para a determinação da prevalência da toxoplasmose congênita. A alta prevalência dessa infecção no Brasil e a ampla variabilidade de sua epidemiologia entre os estados confirmam a necessidade de políticas de saúde e educação voltadas à prevenção e ao controle da toxoplasmose congênita em todo o país, respeitando as peculiaridades de cada estado.Editora da PUCRS - ediPUCRS2010-04-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/5983Scientia Medica; Vol. 20 No. 1 (2010): Special issue on Toxoplasmosis; 64-70Scientia Medica; v. 20 n. 1 (2010): Número especial sobre Toxoplasmose; 64-701980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/5983/4877Neto, Eurico CamargoAmorim, FabianaLago, Eleonor Gastalinfo:eu-repo/semantics/openAccess2018-01-26T21:17:57Zoai:ojs.revistaseletronicas.pucrs.br:article/5983Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2018-01-26T21:17:57Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening Estimativa da distribuição regional da toxoplasmose congênita no Brasil a partir dos resultados de triagem neonatal |
title |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening |
spellingShingle |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening Neto, Eurico Camargo TOXOPLASMOSIS CONGENITAL/prevention & control |
title_short |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening |
title_full |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening |
title_fullStr |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening |
title_full_unstemmed |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening |
title_sort |
Estimation of the regional distribution of congenital toxoplasmosis in Brazil from the results of neonatal screening |
author |
Neto, Eurico Camargo |
author_facet |
Neto, Eurico Camargo Amorim, Fabiana Lago, Eleonor Gastal |
author_role |
author |
author2 |
Amorim, Fabiana Lago, Eleonor Gastal |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Neto, Eurico Camargo Amorim, Fabiana Lago, Eleonor Gastal |
dc.subject.por.fl_str_mv |
TOXOPLASMOSIS CONGENITAL/prevention & control |
topic |
TOXOPLASMOSIS CONGENITAL/prevention & control |
description |
AIMS: To determine the prevalence of congenital toxoplasmosis in Brazil from samples of dried blood on filter paper from neonates attended by a private program of neonatal screening. METHODS: Blood samples collected from neonates by puncturing the heel and dried on filter paper, received from all Brazilian states from September 1995 to July 2009, were tested for Toxoplasma gondii-specific IgM antibodies. For each positive screening test, confirmatory tests were performed in sera of mothers and newborns, obtained by venipuncture. The infants were monitored and classified as infected according to one of the following criteria: presence of Toxoplasma gondii specific IgM and IgG in the newborn and the mother; Toxoplasma gondii-specific IgM and IgG in the newborn only; Toxoplasma gondii-specific IgM and IgG in the mother only; or increasing amount of Toxoplasma gondii-specific IgG in the infant. RESULTS: A total of 800,164 blood samples were tested. The overall prevalence of congenital toxoplasmosis was found to be 1/1,613 (6/10,000) in the country, ranging from 1/5,447 to 1/495 (2/10,000 to 20/10,000) in different states. CONCLUSIONS: Neonatal screening on a large scale is an important tool for determining the prevalence of congenital toxoplasmosis. The high prevalence of the infection in Brazil and the wide variability of its epidemiology among the states support the need to develop policies on health and education to prevent and control congenital toxoplasmosis across the country, respecting the peculiarities of each state. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-04-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/5983 |
url |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/5983 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/5983/4877 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
Scientia Medica; Vol. 20 No. 1 (2010): Special issue on Toxoplasmosis; 64-70 Scientia Medica; v. 20 n. 1 (2010): Número especial sobre Toxoplasmose; 64-70 1980-6108 1806-5562 reponame:Scientia Medica (Porto Alegre. Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Scientia Medica (Porto Alegre. Online) |
collection |
Scientia Medica (Porto Alegre. Online) |
repository.name.fl_str_mv |
Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
scientiamedica@pucrs.br || editora.periodicos@pucrs.br |
_version_ |
1809101749404827648 |