Evaluation of lipid profile in patients with inflammatory bowel disease

Detalhes bibliográficos
Autor(a) principal: Adorne, Elaine de Fatima
Data de Publicação: 2016
Outros Autores: Bodanese, Luiz Carlos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/22964
Resumo: Aims: To evaluate the lipid profile and inflammatory parameters in patients with bowel disease, Crohn’s disease (CD), and ulcerative colitis (UC) and correlate them with disease activity levels.Methods: Cross-sectional study of patients followed up at the Inflammatory Bowel Disease Outpatient Clinic of São Lucas Hospital at Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. The demographic, anthropometric, and metabolic characteristics of patients with chronic inflammatory disease were evaluated. Lipids and inflammatory parameters were evaluated as well as the correlation between the severity of inflammatory disease and metabolic parameters using the Harvey-Bradshaw index for CD and Truelove and Witts’ method for UC.Results: The study included 122 male and female patients with inflammatory bowel disease classified into CD (n=64) and UC (n=58). Women accounted for 54.1% of the sample, with a mean age of 41.6±12.6 years and a BMI of 25±4.4kg/m2. Low-density lipoprotein cholesterol (LDL-c) was significantly higher in UC than in CD (p=0.006). Higher C-reactive protein levels were associated with a more severe inflammatory process in CD patients (p=0.027) according to the Harvey-Bradshaw index. In UC, there was a weak correlation between disease activity and high-density lipoprotein cholesterol (HDL-c) (rs= -0.29; p=0.036) and between disease activity and total cholesterol (rs= -0.30; p=0.028) according to Truelove and Witts’ index. The HDL-c of about two thirds of the patients (67.6%) was below the recommended values.Conclusions: LDL-c was significantly higher in patients with UC than in those with CD. HDL-c was lower in patients with more severe inflammatory disease triggered by UC. Increased C-reactive protein levels in CD patients were associated with severity of the inflammatory process determined by the Harvey-Bradshaw index. The detection of these metabolic changes may help identify individuals with potential risk for cardiovascular events.
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spelling Evaluation of lipid profile in patients with inflammatory bowel diseaseAvaliação do perfil lipídico em pacientes com doença inflamatória intestinaldoença de Crohnretocolite ulcerativadislipidemias.Aims: To evaluate the lipid profile and inflammatory parameters in patients with bowel disease, Crohn’s disease (CD), and ulcerative colitis (UC) and correlate them with disease activity levels.Methods: Cross-sectional study of patients followed up at the Inflammatory Bowel Disease Outpatient Clinic of São Lucas Hospital at Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. The demographic, anthropometric, and metabolic characteristics of patients with chronic inflammatory disease were evaluated. Lipids and inflammatory parameters were evaluated as well as the correlation between the severity of inflammatory disease and metabolic parameters using the Harvey-Bradshaw index for CD and Truelove and Witts’ method for UC.Results: The study included 122 male and female patients with inflammatory bowel disease classified into CD (n=64) and UC (n=58). Women accounted for 54.1% of the sample, with a mean age of 41.6±12.6 years and a BMI of 25±4.4kg/m2. Low-density lipoprotein cholesterol (LDL-c) was significantly higher in UC than in CD (p=0.006). Higher C-reactive protein levels were associated with a more severe inflammatory process in CD patients (p=0.027) according to the Harvey-Bradshaw index. In UC, there was a weak correlation between disease activity and high-density lipoprotein cholesterol (HDL-c) (rs= -0.29; p=0.036) and between disease activity and total cholesterol (rs= -0.30; p=0.028) according to Truelove and Witts’ index. The HDL-c of about two thirds of the patients (67.6%) was below the recommended values.Conclusions: LDL-c was significantly higher in patients with UC than in those with CD. HDL-c was lower in patients with more severe inflammatory disease triggered by UC. Increased C-reactive protein levels in CD patients were associated with severity of the inflammatory process determined by the Harvey-Bradshaw index. The detection of these metabolic changes may help identify individuals with potential risk for cardiovascular events.Objetivos: Avaliar o perfil lipídico e parâmetros inflamatórios de pacientes com doença intestinal, doença de Crohn e retocolite ulcerativa, e correlacionar com os níveis de atividade das doenças.Métodos: Estudo transversal com pacientes acompanhados no Ambulatório de Doença Inflamatória Intestinal do Hospital São Lucas da PUCRS. Foram avaliadas as características demográficas, antropométricas e metabólicas dos pacientes com doença intestinal inflamatória crônica. Avaliaram-se parâmetros lipídios e inflamatórios e analisou-se a correlação entre a gravidade da doença inflamatória e os parâmetros metabólicos, na doença de Crohn pelo índice de Harvey-Bradshaw e na retocolite ulcerativa pelo método de Truelove e Witts.Resultados: Participaram do estudo 122 pacientes de ambos os sexos com doença inflamatória intestinal, estratificados em: doença de Crohn (n=64) e retocolite ulcerativa (n=58). As mulheres representaram 54,1% da amostra, a média de idade foi de 41,6±12,6 anos e a média de índice de massa corporal foi de 25 ± 4,4kg/m2.  O colesterol ligado à lipoproteína de baixa densidade (LDL-c) mostrou-se significativamente mais elevado nos pacientes com retocolite ulcerativa comparando-se aos pacientes com doença de Crohn (p=0,006). A proteína C reativa aumentada esteve associada com maior gravidade do processo inflamatório em pacientes com doença de Crohn (p=0,027), quando analisada pelo índice de Harvey-Bradshaw. Na retocolite ulcerativa, conforme o índice de Truelove e Witts, houve correlação fraca entre atividade da doença e colesterol ligado à lipoproteína de alta densidade (HDL-c) (rs= -0,29; p=0,036) e entre atividade da doença e colesterol total (rs= -0,30; p=0,028). Cerca de dois terços dos pacientes (67,6%) apresentaram o HDL-c abaixo dos valores recomendados.Conclusões: O LDL-c mostrou-se significativamente mais elevado nos pacientes com retocolite ulcerativa comparados aos pacientes com doença de Crohn. O HDL-c apresentou níveis reduzidos em pacientes com doença inflamatória mais grave por retocolite ulcerativa. A proteína C reativa aumentada em pacientes com doença de Crohn esteve associada com a gravidade do processo inflamatório determinada pelo índice de Harvey-Bradshaw. A detecção dessas alterações metabólicas pode auxiliar na identificação de indivíduos com potencial risco para eventos cardiovasculares.Editora da PUCRS - ediPUCRS2016-06-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/2296410.15448/1980-6108.2016.2.22964Scientia Medica; Vol. 26 No. 2 (2016); ID22964Scientia Medica; v. 26 n. 2 (2016); ID229641980-61081806-556210.15448/1980-6108.2016.2reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/22964/14498Copyright (c) 2016 Scientia Medicainfo:eu-repo/semantics/openAccessAdorne, Elaine de FatimaBodanese, Luiz Carlos2016-09-03T00:28:44Zoai:ojs.revistaseletronicas.pucrs.br:article/22964Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2016-09-03T00:28:44Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Evaluation of lipid profile in patients with inflammatory bowel disease
Avaliação do perfil lipídico em pacientes com doença inflamatória intestinal
title Evaluation of lipid profile in patients with inflammatory bowel disease
spellingShingle Evaluation of lipid profile in patients with inflammatory bowel disease
Adorne, Elaine de Fatima
doença de Crohn
retocolite ulcerativa
dislipidemias.
title_short Evaluation of lipid profile in patients with inflammatory bowel disease
title_full Evaluation of lipid profile in patients with inflammatory bowel disease
title_fullStr Evaluation of lipid profile in patients with inflammatory bowel disease
title_full_unstemmed Evaluation of lipid profile in patients with inflammatory bowel disease
title_sort Evaluation of lipid profile in patients with inflammatory bowel disease
author Adorne, Elaine de Fatima
author_facet Adorne, Elaine de Fatima
Bodanese, Luiz Carlos
author_role author
author2 Bodanese, Luiz Carlos
author2_role author
dc.contributor.author.fl_str_mv Adorne, Elaine de Fatima
Bodanese, Luiz Carlos
dc.subject.por.fl_str_mv doença de Crohn
retocolite ulcerativa
dislipidemias.
topic doença de Crohn
retocolite ulcerativa
dislipidemias.
description Aims: To evaluate the lipid profile and inflammatory parameters in patients with bowel disease, Crohn’s disease (CD), and ulcerative colitis (UC) and correlate them with disease activity levels.Methods: Cross-sectional study of patients followed up at the Inflammatory Bowel Disease Outpatient Clinic of São Lucas Hospital at Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. The demographic, anthropometric, and metabolic characteristics of patients with chronic inflammatory disease were evaluated. Lipids and inflammatory parameters were evaluated as well as the correlation between the severity of inflammatory disease and metabolic parameters using the Harvey-Bradshaw index for CD and Truelove and Witts’ method for UC.Results: The study included 122 male and female patients with inflammatory bowel disease classified into CD (n=64) and UC (n=58). Women accounted for 54.1% of the sample, with a mean age of 41.6±12.6 years and a BMI of 25±4.4kg/m2. Low-density lipoprotein cholesterol (LDL-c) was significantly higher in UC than in CD (p=0.006). Higher C-reactive protein levels were associated with a more severe inflammatory process in CD patients (p=0.027) according to the Harvey-Bradshaw index. In UC, there was a weak correlation between disease activity and high-density lipoprotein cholesterol (HDL-c) (rs= -0.29; p=0.036) and between disease activity and total cholesterol (rs= -0.30; p=0.028) according to Truelove and Witts’ index. The HDL-c of about two thirds of the patients (67.6%) was below the recommended values.Conclusions: LDL-c was significantly higher in patients with UC than in those with CD. HDL-c was lower in patients with more severe inflammatory disease triggered by UC. Increased C-reactive protein levels in CD patients were associated with severity of the inflammatory process determined by the Harvey-Bradshaw index. The detection of these metabolic changes may help identify individuals with potential risk for cardiovascular events.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/22964
10.15448/1980-6108.2016.2.22964
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/22964
identifier_str_mv 10.15448/1980-6108.2016.2.22964
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/22964/14498
dc.rights.driver.fl_str_mv Copyright (c) 2016 Scientia Medica
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2016 Scientia Medica
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 26 No. 2 (2016); ID22964
Scientia Medica; v. 26 n. 2 (2016); ID22964
1980-6108
1806-5562
10.15448/1980-6108.2016.2
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
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instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
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institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
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repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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